The Influence of Acute and Chronic Renal Failure on the Enzymes of the Urea Cycle and the Protein Content in Leucocytes and Liver in Human and Animal Models

Vlaho, M; Harsanyi, Paul G.; Vogl, P.; Kaszian, L.

doi:10.1159/000410810

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Common non-essential PFAAs Orn, Asp, and Glu all take part in the Orn cycle (urea cycle). Urea cycle is a pivotal PFAA metabolic pathway whose dysregulation has been observed in a large number of diseases, such as infections [ 34 ], cancer [ 35 ] and metabolic diseases [ 36 ]. It is widely known that ammonia is normally converted to urea through urea cycle.…”

Section: Discussionmentioning

confidence: 99%

The association between plasma free amino acids and type 2 diabetes mellitus complicated with infection in Chinese patients

Zhang,

Luo,

Wang

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background Type 2 diabetes mellitus (T2DM), one of the most common public diseases threatening human health, is always accompanied by infection. Though there are still a variety of flaws in the treatment of some infectious diseases, metabolomics provides a fresh perspective to explore the relationship between T2DM and infection. Our research aimed to investigate the association between plasma free amino acids (PFAAs) and T2DM complicated with infection in Chinese patients. Methods A cross-sectional study was conducted from May 2015 to August 2016. We retrieved the medical records of 1032 inpatients with T2DM from Liaoning Medical University First Affiliated Hospital and we used mass spectrometry to quantify 23 PFAAs. Infections contained 15 individual categories that could be retrieved from the database. Principal component analysis was used to extract factors of PFAAs. Multi-variable binary logistic regression was used to obtain odds ratios (OR) and their 95% confidence intervals (CI). Results Among 1032 inpatients,109 (10.6%) had infectious diseases. Six factors, accounting for 68.6% of the total variance, were extracted. Factor 4 consisted of Glu, Asp and Orn. Factor 5 consisted of Hcy and Pip. After adjusting for potential confounders, factor 4 was positively correlated with T2DM complicated with infection in Chinese T2DM patients (OR: 1.27, 95%CI: 1.06–1.52). Individual Hcy in factor 5 was positively associated with T2DM complicated with infection (OR: 1.33, 95%CI: 1.08–1.64). Furthermore, factor 4 (OR: 1.44, 95%CI: 1.11–1.87), Orn (OR: 1.01, 95%CI: 1.00-1.02) and Hcy (OR: 1.56, 95%CI: 1.14–3.14) were positively associated with bacterial infection in Chinese T2DM patients, while factor 5 (OR: 0.71, 95%CI: 0.50-1.00) was negatively associated with bacterial infection. Conclusions Urea cycle-related metabolites (Orn, Asp, Glu) and Hcy were positively associated with T2DM complicated with infection in China. Orn and Hcy were positively associated with bacterial infection in T2DM patients in China.

show abstract

Section: Discussionmentioning

confidence: 99%

The association between plasma free amino acids and type 2 diabetes mellitus complicated with infection in Chinese patients

Zhang,

Luo,

Wang

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…Common non-essential PFAAs Orn, Asp, and Glu all take part in the Orn cycle (urea cycle). Urea cycle is a pivotal PFAA metabolic pathway whose dysregulation has been observed in a large number of diseases, such as infections [33], cancer [34] and metabolic diseases [35]. It is widely known that ammonia is normally converted to urea through urea cycle.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Plasma Free Amino Acids and Type 2 Diabetes Mellitus complicated with infection in Chinese Patients

Zhang

Luo

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Type 2 diabetes mellitus (T2DM), one of the most common public diseases threatening human health, is always accompanied by infection. Though there are still a variety of flaws in the treatment of some infectious diseases, metabolomics provides a fresh perspective to explore the relationship between T2DM and infection. Our research aimed to investigate the association between plasma free amino acids (PFAAs) and the risk of T2DM complicated with infection in Chinese patients. Methods A cross-sectional study was conducted from May 2015 to August 2016.We retrieved the medical records of 1032 inpatients with T2DM from Liaoning Medical University First Affiliated Hospital and we used mass spectrometry to quantify 23 PFAAs. Infectious contained 15 individual categories that could be retrieved from the database. Principal component analysis was used to extract factors of PFAAs. Multi-variable binary logistic regression was used to obtain odds ratios (OR) and their 95% confidence intervals (CI). Results Among 1032 inpatients,109 (10.6%) had infectious diseases. Six factors, accounting for 68.6% of the total variance, were extracted. Factor 4 consisted of Glu, Asp and Orn. Factor 5 consisted of Hcy and Pip. After adjusting for potential confounders, factor 4 was positively correlated with increased risk of T2DM complicated with infection in T2DM (OR: 1.26, 95%CI: 1.05–1.52). Individual Hcy in factor 5 was positively associated with T2DM complicated with infection (OR: 1.32, 95%CI: 1.07–1.64). Furthermore, factor 4 (OR: 1.45, 95%CI: 1.12–1.88), Orn (OR: 1.01, 95%CI: 1.00-1.02) and Hcy (OR: 1.57, 95%CI: 1.14–2.15) were positively associated with bacterial infection in Chinese T2DM patients, while factor 5 (OR: 0.69, 95%CI: 0.49–0.99) was negatively associated with bacterial infection. Conclusions Urea cycle-related metabolites (Orn, Asp, Glu) and Hcy were positively associated with T2DM complicated with infection in China. Orn and Hcy were positively associated with bacterial infection in T2DM patients in China.

show abstract

The Influence of Acute and Chronic Renal Failure on the Enzymes of the Urea Cycle and the Protein Content in Leucocytes and Liver in Human and Animal Models

Cited by 2 publications

References 0 publications

The association between plasma free amino acids and type 2 diabetes mellitus complicated with infection in Chinese patients

The association between plasma free amino acids and type 2 diabetes mellitus complicated with infection in Chinese patients

The Association Between Plasma Free Amino Acids and Type 2 Diabetes Mellitus complicated with infection in Chinese Patients

Contact Info

Product

Resources

About