The Influence of Accrual Volume and National Cancer Institute-Comprehensive Cancer Center (NCI-CCC) Designation on Outcome for the RTOG 91-11 Intergroup Trial for Laryngeal Preservation

Improving the Quality of Head and Neck Cancer Care

“…2 In a secondary analysis of the Radiation Therapy Oncology Group 3-arm study 91-11 for laryngeal preservation, patients treated at regional centers vs National Cancer Institute-designated comprehensive cancer centers had similar outcomes in time to laryngectomy and overall survival. 9 The findings from this analysis underscore the NCCN recommendation that enrollment in clinical trials should be encouraged. Although the secondary analysis of 91-11 data is still under way, it supports the supposition that well-designed trials with stringent quality control at each participating center can produce similar outcomes for patients regardless of the institution or patient volume.…”