The Influence of Acidosis on the Utilization of Glucose by the Red Blood Cells in Shock

Some Changes in Metabolism Due to Acidosis in Shock

“…The relation of the glucose utilization lo the pH was evident from experiments where artificial medium of different pH was used. There is a similar relation between the glycolytic activity of the rat diaphragm and thepll as in the erythrocytes (13).…”

“…The greater the drop, the more intense was the trauma in Noble-Collip drum (NCD) and the higher was the level of lactic acid in the plasma. The decrease of glycolytic activity of erythrocytes in shock was caused by a marked increase in the lactic acid concentration but not by the lactate ion but by the hydrogen ion as has been shown (13). In this study we bring further evidence of the influence of acidosis on the metabolism in shock.…”

“…The experiments with rat diaphragm showed a similar dependence of the glycolytic activity upon Ihe pH as in Ihe erythrocytes (13). Kovach (4) found Ihe decreased utilization of glucose by the rat diaphragm in vitro after trauma or shock, but he did not show the real cause of it.…”

“…Moreover the factors which participate in the origin of these disorders are not clearly defined. In our previous studies (12,13) we have shown a significant decrease of glycolytic activity of erythrocytes due to trauma and shock. The greater the drop, the more intense was the trauma in Noble-Collip drum (NCD) and the higher was the level of lactic acid in the plasma.…”