The influence <i>in vitro</i> of deoxycorticosterone on glycogen formation in muscle

Verzár, F.; Wenner, V.

doi:10.1042/bj0420035

Cited by 51 publications

(13 citation statements)

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“…In these studies, muscle glycogen was somewhat less affected. Verzár & Wenner (1948) had already shown that glycogen was reduced by DOC in isolated rat diaphragm muscle, indicating glycogenolysis and, in this way, DOC opposed the actions of insulin. In later in vivo studies, this was found to be dose dependent, and in adrenalectomised rats (sustained for 3 days on 3 mg DOCA per day, then untreated for 24 h), a single dose of up to 2 mg DOCA was glycogenic, whereas 10 mg was less effective, and 20 mg inhibitory (Verzár & Wang 1950).…”

Section: Glucocorticoid Activitymentioning

confidence: 99%

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function

Vinson¹

2011

Journal of Endocrinology

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Over the 70 or so years since their discovery, there has been continuous interest and activity in the field of corticosteroid functions. However, despite major advances in the characterisation of receptors and coregulators, in some ways we still lack clear insight into the mechanism of receptor activation, and, in particular, the relationship between steroid hormone structure and function remains obscure. Thus, why should deoxycorticosterone (DOC) reportedly be a weak mineralocorticoid, while the addition of an 11b-hydroxyl group produces glucocorticoid activity, yet further hydroxylation at C18 leads to the most potent mineralocorticoid, aldosterone? This review aims to show that the field has been confused by the misreading of the earlier literature and that DOC, far from being relatively inactive, in fact has a wide range of activities not shared by the other corticoids. In contrast to the accepted view, the presence of an 11b-hydroxyl group yields, in corticosterone or cortisol, hormones with more limited functions, and also more readily regulated, by 11b-hydroxysteroid dehydrogenase. This interpretation leads to a more systematic understanding of structure-function relationships in the corticosteroids and may assist more rational drug design.

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Section: Glucocorticoid Activitymentioning

confidence: 99%

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function

Vinson¹

2011

Journal of Endocrinology

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“…Other workers have investigated various aspects of the metabolic changes in tissues after oestradiol, notably the effects on tissue arginase and phosphatase activity [Kochakian, 1946a[Kochakian, , 1947] and on glycogenolysis [Verzar & Wenner, 1948]. It is unlikely, however, that the overall effects of oestradiol administration can be explained in terms of the action of any one metabolic system.…”

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confidence: 98%

The Effects of Oestradiol on the Rat Uterus

Cole¹

1950

J Endocrinol

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1. The water and electrolyte changes in the uteri of spayed rats have been investigated after the administration of oestradiol-17 (\g=b\) and are found to fall into two main phases.2. 6\p=m-\10 hr. after the subcutaneous injection of the hormone the total water content increases, as a result of expansion of the extracellular fluid space and of the relative cell volume. The increase of the relative cell volume is caused by an increase of the idiomolar value.3. 18\p=m-\54 hr. after the injection the total water content increases again after a temporary fall. The water increase is now confined to the intracellular space. Total nucleoprotein and residual phosphorus increase, and it is suggested that the nucleoprotein phosphate groups are responsible for the increase of the electrostatic equivalent and hence the increased potassium concentration in the cells. The idiomolar value falls, and there is probably an increased formation of cell protein at this stage.

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“…They found that the oxygen consumption of slices of human cerebral cortex was maintained for a significantly longer period in the absence of a glucose substrate than was the oxygen consumption of rat brain, which dropped off rapidly. If this substrate is glycogen, the glycogenolytic potentiality of desoxycorticosterone reported by Verzar and Wenner (27) CMRo, or CMRco, was observed, indicating that desoxycorticosterone glucoside does not influence the aerobic phase of cerebral energy metabolism as an immediate general effect, although it may alter the substrate. However, it is interesting that the cerebral metabolic rate was diminished following administration of DCG in all but one ortho-steroidal subject and that no change or only a slight increase in cerebral metabolic rate was apparent in all hyposteroidal subjects.…”

Section: Methodsmentioning

confidence: 94%

Effect of Desoxycorticosterone Glucoside Upon Cerebral Blood Flow and Metabolism of Human Subjects 1

Bentinck¹,

Gordan²,

Adams³

et al. 1951

J. Clin. Invest.

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An effect of steroidal hormones up)on cerebral metabolism was suggested by Selye's (1) observationl that steroids possess anesthetic properties when administered to experimental animals. Gordan and Elliott (2) ( 17,18), for the determination of cerebral blood flow in man. An estimation of the rate of cerebral blood flow permiiits a computation of the rate of utilization or production by the brain of any substance which canl be accurately analyzed in 1loo00.A steroidal compotund well adapted for use in short-term studies in miian is also available in the potent, water-soluble desoxycorticosterone glucoside (DCG). ' The conjunction of a workable miethod for the estimationi of the rate of cerebral blood flow and an active, water-soluble steroid has made feasible a measureml-ent of steroidal effects on the metabolism of the human brain inv aiVo. METHODCerebral blood flow (CBF) and cerebral metabolic rate (CMR) were estimated in 15 human subjects by the original nitrous oxide method of Kety and Schmidt (17,

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The influence in vitro of deoxycorticosterone on glycogen formation in muscle

Cited by 51 publications

References 3 publications

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function

The Effects of Oestradiol on the Rat Uterus

Effect of Desoxycorticosterone Glucoside Upon Cerebral Blood Flow and Metabolism of Human Subjects 1

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