The Influence of Airway Resistance in the Dynamic Elastance Model

Laufer, Bernhard; Kretschmer, Jörn; Docherty, Paul; Chiew, Yeong Shiong; Möller, Knut

doi:10.1007/978-3-319-32703-7_12

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…In addition, this investigation confirmed that the airway resistance varies with the airway pressure [23]. The resistance is higher in lower pressure ranges, while in higher airway pressures, the resistance is smaller.…”

Section: Discussionsupporting

confidence: 77%

What Does a First Order Model Tell Us about PEEP Wave Maneuvers?

Laufer¹,

Kretschmer²,

Docherty³

et al. 2017

JBiSE

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Patients with acute respiratory distress syndrome (ARDS) are currently treated with a lung protective ventilation strategy and the application of positive end-expiratory pressure (PEEP), sometimes in combination with recruitment maneuvers. In this study, the respiratory system elastance and airway resistance of each breath before, during and after a specific recruitment maneuver (PEEP wave maneuver) were analyzed in two patient groups, ARDS and control group. A reduction of elastance after the maneuver was observed in ARDS patients. In addition, only healthy lungs exhibited a reduction of the elastance during the course of the maneuver, while the lungs of ARDS patients didn't show that reduction of elastance. The capability of PEEP wave maneuvers to improve lung ventilation was shown and the dynamic behavior of the elastance after the maneuver was illustrated. Healthy lungs adapt faster to changes in mechanical ventilation than the lungs of ARDS patients.

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Section: Discussionsupporting

confidence: 77%

What Does a First Order Model Tell Us about PEEP Wave Maneuvers?

Laufer¹,

Kretschmer²,

Docherty³

et al. 2017

JBiSE

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show abstract

“…1 The outcome of the dynamic Elastance model applied on the data of a mechanical ventilated patient (McREM72). The coloured curves are the E(P) curves of different breaths at 11 different PEEP levels (5 breaths per PEEP level) [15] ventilation data is the easiest way during mechanical ventilation. In addition, this method is advantageous because the patients are not affected by any additional invasive measurement.…”

Section: Introductionmentioning

confidence: 99%

Lung mechanics - airway resistance in the dynamic elastance model

et al. 2016

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The selection of optimal positive end-expiratory pressure (PEEP) levels during mechanical ventilation therapy of patients with acute respiratory distress syndrome (ARDS) remains a problem for clinicians. A particular mooted strategy states that minimizing the energy transferred to the lung during mechanical ventilation could potentially be used to determine the optimal, patient-specific PEEP levels. Furthermore, the dynamic elastance model of pulmonary mechanics could possibly be applied to minimize the energy by localization of the patients' minimum dynamic elastance range. The sensitivity of the dynamic elastance model to variance in the airway resistance was analyzed. Additionally, the airway resistance was determined by using three other established identification methods and was compared to the constant resistance obtained by the dynamic elastance model. For increasing PEEP, the alternative identification methods showed similar decreasing trends of the resistance during inspiration. This declining trend is apparently an exponential decrease. Results showed that the constant airway resistance, presumed by the dynamic elastance model, has to be rechecked and investigated.

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The Influence of Airway Resistance in the Dynamic Elastance Model

Cited by 2 publications

References 18 publications

What Does a First Order Model Tell Us about PEEP Wave Maneuvers?

What Does a First Order Model Tell Us about PEEP Wave Maneuvers?

Lung mechanics - airway resistance in the dynamic elastance model

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