The influence of aerobic fitness on electrocardiographic and heart rate variability parameters in young and older adults

Dorey, Tristan W.; O’Brien, Myles W.; Kimmerly, Derek S.

doi:10.1016/j.autneu.2019.01.004

Cited by 11 publications

(14 citation statements)

References 24 publications

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“…Overall, the majority of individuals (57%) presented with clinically defined bradycardia during UDS. 25 RR-interval significantly increased in the whole cohort (adjusted mean difference, -0.09; 95% CI,-0.14 to -0.03 ; P =0.002 ; Figure 2A and B ) and in individuals with cervical SCI (adjusted mean difference, -0.12; 95% CI, -0.23 to 0.02; P =0.01) in response to bladder filling during UDS. There was no change in RR-interval in response to bladder filling during UDS in individuals with thoracic SCI (adjusted mean difference, -0.06; 95% CI, -0.17 to 0.04, P =0.31).…”

Section: Resultsmentioning

confidence: 96%

“…Overall, the majority of individuals (57%) presented with clinically defined bradycardia during UDS. 25 RR-interval significantly increased in the whole cohort (adjusted mean difference, -0.09; 95% CI,-0.14 to -0.03 ;P=0.002 ;Figure 2A and B Cervical SCI also had significant increases in SD1 (adjusted mean difference, -14.2; 95% CI, -27.3 to -1.2, P<0.05) and SD2 (adjusted mean difference, -34.6; 95% CI, -63 to -6.3, P<0.05). SD1 did not differ in thoracic SCI (adjusted mean difference, -6.8; 95% CI, -19.9 to 6.2, P=0.48).…”

Section: Resultsmentioning

confidence: 99%

“…HRV was assessed using time and frequency domain analysis in accordance with the European task force HRV guidelines 23 and as described elsewhere. 24,25 Briefly, ECG filtering and R-wave detection was performed using LabChart (ADInstruments, V8, Colorado Springs, CO, USA). The RR interval time series were obtained over 4-5-minute segments during supine rest and UDS at baseline and post-treatment.…”

Section: Methodsmentioning

confidence: 99%

“…27 The same segments were subsequently used for frequency domain analysis using Welch's method with 50% windowing. 24,25 The periodogram of each segment was then calculated using the Fourier transformation. Total power of each periodogram was measured as a total index of HRV, which is determined by the integral over the entire frequency range.…”

Section: Heart Rate Variability Analysismentioning

confidence: 99%

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Reduced Reflex Autonomic Responses following Intradetrusor OnabotulinumtoxinA Injections: A pre/post study in Individuals with Cervical and Upper Thoracic Spinal Cord Injury

Walter

Krassioukov

2021

Preprint

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Importance: Urodynamic studies (UDS) can provoke autonomic dysreflexia (AD) in individuals with spinal cord injury (SCI) at and above the sixth thoracic (T6) spinal segment potentially leading to profound vagally mediated heart rate reductions. Intradetrusor onabotulinumtoxinA injections have been shown to reduce AD events during UDS in this cohort but evidence is lacking whether this treatment can improve reflex autonomic responses. Objective: To assess the effects of intradetrusor onabotulinumtoxinA injections on heart rate variability (HRV) responses to UDS in individuals, 18-65 years of age, with chronic (>1-year) SCI at or above T6 with confirmed neurogenic detrusor overactivity and AD during UDS. Design, Setting, and Participants: This cohort study used participants from our recent prospective phase IV clinical trial. Individuals were screened at an academic medical centre between November 2014 and December 2019. After enrollment, participants underwent UDS prior to (i.e., baseline) and one month after intradetrusor onabotulinumtoxinA injections (post-treatment). Interventions: OnabotulinumtoxinA (200 U) was injected into the detrusor muscle at 20 sites (10 U/site). Main Outcomes and Measures: Continuous electrocardiogram (ECG) and blood pressure (BP) recordings were used to assess RR-interval, time and frequency domain metrics of HRV (a surrogate marker of autonomic nervous system activity), and AD pre- and post-intervention. Results: A total of 19 participants with SCI (5 women; mean [SD] age 42 [8.3] years) with complete ECG and BP data sets were suitable for autonomic analysis. During baseline UDS, an increase in RR-interval (adjusted mean difference, -0.08; 95% CI, -0.14 to -0.03; P=0.002) as well as time and frequency domain metrics of HRV were detected. Vagally mediated increases in high frequency (HF) power during UDS were larger in participants with cervical SCI compared to upper thoracic SCI (adjusted mean difference, 20.3; 95% CI, 3.3 to 37.2; P=0.013). Intradetrusor onabotulinumtoxinA injections significantly reduced time domain metrics of HRV and HF power (adjusted mean difference, 9.1; 95% CI, 3.1 to 15.1, P<0.01) responses to UDS across all participants. Conclusions and Relevance: Changes in HRV during UDS could be a potential indicator of improved autonomic cardiovascular function following interventions such as intradetrusor onabotulinumtoxinA injections.

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Section: Resultsmentioning

confidence: 96%

“…Overall, the majority of individuals (57%) presented with clinically defined bradycardia during UDS. 25 RR-interval significantly increased in the whole cohort (adjusted mean difference, -0.09; 95% CI,-0.14 to -0.03 ;P=0.002 ;Figure 2A and B Cervical SCI also had significant increases in SD1 (adjusted mean difference, -14.2; 95% CI, -27.3 to -1.2, P<0.05) and SD2 (adjusted mean difference, -34.6; 95% CI, -63 to -6.3, P<0.05). SD1 did not differ in thoracic SCI (adjusted mean difference, -6.8; 95% CI, -19.9 to 6.2, P=0.48).…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Heart Rate Variability Analysismentioning

confidence: 99%

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Reduced Reflex Autonomic Responses following Intradetrusor OnabotulinumtoxinA Injections: A pre/post study in Individuals with Cervical and Upper Thoracic Spinal Cord Injury

Walter

Krassioukov

2021

Preprint

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“…In contrast to previous research, aerobic fitness (6-MWT) was not a relevant predictor for HRV in our regression models. Dorey et al ( 2019 ) reported higher HF power in aerobically fit compared to aerobically unfit older adults. Thereby, aerobic fitness was determined as VO 2 peak in a graded cycle ergometer test.…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability Mainly Relates to Cognitive Executive Functions and Improves Through Exergame Training in Older Adults: A Secondary Analysis of a 6-Month Randomized Controlled Trial

Eggenberger

Annaheim

Kündig

et al. 2020

Front. Aging Neurosci.

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Heart rate variability (HRV) mirrors autonomic nervous system activities and might serve as a parameter to monitor health status in older adults. However, it is currently unknown which functional health measures, including cognitive, physical, and gait performance parameters, are most strongly related to HRV indices. This knowledge would enable implementing HRV assessments into health monitoring routines and training planning for older adults. Simultaneous cognitive–motor and exergame training may be effective to improve HRV indices but has not been investigated yet. Eighty-nine healthy older adults (≥70 years of age) were randomized into three groups: (1) virtual reality video game dancing, i.e., exergaming (DANCE); (2) treadmill walking with simultaneous verbal memory training (MEMORY); or (3) treadmill walking only (PHYS). Strength and balance exercises complemented each program. Over 6 months, two weekly 1-h training sessions were performed. HRV indices (standard deviation of N–N intervals, SDNN; root mean square of successive R–R interval differences, RMSSD; and absolute power of high-frequency band (0.15–0.4 Hz), HF power) and various measures of cognitive, physical, and gait performance were assessed at baseline and after 3 months and 6 months. Multiple linear regression analyses with planned comparisons were calculated. At baseline, 8–12% of HRV variance was significantly explained by cognitive executive functions and leg strength (inversely related). Verbal long-term memory, aerobic and functional fitness, and gait performance did not contribute to the model (SDNN: R 2 = 0.082, p = 0.016; RMSSD: R 2 = 0.121, p = 0.013; HF power: R 2 = 0.119, p = 0.015). After 6 months, DANCE improved HRV indices, while MEMORY and PHYS did not (time × intervention interactions: first-contrast DANCE/MEMORY vs. PHYS: SDNN p = 0.014 one-tailed, Δ R 2 = 0.020 and RMSSD p = 0.052 one-tailed (trend), Δ R 2 = 0.007; second-contrast DANCE vs. MEMORY: SDNN p = 0.002 one-tailed, Δ R 2 = 0.035, RMSSD p = 0.017 one-tailed, Δ R 2 = 0.012, and HF power p = 0.011 one-tailed, Δ R 2 = 0.013). We conclude that mainly cognitive executive functions are associated with HRV indices and that exergame training improves global and parasympathetic autonomic nervous system activities in older adults. Periodic assessments of HRV in older citizens could be particularly beneficial to monitor cognitive health and provide indications for preventative exercise measures.

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Atrial Fibrillation

Mandsager¹,

Phelan²

2021

Sports Cardiology

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The influence of aerobic fitness on electrocardiographic and heart rate variability parameters in young and older adults

Cited by 11 publications

References 24 publications

Reduced Reflex Autonomic Responses following Intradetrusor OnabotulinumtoxinA Injections: A pre/post study in Individuals with Cervical and Upper Thoracic Spinal Cord Injury

Reduced Reflex Autonomic Responses following Intradetrusor OnabotulinumtoxinA Injections: A pre/post study in Individuals with Cervical and Upper Thoracic Spinal Cord Injury

Heart Rate Variability Mainly Relates to Cognitive Executive Functions and Improves Through Exergame Training in Older Adults: A Secondary Analysis of a 6-Month Randomized Controlled Trial

Atrial Fibrillation

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