The influence of age and some inducers on udp-glucuronyltransferase activity

Plewka, Andrzej; Kamiński, Marian; Plewka, Danuta

doi:10.1016/s0531-5565(96)00124-6

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…In isolated perfused livers from 3- to 6- or 22- to 24-mo-old rats exposed to p -nitrophenol, there was evidence of reduced oxidation and glucuronidation with aging, which was speculated to be partly attributed to reduced cofactor availability (57). In contrast, no obvious effect of aging was reported in human (58) or rat (59) microsomal UGT activities in response to commonly prescribed medications. In more-recent publications, the individual or interactive effects of aging and sex on a wider range on xenobiotic metabolizing enzymes were examined.…”

Section: Etiology Of the Heterogeneity In Flavonoid Admementioning

confidence: 90%

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Cassidy

Minihane

2017

The American Journal of Clinical Nutrition

395

287

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At a population level, there is growing evidence of the beneficial effects of dietary flavonoids on health. However, there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide interindividual variability in flavonoid absorption and metabolism. Flavonoids are extensively metabolized by phase I and phase II metabolism (which occur predominantly in the gastrointestinal tract and liver) and colonic microbial metabolism. A number of factors, including age, sex, and genotype, may affect these metabolic processes. In addition, food composition and flavonoid source are likely to affect bioavailability, and emerging data suggest a critical role for the microbiome. This review will focus on the current knowledge for the main subclasses of flavonoids, including anthocyanins, flavonols, flavan-3-ols, and flavanones, for which there is growing evidence from prospective studies of beneficial effects on health. The identification of key factors that govern metabolism and an understanding of how the differential capacity to metabolize these bioactive compounds affect health outcomes will help establish how to optimize intakes of flavonoids for health benefits and in specific subgroups. We identify research areas that need to be addressed to further understand important determinants of flavonoid bioavailability and metabolism and to advance the knowledge base that is required to move toward the development of dietary guidelines and recommendations for flavonoids and flavonoid-rich foods.

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Section: Etiology Of the Heterogeneity In Flavonoid Admementioning

confidence: 90%

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Cassidy

Minihane

2017

The American Journal of Clinical Nutrition

395

287

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“…Although basal expression patterns may not accurately reflect the capacity for phytochemical induction, overall UGT activity may depend on both uninduced and induced protein levels, particularly in the context of weak activators/inhibitors. Sex, age, race, and exposures, such as tobacco smoke, have also been shown to affect rates of glucuronidation (11,(202)(203)(204). Another important factor that regulates interindividual metabolic differences is the presence of genetic polymorphisms in biotransformation enzymes.…”

Section: Factors That May Modify Phytochemical Induction Of Ugtsmentioning

confidence: 99%

Phytochemical Regulation of UDP-Glucuronosyltransferases: Implications for Cancer Prevention

Saracino

Lampe

2007

Nutrition and Cancer

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Uridine 5'-diphospho-glucuronosyltransferases (UGTs) are Phase II biotransformation enzymes that metabolize endogenous and exogenous compounds, some of which have been associated with cancer risk. Many phytochemicals have been shown to induce UGTs in humans, rodents, and cell culture systems. Because UGTs maintain hormone balance and facilitate excretion of potentially carcinogenic compounds, regulation of their expression and activity may affect cancer risk. Phytochemicals regulate transcription factors such as the nuclear factor-erythroid 2-related factor 2 (Nrf2), aryl hydrocarbon, and pregnane X receptors as well as proteins in several signal transduction cascades that converge on Nrf2 to stimulate UGT expression. This induction can be modified by several factors, including phytochemical dose and bioavailability and interindividual variation in enzyme expression. In this review, we summarize the knowledge of dietary modulation of UGTs, particularly by phytochemicals, and discuss the potential mechanisms by which phytochemicals regulate UGT transcription.

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Effects of model inducers on thyroxine UDP-glucuronosyl-transferase activity in vitro in rat and mouse hepatocyte cultures

Viollon-Abadie¹,

Bigot-Lasserre²,

Nicod³

et al. 2000

Toxicology in Vitro

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The influence of age and some inducers on udp-glucuronyltransferase activity

Cited by 4 publications

References 51 publications

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Phytochemical Regulation of UDP-Glucuronosyltransferases: Implications for Cancer Prevention

Effects of model inducers on thyroxine UDP-glucuronosyl-transferase activity in vitro in rat and mouse hepatocyte cultures

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