The Influence of Age on Fibromyalgia Symptoms

Cronan, Terry A.; Serber, Eva R.; Walen, Heather R.; Jaffe, Michael

doi:10.1177/08964302014003004

Cited by 44 publications

(42 citation statements)

References 33 publications

(35 reference statements)

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“…This could be explained by the fact that people of different ages have difference illness perceptions and expectancy. Although the prevalence of FM goes up with age, older people report less severe symptoms [43]. They may also be more likely to regard pain as part of the ageing process, to have less anxiety associated with this, and to cope with it better [43].…”

Section: Discussionmentioning

confidence: 99%

“…Although the prevalence of FM goes up with age, older people report less severe symptoms [43]. They may also be more likely to regard pain as part of the ageing process, to have less anxiety associated with this, and to cope with it better [43]. Whether this age-related placebo effect in FM is related to experience, social ability and other contextual factors deserves further study.…”

Section: Discussionmentioning

confidence: 99%

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The placebo effect and its determinants in fibromyalgia: meta-analysis of randomised controlled trials

et al. 2017

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The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a placebo and/or a no-treatment (observation only or waiting list) control group. Placebo effect size (ES) for pain and other outcomes was measured as the improvement of each outcome from baseline divided by the standard deviation of the change from baseline. This effect was compared with changes in the no-treatment control groups. Meta-analysis was undertaken to combine data from different studies. Subgroup analysis was conducted to identify possible determinants of the placebo ES. A total of 3912 studies were identified from the literature search. After scrutiny, 229 trials met the inclusion criteria. Participants who received placebo in the RCTs experienced significantly better improvements in pain, fatigue, sleep quality, physical function, and other main outcomes than those receiving no treatment. The ES of placebo for pain relief was clinically moderate (0.53, 95%CI 0.48 to 0.57). The ES increased with increasing strength of the active treatment, increasing participant age and higher baseline pain severity, but decreased in RCTS with more women and with longer duration of fibromyalgia. In addition, placebo treatment in RCTs is effective in fibromyalgia. A number of factors (expected strength of treatment, age, gender, disease duration) appear to influence the magnitude of the placebo effect in this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The placebo effect and its determinants in fibromyalgia: meta-analysis of randomised controlled trials

et al. 2017

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“…We hypothesized that patients who report perceived injustice from doctors or nurses would also report greater perceived stress and pain than patients who did not report perceived injustice. In addition, we controlled for age and gender because research has shown them to be confounding variables in patients with pain (Brousseau et al, 2010; Cronan, Serber, Walen, & Jaffe, 2002; Sanders, Labott, Molokie, Shelby, & Desimone, 2010; Tripp, VanDenKerkhof, & McAlister, 2006). …”

Section: Introductionmentioning

confidence: 99%

Perceived Injustice Predicts Stress and Pain in Adults with Sickle Cell Disease

Ezenwa¹,

Molokie²,

Wilkie³

et al. 2015

Pain Management Nursing

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Background Research evidence shows that perceived injustice is a context-based unfair treatment that has negative influence on health outcomes. Aims We examined the contribution of patients’ perceived injustice regarding interactions with healthcare providers to stress and pain in adults with sickle cell disease (SCD). Design This study was a cross-sectional correlational pilot study. Setting Included in the study were adults with SCD who received their care from a university-affiliated Comprehensive Sickle Cell Clinic. Participants/Subjects Participants were 52 adults whose mean age was 34 ±11 years (minimum [min] 20 years, maximum [max] 70 years). Most of the patients were African Americans (n = 48, 92%) and female (n = 41, 79%). Forty-eight patients (92%) reported having a high school diploma or higher. Methods Participants completed the perceived injustice questionnaire, perceived stress questionnaire, and the PAINReportIt, which includes questions to measure pain and demographics. We analyzed the data using the linear regression analyses. Results Perceived injustice from doctors was a significant predictor of perceived stress, p<.001 and pain, p=.002. Perceived injustice from nurses also was a significant predictor of perceived stress, p<.001 and pain, p=.02. The procedural, distributive, and informational domains of perceived injustice attributed to both doctors and nurses consistently predicted patients’ perceived stress, but only the procedural and distributive domains of perceived injustice consistently predicted patients’ pain. Conclusions Findings suggest that perceived injustice was negatively associated with stress and pain in adults with SCD and warrant further investigation in a larger sample.

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“…Four other studies reported the results of surveys or record reviews showing that elders with FM were more depressed and less physically active than elders without FM [7], and that the burden of symptoms was either reduced with increasing age [8], or remained high [2,9]. Associated problems of sleep disruption and isolation at home because of pain also were reported [2,9].…”

Section: Introductionmentioning

confidence: 99%

Characterization of fibromyalgia symptoms in patients 55–95 years old: a longitudinal study showing symptom persistence with suboptimal treatment

et al. 2014

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BACKGROUND Fibromyalgia (FM) has been understudied in the elderly population, a group with particular vulnerabilities to pain, reduced mobility, and sleep disruption. AIMS To characterize FM symptoms and treatments in a cohort of older subjects examined over time to determine the extent to which current, community-based treatment for older FM patients is in accord with published guidelines, and effective in reducing symptoms. METHODS A longitudinal, observational study of 51 subjects with FM (range 55 to 95 years) and 81 control subjects (58 to 95 years) performed at Banner Sun Health Research Institute in Sun City, AZ. Serial history and examination data were obtained over a 6-year period. FM data included medical history, medications, physical examination, tender point examination, neuropsychological testing, sleep and pain ratings, the Physical Function Subscale of the Fibromyalgia Impact Questionnaire, and other standardized scales to evaluate depression and other psychiatric symptoms, and cognitive and functional impairment. RESULTS Pain and stiffness that interfered with physical activity, sleep, and mood were reported by 80% or more of subjects. Over time, pain involved an increasing number of body areas. Over half of subjects were treated with NSAIDs, one-quarter with opioids, and one-quarter with estrogen. Few were treated with dual-acting antidepressants or pregabalin. DISCUSSION In this cohort of elders with suboptimally treated FM, substantial persistence of symptoms was seen over time. In general, recommended treatments were either not used or not tolerated. CONCLUSIONS Age-appropriate treatments as well as education of primary care providers are needed to improve treatment of FM in the older population.

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The Influence of Age on Fibromyalgia Symptoms

Abstract: There were significant differences among the age groups in most of the variables: With increasing age symptom duration increased but FMS symptomatology decreased. No age differences were found among the psychosocial mediators. The results suggest that the effects of FMS decrease over time.

Cited by 44 publications

References 33 publications

The placebo effect and its determinants in fibromyalgia: meta-analysis of randomised controlled trials

The placebo effect and its determinants in fibromyalgia: meta-analysis of randomised controlled trials

Perceived Injustice Predicts Stress and Pain in Adults with Sickle Cell Disease

Characterization of fibromyalgia symptoms in patients 55–95 years old: a longitudinal study showing symptom persistence with suboptimal treatment

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