The Influence of Aging on Plasma Sex Hormones in Men: The Telecom Study

Simon, Dominique; Preziosi, Paul; Barrett‐Connor, Elizabeth; Roger, M; Saint-Paul, M; Nahoul, K; Papoz, L

doi:10.1093/oxfordjournals.aje.a116365

Cited by 158 publications

(86 citation statements)

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“…They concluded that diabetes, instead of the medication itself, is the reason for the diabetes-cancer association. The finding of a negative association between prostate cancer and diabetes duration supports the hypothesis of a hormonal mechanism in the protection for prostate cancer in diabetic patients [34,49].…”

Section: Treatment Of Type 2 Diabetes and Cancersupporting

confidence: 72%

Diabetes mellitus, hyperglycaemia and cancer

Simon

Balkau

2010

Diabetes & Metabolism

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Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse. SummaryA moderate increase of cancer risk has been shown in diabetic patients and in subjects with abnormal glucose tolerance, mainly in digestive sites, independently of obesity, with on the contrary a protective effect for prostate cancer. Insulin-resistance with compensatory hyperinsulinemia, and elevated levels of circulating growth factors are usually considered as the link between cancer and hyperglycaemia, through activated cell proliferation. Antidiabetic treatments inducing elevated plasma insulin seem to increase cancer risk and, on the opposite, insulin-sensitizers antidiabetic drugs (metformine, thiazolidinediones) seem to reduce cancer risk. In 2009, a big fuss has been raised concerning a specific action of glargine insulin to increase cancer risk from an observational study in Germany accumulating methodological pitfalls, without any clear confirmation from other studies.Unexplained poor glycaemic control in known diabetic patients should lead to screen for a cancer, and diagnosis of cancer should not distract from appropriate management of diabetes care.Greater public awareness about healthy lifestyles (diet, physical activity) is needed to prevent these two major increasing Public Health issues, and in the meanwhile should reduce the frequency of obesity and cardiovascular diseases in the whole population.Keywords : type 2 diabetes, cancer, hyperinsulinemia, growth factors, epidemiology -3 - RésuméSauf pour la prostate, il existe un risque modérément accru de cancer, en particulier digestif,

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Section: Treatment Of Type 2 Diabetes and Cancersupporting

confidence: 72%

Diabetes mellitus, hyperglycaemia and cancer

Simon

Balkau

2010

Diabetes & Metabolism

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“…Increased age is one of the strongest predictors for coronary artery disease. The Telecom Study demonstrated a significant decrease in testosterone concentration with each decade of life [26]. Both mean intima-media thickness and plaque score, determined by carotid ultrasonography, have been proven to be inversely associated with serum free testosterone concentration in our previous study [27].…”

Section: Discussionmentioning

confidence: 55%

Low Serum Testosterone Concentration in Middle-aged Men with Type 2 Diabetes

et al. 2007

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Abstract. Low concentrations of endogenous androgens have been linked with insulin resistance and atherosclerosis. Men with diabetes have been reported to have lower serum testosterone concentration than non-diabetic men; however, there has never been a large study. The aim of this study was to investigate if endogenous androgen concentration is certainly lower in a relatively large number of Japanese patients with type 2 diabetes compared with healthy men, and to identify what factors may be associated with low serum testosterone concentrations in men with type 2 diabetes. Serum free testosterone concentrations were measured in 524 healthy men and in 331 consecutive Japanese men with type 2 diabetes between 40 and 69 years old. In addition, we investigated the relationships between serum free testosterone concentration and luteinizing hormone (LH) concentration as well as major cardiovascular risk factors including age, blood pressure, plasma lipid concentration, glycemic control (HbA 1c ), and BMI. Serum free testosterone concentrations were lower in men with type 2 diabetes than in healthy men in the 40-49 years group (10.9 ± 3.3 vs. 14.0 ± 3.6 pg/ml, P<0.0001), in the 50-59 years group (10.4 ± 3.2 vs. 12.1 ± 2.9 pg/ml, P<0.0001), and in the 60-69 years group (9.5 ± 2.6 vs. 10.5 ± 2.9 pg/ml, P = 0.0104). A negative correlation was found between serum free testosterone and LH concentrations (r = -0.326, P<0.0001). In conclusion, serum free testosterone concentration is certainly lower in a relatively large number of Japanese patients with type 2 diabetes compared with healthy men with each decade of life between 40 and 69 years old.

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“…A large number of studies demonstrated general decline in serum levels of testosterone among men over 50 years of age [Gray et al 1991;Simon et al 1992;Belanger et al 1994;Ferrini and Barrett-Connor 1998]. Previous reports from animal studies indicate that the epididymis undergoes morphological changes with aging, that probably affects sperm maturation.…”

Section: Discussionmentioning

confidence: 99%

Association between Age and Epididymal and Accessory Sex Gland Function and their Relation to Sperm Motility

Elzanaty

2007

Archives of Andrology

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Increased male age has been associated with significant reduction in pregnancy rates. This study investigated the association between age, the function of epididymal and accessory sex glands, and their relation to sperm motility. Ejaculates from 498 men assessed for infertility were analysed according to WHO [1999] guidelines. Seminal markers of epididymal (neutral a-glucosidase (NAG)), prostatic (prostate-specific antigen (PSA) and zinc), and seminal vesicle function (fructose) were measured. Four groups according to age were defined: G 21-30 (21-30 years), G 31-40 (31-40 years), G 41-50 (41-50 years), and G > 50 (51-66 years). Percentage progressive motility was significantly lower in G > 50 compared with G 21-30 . NAG, PSA, zinc, and fructose were significantly lower in G > 50 compared with G 21-30 . In a multiple regression analysis model, NAG and PSA showed positive significant association with percentage progressive motility. The opposite trend was found regarding zinc. No association between fructose and percentage progressive motility was shown. In this cross-sectional study, declined sperm motility observed in men over 50 years of age might be due to age-dependent changes in epididymal and accessory sex gland function.

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The Influence of Aging on Plasma Sex Hormones in Men: The Telecom Study

Cited by 158 publications

References 0 publications

Diabetes mellitus, hyperglycaemia and cancer

Diabetes mellitus, hyperglycaemia and cancer

Low Serum Testosterone Concentration in Middle-aged Men with Type 2 Diabetes

Association between Age and Epididymal and Accessory Sex Gland Function and their Relation to Sperm Motility

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