The Influence of Acute Hypothermia on the Rate of Oxygen Consumption and Glycogen Content of the Liver and on the Blood Glucose

Fuhrman, Frederick A.; Crismon, J. M.

doi:10.1152/ajplegacy.1947.149.3.552

Cited by 29 publications

(9 citation statements)

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“…2 the blood glucose of rats significantly increased during the early phase of hypothermia. This observation is in accord with those of FUHRMAN andCRISMON (1947) andPOPOVIC (1960). The former authors found that the increase in blood glucose was observed only for fed rats.…”

Section: Discussionsupporting

confidence: 91%

“…Blood glucose and free fatty acids are known as the major fuels for shivering thermogenesis, the primary means of heat production in acute cold exposure in rats . Changes in energy substrates for heat production have been investigated for hypothermic homeotherms (FUHRMAN and CRISMON, 1947;PoPoviC, 1960;DEPOCAS, 1962). However, no measurements have been reported on the simultaneous variations in the gas exchange and energy substrates metabolism during hypothermia.…”

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confidence: 99%

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Difference in the mode of acute cold-induced hypothermia between rat and hamster.

1987

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The present work was undertaken to elucidate the underlying causative factors limiting survival in hypothermic rats (non-hibernator) and hamsters (hibernator). A variety of physiological and biochemical parameters were measured for 28 male Wistar rats (205-286 g) and 26 male golden hamsters (85-118 g) before and during induction of hypothermia to colonic temperature (Tco) of 18°C. With progressive decreases in Tco, parallel falls in Vo2, Vco2, and heart rate were observed. In rats, plasma pH (pH) in arterial blood was significantly lowered from 7.453 at Tco of 38°C to 7.327 at Tco of 18°C (p <0.001). From the observations of increased arterial P~o2 and bound CO2 (bicarbonate ion) concentration, together with the unchanged blood lactate, respiratory acidosis caused by hypoventilation was suggested to be responsible for the decrease in pH. In contrast to rats, in hamsters pH , was almost unchanged during the induction of hypothermia, while nearly complete depletion of blood glucose (-84.6%) and liver glycogen (-99.5%) were observed when Tco of 38°C was lowered to 18°C. It is concluded that the decrease in pH p is a limiting factor for rats to survive the deep hypothermia at Tco of 18°C and the exhaustion of carbohydrates as an energy supply for hamsters. Under severe cold, when heat loss surpasses heat production progressive hypothermia will lead to death of homeothermic animals unless properly rectified. Systematic studies of the physiological changes dung hypothermia are necessary to identify the mechanisms for the failure in homeostasis as well as the inability to recover from it. Although many studies have been made on the underlying potential factors limiting survival in the hypothermic state, the cause of death due to acute hypothermia is controversial and still not completely understood (PREWITT et al.,

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Difference in the mode of acute cold-induced hypothermia between rat and hamster.

1987

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Section: Body Temperature Regulationmentioning

confidence: 99%

“…Hypothermic-related serum amylases elevations, leading to oedematous or necrohemorrhagic pancreatitis, is often found in necropsy studies of hypothermic patients [15]. The relationship between pancreatitis and hypothermia has not yet been solved, although it has been implicated in ischemia secondary to shock, previous and abusive alcohol intake or the presence of gallstones [15,26]. Other gastrointestinal alterations that can be found in hypothermia are: Multiple punctate erosions of low haemorrhagic (Wischnevsky ulcers) in the stomach, ileum and colon; probably related to the release thologies, mortality can reach up to 75% [15].…”

Section: Body Temperature Regulationmentioning

confidence: 99%

“…This hypotension is due to dehydration, increased production of nitric oxide which has a vasodilatory function and a shift of heated blood from central circulation to the peripheral circulation to dissipate heat [8,20]. Hypohydration consequently produces cardiovascular strain of vasoactive amines such as histamine and serotonin and the reperfusion after the cold-induced collapse of the microvasculature [15,19,26]. These Wischnevsky's lesions are seen in 80% of hypothermic patients [19].…”

Section: Effects Of Extreme Heat In the Organismmentioning

confidence: 99%

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Human Physiology in Extreme Heat and Cold

Beker¹,

Camila²,

De³

et al. 2018

Int Arch Clin Physiol

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The interest in the human body physiological capacity to adapt to extreme heat and cold conditions has increased enormously in the last few decades because of global warming and the consequent changing temperatures. The human body has multiple thermoregulatory mechanisms to counter the external extreme temperatures whose main objective is to keep temperature homeostasis within normal values. As exposure time to these stressful conditions increases and the external temperature becomes even more extreme, the body systems start adapting to its environment progressively. All of the adaptations, at the beginning of the exposure somewhat irrelevant, may become very important since they can affect all of the body systems in a negative manner and finally, compromise life. Clinically, all of these responses and adaptations are manifested through clinical signs and symptoms. The purpose of this paper is to discuss how human physiology adapts during extreme heat and cold conditions to maintain temperature homeostasis and its consequences when this cannot be achieved.

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Accidental Hypothermia

Fruehan¹

1960

Arch Intern Med

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The Influence of Acute Hypothermia on the Rate of Oxygen Consumption and Glycogen Content of the Liver and on the Blood Glucose

Cited by 29 publications

References 0 publications

Difference in the mode of acute cold-induced hypothermia between rat and hamster.

Difference in the mode of acute cold-induced hypothermia between rat and hamster.

Human Physiology in Extreme Heat and Cold

Accidental Hypothermia

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