The influence of a cooked-meat meal on estimated glomerular filtration rate

Preiss, David; Godber, Ian M; Lamb, Edmund J.; Dalton, R. Neil; Gunn, I R

doi:10.1258/000456307779595995

Cited by 107 publications

(71 citation statements)

References 23 publications

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“…Vegetarian participants had lower urinary sulfate excretion, which can be accounted for by lesser intake of sulfurcontaining amino acids associated with lesser protein intake. Vegetarian participants also had a lower urinary creatinine excretion, which can be accounted for by lesser intake of creatinine in the form of cooked meat and also by a slightly higher percentage of women among the vegetarian participants (31). A particularly interesting finding was that average phosphate excretion was lower in vegetarian participants.…”

Section: Discussionmentioning

confidence: 90%

The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores

Patel

Luo

Plummer

et al. 2012

Clinical Journal of the American Society of Nephrology

182

140

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SummaryBackground and objectives The uremic solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) are generated by colon bacteria acting on food components that escape absorption in the small bowel. The production of these potentially toxic compounds may thus be influenced by diet. This study examined whether production of PCS and IS is different in vegetarians and omnivores.Design, setting, participants, & measurements The production of PCS and IS was assessed by measuring their urinary excretion rates in participants with normal kidney function. Studies were carried out in 15 vegetarians and 11 individuals consuming an unrestricted diet. Participants recorded food intake over 4 days and collected urine over the final 2 days of each of two study periods, which were 1 month apart.Results Average PCS excretion was 62% lower (95% confidence interval [95% CI], 15-83) and average IS excretion was 58% lower (95% CI, 39-71) in vegetarians than in participants consuming an unrestricted diet. Food records revealed that lower excretion of PCS and IS in vegetarians was associated with a 69% higher (95% CI, 20-139) fiber intake and a 25% lower (95% CI, 3-42) protein intake. PCS and IS excretion rates varied widely among individual participants and were not closely correlated with each other but tended to remain stable in individual participants over 1 month.Conclusions PCS and IS production rates are markedly lower in vegetarians than in individuals consuming an unrestricted diet.

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Section: Discussionmentioning

confidence: 90%

The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores

Patel

Luo

Plummer

et al. 2012

Clinical Journal of the American Society of Nephrology

182

140

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“…Circulating cystatin C concentrations are not influenced by ingestion of meat (16,17 ) or tubular secretion, and the influence of muscle mass on cystatin C concentrations is substantially smaller than its influence on creatinine concentrations (18 -23 ). Cystatin Cbased GFR-estimating (eGFR cystatin C ) equations, with simple formulations, therefore can often replace more complex eGFR creatinine equations, with vague and illdefined anthropometric variables such as race (2 ).…”

mentioning

confidence: 99%

Generation of a New Cystatin C–Based Estimating Equation for Glomerular Filtration Rate by Use of 7 Assays Standardized to the International Calibrator

et al. 2014

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BACKGROUND Many different cystatin C–based equations exist for estimating glomerular filtration rate. Major reasons for this are the previous lack of an international cystatin C calibrator and the nonequivalence of results from different cystatin C assays. METHODS Use of the recently introduced certified reference material, ERM-DA471/IFCC, and further work to achieve high agreement and equivalence of 7 commercially available cystatin C assays allowed a substantial decrease of the CV of the assays, as defined by their performance in an external quality assessment for clinical laboratory investigations. By use of 2 of these assays and a population of 4690 subjects, with large subpopulations of children and Asian and Caucasian adults, with their GFR determined by either renal or plasma inulin clearance or plasma iohexol clearance, we attempted to produce a virtually assay-independent simple cystatin C–based equation for estimation of GFR. RESULTS We developed a simple cystatin C–based equation for estimation of GFR comprising only 2 variables, cystatin C concentration and age. No terms for race and sex are required for optimal diagnostic performance. The equation, eGFR=130×cystatin C−1.069×age−0.117−7, is also biologically oriented, with 1 term for the theoretical renal clearance of small molecules and 1 constant for extrarenal clearance of cystatin C. CONCLUSIONS A virtually assay-independent simple cystatin C–based and biologically oriented equation for estimation of GFR, without terms for sex and race, was produced.

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“…10 However, when such a modest increase in creatinine is being used to define AKI, consideration needs to be given to factors that cause fluctuations in serum creatinine. One important factor is the consumption of a meat meal, which has been shown to increase serum creatinine by 20.5 mmol/L within 1 -2 h. 11 Other factors include biological and analytical variation. Reference change values (RCV) can be used to determine whether changes in serum creatinine are statistically significant by accounting for biological and analytical variation.…”

Section: Discussionmentioning

confidence: 99%

Detection of patients with acute kidney injury by the clinical laboratory using rises in serum creatinine: comparison of proposed definitions and a laboratory delta check

2011

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Background: Timely detection of acute kidney injury (AKI) in hospital patients has been hampered by the multiple definitions of AKI and difficulties applying their criteria. A laboratory delta check may provide an effective means of detecting patients developing AKI. This study compared three of the proposed AKI definitions and a delta check to detect AKI using serum creatinine results of hospital inpatients. Methods: Serum creatinine results for 2822 inpatients were gathered retrospectively from the clinical biochemistry database. All serum creatinine results within 30 d of admission were included for each patient and assessed for AKI according to four criteria: Risk, Injury, Failure (RIFLE), Acute Kidney Injury Network (AKIN), Waikar & Bonventre or a delta check (increase of .26 mmol/L between two successive values). Results: A total of 149 (11.3%) patients were defined as having AKI by at least one of the four criteria. Different populations of patients were identified by each criterion. The number of patients identified and the incidence of AKI were as follows: RIFLE 94 (7.1%), AKIN 125 (9.5%), Waikar & Bonventre 100 (7.6%) and delta check 146 (11.1%). The delta check detected 132 (98%) of all 135 cases detected by the other three criteria. A further 14 patients were detected solely by the delta check. Conclusions: The different definitions proposed for AKI detect different populations of patients. A laboratory delta check detected 98% of all the patients identified by AKIN, RIFLE and Waikar & Bonventre combined and could therefore provide a practical way of detecting AKI patients.

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The influence of a cooked-meat meal on estimated glomerular filtration rate

Abstract: Addresses

Cited by 107 publications

References 23 publications

The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores

The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores

Generation of a New Cystatin C–Based Estimating Equation for Glomerular Filtration Rate by Use of 7 Assays Standardized to the International Calibrator

Detection of patients with acute kidney injury by the clinical laboratory using rises in serum creatinine: comparison of proposed definitions and a laboratory delta check

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