The influence of age and sex on bone resorption of secondary hyperparathyroidism in renal osteodystrophy

He, Meema; Dg, Oreopoulos; Pr, Uldall

doi:10.1007/bf02405290

Cited by 14 publications

(4 citation statements)

References 13 publications

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“…Two separate stages are also reported concerning sub periosteal resorption in females [Meema et al" 1984], Sub periosteal resorption is usually connected with the higher serum parathyroid hormone level, which females have been reported to have in comparison to males [Rilz et al, 1973].…”

Section: Discussionmentioning

confidence: 99%

Influence of Thioacetamide-Provoked Liver Injury on Female Rat Blood and Alveolar Bone under Stress

Virtanen¹,

Lassila²

1986

Cells Tissues Organs

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Experimental liver injury with different stages was induced to adult female test rats with daily injection of thioacetamide (ThAA). The doses administered intraperitoneally were 50 mg/kg body weight. In the liver sections progressive changes of damage, regeneration and fat substitution were noticed. Kidney sections revealed enhanced glomerular atrophy, particularly in the cortical tubules, provoked in the 3-week traumatization period. The influence of ThAA on female rat blood was assayed using standard biochemical methods. The analyses done were: the percentage of blood obtainable and the serum/blood ratio; the serum alanine transferase; serum alkaline phosphatase; serum creatinine; serum hydroxyproline and serum β-glucuronidase activity in the acute, subacute, chronic and highly chronic stage of liver injury. The biochemical findings show continuously progressing damages when traumatization proceeds. In the 3-week test period the histological findings processed showed an increase in osteoclastic resorption in the alveolar bone around the occlusally stressed tooth simultaneously with a horizontal bone loss. Some indications of recovering incidents were seen, too. Only in the histological findings was no difference seen in the deterioration between both sexes, contrarily to the biochemical results also discussed in this study.

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Section: Discussionmentioning

confidence: 99%

Influence of Thioacetamide-Provoked Liver Injury on Female Rat Blood and Alveolar Bone under Stress

Virtanen¹,

Lassila²

1986

Cells Tissues Organs

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“…Nevertheless, it is apparent that a minority have severe bone disease whether this is judged by bone histology,} 2 radiographic findings,3 4 or symptoms.4 Surprisingly little is known about the factors that determine which patients will develop severe bone disease, although such knowledge might be of value in understanding the pathogenesis of the disorder, predicting which patients are at risk, and planning prophylaxis. Factors considered have included the age and sex of patients3 [5][6][7] and the duration and nature of their renal disease,3 4 89 but the interrelations between these putative risk factors are not clear. To define the characteristics of the population susceptible to bone disease we examined the interrelations between renal bone disease and various demographic features of a large, unselected series of patients with end stage uraemia.…”

Section: Introductionmentioning

confidence: 99%

Who gets renal bone disease before beginning dialysis?

Cundy¹,

Hand²,

Oliver³

et al. 1985

BMJ

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To identify patients at risk from renal bone disease we compared the demographic characteristics of 243 patients with end stage renal failure grouped according to the presence (97 (40%)) or absence of severe renal bone disease as judged by histological criteria. Youth, female sex, tubulointerstitial types of nephropathy, and a long duration of uraemia were all identified as significant independent risk factors for the development of bone disease. The relative risks from being female and having tubulointerstitial renal disease were separately identifiable when the estimated observation of renal failure was short (less than four years).

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“…Hyperparathyroid bone lesions are more marked in young age and in the female sex [57], In older individuals the extent of hyperparathyroid lesions, like osteoclastic surface, is generally lower in spite of elevated levels of iPTH. suggesting a lesser sensitivity with age of osteoblastic cells, the bone cells with PTH receptors, to PTH action [58,59].The damage to the skeleton due to [T-microglobulin amyloid deposition is a complication of long-term hemodi alysis. Lesions are mainly focal, radiographically charac terized by cysts or erosions, affecting mainly subchondral bone and are exclusively seen in the vicinity of synovial joints [60], This lesion may coexist with the osteodystrophic patterns described above.…”

mentioning

confidence: 99%