The Influence of a chronic vitamin a deficiency on the acoustic sensory cells and the ganglion spirale cochleae of the rat

Löhle, E.

doi:10.1007/bf00453751

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…That antioxidant agents effectively reduce sensory cell death and NIHL has now been well demonstrated in animal studies using a variety of antioxidant agents, such as GSH/ glutathione monoethyl ester (GSHE) (Ohinata et al, 2000b;Kopke et al, 2002;Hight et al, 2003;Miller et al, 2003a), resveratrol (Seidman et al, 2003), allopurinol (Seidman et al, 1993;Cassandro et al, 2003), superoxide dismutase-polyethylene glycol (Seidman et al, 1993), U74389F (a lazaroid drug which inhibits lipid peroxidation and scavenges free radicals) (Quirk et al, 1994), and R-phenylisopropyladenosine (R-PIA) (Hu et al, 1997;Hight et al, 2003). Small protective effects of individual (or combined) dietary antioxidant nutrients are also well described for insults to the inner ear including noise, drugs, and age (Chole and Quick, 1976;Lohle, 1980Lohle, ,1985Romeo, 1985;Biesalski et al, 1990;Lopez-Gonzalez et al, 2000;Seidman, 2000;Bertolaso et al, 2001;Pasqualetti and Rijli, 2001;Teranishi et al, 2001;Rabinowitz et al, 2002;Hou et al, 2003;Derekoy et al, 2004;Kalkanis et al, 2004;Weijl et al, 2004;Ahn et al, 2005;McFadden et al, 2005;Yamashita et al, 2005a).…”

Section: Enhancing Antioxidant Defense Attenuates Nihlmentioning

confidence: 99%

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

et al. 2007

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Recent research has shown the essential role of reduced blood flow and free radical formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant late formation 7-10 days following noise exposure, and one mechanism underlying noise-induced reduction in cochlear blood flow has finally been identified. These new insights have led to the formulation of new hypotheses regarding the molecular mechanisms of NIHL; and, from these, we have identified interventions that prevent NIHL, even with treatment onset delayed up to 3 days post-noise. It is essential to now assess the additive effects of agents intervening at different points in the cell death pathway to optimize treatment efficacy. Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss.

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Section: Enhancing Antioxidant Defense Attenuates Nihlmentioning

confidence: 99%

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

et al. 2007

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Klinik der Innenohrschwerhörigkeiten

Lehnhardt

1984

Verhandlungsbericht 1984 Der Deutschen Gesellschaft Für Hals- Nasen- Ohren-Heilkunde, Kopf- Und Hals-Chirurgie

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The influence of chronic vitamin A deficiency on human and animal ears

Löhle¹

1982

Arch Otorhinolaryngol

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After feeding young rats a diet deficient in vitamin A, we examined the inner ear with the electron microscope. There were changes in the cuticle of the outer and inner hair cells. Furthermore, there were changes in the reticular system of the intermediate zone and massive degenerative changes in the ganglion cells of the VIII nerve. In a second experiment with older animals we found no significant changes in the sensory cells, though there was new bone formation in Rosenthal's canal and damage to the ganglion cells, of a lesser extent than was evident in the first experiment, however. In a further clinical study, we carefully chose human subjects suffering from alcoholic liver disease who also had a negative history of ear infection, noise exposure, head injury and use of streptomycin. Normal auditory function in the family was also a criterion. A decreased auditory function associated with low vitamin A levels was found in these patients. Those with liver disease showed not only a significant auditory dysfunction in the higher frequencies, but as well a poorer performance in the tone decay test. They were compared to a control group with normal hepatic, renal and thyroid status.

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The Influence of a chronic vitamin a deficiency on the acoustic sensory cells and the ganglion spirale cochleae of the rat

Cited by 6 publications

References 11 publications

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention

Klinik der Innenohrschwerhörigkeiten

The influence of chronic vitamin A deficiency on human and animal ears

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