The influence of a sustained 10‐day hypoxic bed rest on cartilage biomarkers and subchondral bone in females: The FemHab study

McDonnell, Adam C.; Eiken, Ola; Mekjavic, Igor B.; Žlak, Nik; Drobnič, Matej

doi:10.14814/phy2.14413

Cited by 8 publications

(14 citation statements)

References 53 publications

(83 reference statements)

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“…The following participants in the FemHab study reported menstruating during the interventions: HAMB participants 1, 2, 7, 9, 10 and 12; HBR: 1, 2, 5, 6, 7, 11 and 12; and NBR 3, 9, 11, 12, 15 and 16. The individual data for oestradial and progesterone have previously been published and are available as means ± SD in Table 2 of McDonnell, Eiken, Mekjavic, Zlak, & Drobnic (2020). Six participants (3, 5, 9, 10, 11 and 14) were taking hormonal contraceptives, while the remainder (1, 2, 4, 6, 7, 8, 12, 15 and 16) were naturally cycling.…”

Section: Resultsmentioning

confidence: 99%

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Do females and males exhibit a similar sarcopenic response as a consequence of normoxic and hypoxic bed rest?

Mekjavić

Eiken²,

Mekjavič

et al. 2020

Experimental Physiology

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This study investigated the effects of hypoxia on the known processes of adaptation of body composition and muscle function to normoxic inactivity. Females (n = 12) and males (n = 11) took part in the following interventions: hypoxic ambulation (HAMB; ∼4000 m); hypoxic bed rest (HBR; ∼4000 m) and normoxic bed rest (NBR). Prior to and immediately following each intervention, body composition, thigh and lower leg crosssectional area (CSA) and isometric muscular strength were recorded. Participants lost body mass (HAMB: male −1.5 ± 0.9 kg, female −1.9 ± 0.7 kg; HBR: male −2.0 ± 1.8 kg, female −2.4 ± 0.8 kg; NBR: male −1.4 ± 1.3 kg, female −1.4 ± 0.9 kg) and lean mass (HAMB: male −3.9 ± 3.0%, female −3.4 ± 2.0%; HBR: male −4.0 ± 4.4%, female −4.1 ± 2.0%; NBR: male −4.0 ± 3.4%, female −2.2 ± 2.7%) with no between-condition or sex differences. Knee extension decreased for males in NBR compared to HAMB (HAMB: male −0.2 ± 9.1%, female 1.3 ± 4.9%; HBR: male −7.8 ± 10.3%, female −3.3 ± 10.9%; NBR: male −14.5 ± 11%, female −3.4 ± 6.9%). Loss of force during maximal voluntary contraction (MVC) in the knee extensors was significantly different between males and females following NBR. There were no other significant changes noted following the experimental interventions. There were no differences recorded between sexes in maximal MVC for elbow or ankle joints. Female lower leg CSA decreased following bed rest (HAMB:-4.5 ± 2.0%; HBR:-9.9 ± 2.6%; NBR:-8.0 ± 1.6%). These findings indicate that a 10-day hypoxic bed rest does not exert any significant additional effect on muscle atrophy when compared to NBR, except for female thigh CSA. In contrast to males, who exhibited a significant loss of muscle strength, no such decrement in strength was observed in the female participants.

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Section: Resultsmentioning

confidence: 99%

“…Six participants were using hormonal contraception, while the remaining participants were naturally cycling. Detailed individual oestradiol and progesterone data have been published(McDonnell et al, 2020). Significant differences (P < 0.05): * vs. Post, † vs. HAMB.…”

mentioning

confidence: 99%

Do females and males exhibit a similar sarcopenic response as a consequence of normoxic and hypoxic bed rest?

Mekjavić

Eiken²,

Mekjavič

et al. 2020

Experimental Physiology

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“…In both FemHab and LunHab each intervention lasted 10 days, while in the PlanHab study, the interventions had a duration of 21 days. The detailed study protocols have been described elsewhere (Debevec et al, 2014;McDonnell et al, 2019McDonnell et al, , 2020. In the current study, data related to muscle function, muscle area, body composition, and caloric intake from the three individual studies were merged into a single database, where subjects were grouped according to the particular intervention, irrespective of the study of origin.…”

Section: General Study Designmentioning

confidence: 99%

“…Inclusion and exclusion criteria for PlanHab, LunHab, and FemHab have been described in detail elsewhere (Debevec et al, 2014;McDonnell et al, 2019McDonnell et al, , 2020, and those criteria followed the European Space Agency (ESA) guidelines (Heer et al, 2009). Briefly, following a reply to a national advertisement, participants were provided with a detailed document outlining the specifics of the study.…”

Section: Participantsmentioning

confidence: 99%

“…A unique opportunity to address individual variability upon bed rest responses is the Planica bed rest program, where three studies lasting 10 or 21 days have been performed using identical pre-and post-bed rest tests under strictly-controlled conditions (Keramidas et al, 2016;McDonnell et al, 2019McDonnell et al, , 2020. In the three studies, each participant completed three interventions [i.e., hypoxic ambulation (HAMB), normoxic bed rest (NBR), and hypoxic bed rest (HBR)] in a randomized, cross-over design.…”

Section: Introductionmentioning

confidence: 99%

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Substantial and Reproducible Individual Variability in Skeletal Muscle Outcomes in the Cross-Over Designed Planica Bed Rest Program

et al. 2021

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To evaluate the individual responses in skeletal muscle outcomes following bed rest, data from three studies (21-day PlanHab; 10-day FemHab and LunHab) were combined. Subjects (n = 35) participated in three cross-over campaigns within each study: normoxic (NBR) and hypoxic bed rest (HBR), and hypoxic ambulation (HAMB; used as control). Individual variability (SDIR) was investigated as √(SDExp2–SDCon2), where SDExp and SDCon are the standard deviations of the change score (i.e., post – pre) in the experimental (NBR and HBR) and the control (HAMB) groups, respectively. Repeatability and moderators of the individual variability were explored. Significant SDIR was detected for knee extension torque, and thigh and calf muscle area, which translated into an individual response ranging from 3 to −17% for knee extension torque, −2 to −12% for calf muscle area, and −1 to −8% for thigh muscle area. Strong correlations were found for changes in NBR vs. HBR (i.e., repeatability) in thigh and calf muscle area (r = 0.65–0.75, P < 0.0001). Change-scores in knee extension torque, and thigh and calf muscle area strongly correlated with baseline values (P < 0.001; r between −0.5 and −0.9). Orthogonal partial least squares regression analysis explored if changes in the investigated variables could predict calf muscle area alterations. This analysis indicated that 43% of the variance in calf muscle area could be attributed to changes in all of the other variables. This is the first study using a validated methodology to report clinically relevant individual variability after bed rest in knee extension torque, calf muscle area, and (to a lower extent) thigh muscle area. Baseline values emerged as a moderator of the individual response, and a global bed rest signature served as a moderately strong predictor of the individual variation in calf muscle area alterations.

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In vivo models of human articular cartilage mechanosensitivity

Mündermann,

Liphardt,

Herger

2024

Cartilage Tissue and Knee Joint Biomechanics

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The influence of a sustained 10‐day hypoxic bed rest on cartilage biomarkers and subchondral bone in females: The FemHab study

Cited by 8 publications

References 53 publications

Do females and males exhibit a similar sarcopenic response as a consequence of normoxic and hypoxic bed rest?

Do females and males exhibit a similar sarcopenic response as a consequence of normoxic and hypoxic bed rest?

Substantial and Reproducible Individual Variability in Skeletal Muscle Outcomes in the Cross-Over Designed Planica Bed Rest Program

In vivo models of human articular cartilage mechanosensitivity

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