The Influence of a High‐Fat Dietary Environment in the Fetal Period on Postnatal Metabolic and Immune Function

Abstract

articles integrative PhysiologyMethods and Procedures Mice C57BL/6J mice (4 weeks old; males: n = 24, females: n = 32) used in this study were purchased from Sankyo Laboratories (Tokyo, Japan). They were allowed free access to water and food, and were kept in a light-, temperature-, and humidity-controlled environment throughout the experiment (12-12 h light-dark cycle; temperature 23 ± 1 °C; 55 ± 5% relative humidity).This study was approved by the Institutional Animal Care and Use Committee at Japan Women's University, and the animals were maintained in accordance with the Guide for the Care and Use of Laboratory Animals guideline of the General Administrative Agency of the Japanese Cabinet. dietThe animals were fed two types of diet throughout the study. They were fed either the control diet (AIN-93G: American Institute of Nutrition 93G), or an HF diet (AIN-93G supplemented with lard), which consisted of 29% lard ad libitum as shown in Table 1.

Postnatal weight gain induced by overfeeding pups and maternal high-fat diet during the lactation period modulates glucose metabolism and the production of pancreatic and gastrointestinal peptides

“…Numerous recent studies have demonstrated the benefits of breastfeeding [1,13,33]. However, due to modern changes in diet, the fat composition of the maternal diet during lactation is high not only in western societies but also in Asia, new mothers consume far more fats and carbohydrates than they need [9].…”

Maternal high-fat diet programs Wnt genes through histone modification in the liver of neonatal rats

“…Recently, quite a few animal studies have indicated that a maternal high-fat (HF) diet increases offspring susceptibility to the later development of a metabolic syndrome-like phenotype (Singh et al 2003, Elahi et al 2009, Odaka et al 2010. In animal models of maternal HF feeding, offspring born to mothers fed a HF diet during gestation only or during gestation and lactation exhibited a markedly increased adiposity, metabolic disorders, poor glycemic control, insulin resistance, hepatic metabolic dysfunction, and development of nonalcoholic fatty liver disease (NAFLD; Bayol et al 2005, Ashino et al 2011.…”

Maternal conjugated linoleic acid supplementation reverses high-fat diet-induced skeletal muscle atrophy and inflammation in adult male rat offspring

“…The detrimental impact to the health of offspring can be lifelong, particularly when combined with additional stressors into adulthood (23,44). Although the actions of excessive dietary intake on infant health are complex, of particular interest is the role of saturated fat, which has been shown to elicit both inflammatory and metabolic dysfunction in both mother and offspring (37,47).…”