The influence and impact of smoking on red blood cell morphology and buccal microflora: A case‐control study

Aldosari, Khalid Hadi; Ahmad, Gulfam; Al-Ghamdi, Sameer; Alsharif, Mohammed H. Karrar; Elamin, Abubaker Y.; Musthafa, Muhammad; Abbas, Mohammed Y.; Alqarni, Abdulaziz Abdullah; Alqudeebi, Suliman Khaled; Binsaqer, Abdullah Ali; Al-Ghamdi, Hussain

doi:10.1002/jcla.23212

Cited by 13 publications

(19 citation statements)

References 10 publications

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“…Our study showed a correlation between smoking before pregnancy and reduced levels of MCV, MCH and MCHC (indicating the deformation of erythrocytes), although we found no correlation with the level of hemoglobin (Table 3). These results are in line with the findings of Aldosari et al [54], who report the adverse effect of smoking on erythrocyte shape in pregnant women who either smoked or were exposed to passive smoking. A lack of effect of smoking before pregnancy on hemoglobin levels in our study is interesting in the light of findings reported by Van Tiel et al [55], who showed that an improvement in HgB and HCT in people who quit smoking takes as long as 2 years.…”

Section: Resultssupporting

confidence: 93%

Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies

et al. 2023

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Background: Pregnancy significantly increases the demand for iron (Fe) in the female body to facilitate maternal blood volume expansion, placental development, and fetal growth. As Fe flux in pregnancy is significantly influenced by the placenta, the aim of this study was to determine the dependencies between the Fe concentration in the placenta, the infant’s morphometric parameters and the woman’s morphological blood parameters in the last trimester. Methods: The study was conducted on 33 women with multiple (dichorionic–diamniotic) pregnancies from whom the placentas were drawn, and their 66 infants, including pairs of monozygotic (n = 23) and mixed-sex twins (n = 10). Fe concentrations were determined based on inductively coupled plasma atomic emission spectroscopy (ICP-OES) using ICAP 7400 Duo, Thermo Scientific. Results: The results of the analysis showed that lower placental Fe concentrations were associated with deteriorated morphometric parameters of infants, including weight and head circumference. Although we found no statistically significant dependencies between Fe concentration in the placenta and the women’s morphological blood parameters, higher Fe concentration in the placenta of mothers supplemented with Fe correlated with better morphometric parameters in infants compared to those whose mothers received no Fe supplementation. Conclusions: The research adds additional knowledge for placental iron-related processes during multiple pregnancies. However, many limitations of the study do not allow detailed conclusions to be assessed, and statistical data should be assessed conservatively.

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Section: Resultssupporting

confidence: 93%

Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies

et al. 2023

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“…Age, gender, and lifestyle are demographic factors that affect Hematological parameters. Decreasing value of RBC, Hb, PCV and lymphocytes with aging is observed in men (8). However is another study on Canadians except MCHC, most RBC indices levels tended to increase with age in males (9).…”

Section: Discussionmentioning

confidence: 83%

Long term effects of smoking and alcohol consumption on hematological parameters of Indian men: A cross sectional study

Lalit¹,

Kumar

2022

ijhs

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Current study was carried out to cross check the hematological parameters among smokers and alcoholic population from Panipat (Haryana). The hematological examination is playing very important role in assessment during the medical examinations. In the present study reveals that the hematological parameters much important to cross check these parameters in the both the population for public awareness. To make sure if there is any changes in the parameters and if any kind of enhancement in the parameters due to the over consumptions of alcohols and smokers. Material and Methods: The blood samples of the examined population was taken in the EDTA vials by following the standard procedures as mentioned in the guidelines. Total 120 samples have been taken from each group. Samples collected in the EDTA vials for the assessment. The study has been carried out on three different population, Smokers, Alcoholic & Smokers, Controls (Non-alcoholic and Non-Smokers). Results: The present study aims to evaluate the effects of alcohol and smoking on the hematological parameters of a population in the rural area of Panipat (Haryana). Participants with habit of consuming alcohol and smoke who are fulfilling inclusion and exclusion criteria will be considered for their hematological parameters.

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“…Acute, strenuous exercise provided by a low frequency activity can lead to platelet activation, while regular physical activity can decrease/prevent platelet activation and favorably modulate platelet function ( 130 , 150 , 151 ). This could help to explain the findings of lower PCT and PLT among firefighters who exercise weekly ( Supplementary Table S3 ), corroborating the positive correlations that were found between BMI and PLT (S group), MPV (NS group), and PCT (all firefighters) ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…The obtained correlations found for 2-OHFlu (with MON and BAS) and 1-OHPyr (MON, BAS, ALY, and MCV) suggest a possible contribution from cigarette smoke exposure. Smoking is a recognized risk factor for cardiovascular disease development, whose mechanisms are mainly related with inflammation through increased leucocyte count and mutagenic alterations ( 127 , 129 , 151 , 159 , 161 , 162 ). The negative correlations of NEU with 2-OHFlu and EOS with 1-OHPyr only in the NS group suggest that (without tobacco consumption as a variable for increased inflammation) there can be a possible smoking-independent negative impact of the two respective PAHs (fluorene and pyrene) on the first line of immune defense (NEU) and allergenic pathways (EOS).…”

Section: Discussionmentioning

confidence: 99%

Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

Barros,

Paiva,

Oliveira

et al. 2024

Front. Public Health

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IntroductionAvailable literature has found an association between firefighting and pathologic pathways leading to cardiorespiratory diseases, which have been linked with exposure to polycyclic aromatic hydrocarbons (PAHs). PAHs are highlighted as priority pollutants by the European Human Biomonitoring Initiative in occupational and non-occupational contexts.MethodsThis cross-sectional study is the first to simultaneously characterize six creatinine-adjusted PAHs metabolites (OHPAHs) in urine, blood pressure, cardiac frequency, and hemogram parameters among wildland firefighters without occupational exposure to fire emissions (> 7 days), while exploring several variables retrieved via questionnaires.ResultsOverall, baseline levels for total OHPAHs levels were 2 to 23-times superior to the general population, whereas individual metabolites remained below the general population median range (except for 1-hydroxynaphthalene+1-hydroxyacenaphtene). Exposure to gaseous pollutants and/or particulate matter during work-shift was associated with a 3.5-fold increase in total OHPAHs levels. Firefighters who smoke presented 3-times higher total concentration of OHPAHs than non-smokers (p < 0.001); non-smoker females presented 2-fold lower total OHPAHs (p = 0.049) than males. 1-hydroxypyrene was below the recommended occupational biological exposure value (2.5 μg/L), and the metabolite of carcinogenic PAH (benzo(a)pyrene) was not detected. Blood pressure was above 120/80 mmHg in 71% of subjects. Firefighters from the permanent intervention team presented significantly increased systolic pressure than those who performed other functions (p = 0.034). Tobacco consumption was significantly associated with higher basophils (p = 0.01–0.02) and hematocrit (p = 0.03). No association between OHPAHs and blood pressure was found. OHPAHs concentrations were positively correlated with monocyte, basophils, large immune cells, atypical lymphocytes, and mean corpuscular volume, which were stronger among smokers. Nevertheless, inverse associations were observed between fluorene and pyrene metabolites with neutrophils and eosinophils, respectively, in non-smokers. Hemogram was negatively affected by overworking and lower physical activity.ConclusionThis study suggests possible associations between urinary PAHs metabolites and health parameters in firefighters, that should be further assessed in larger groups.

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The influence and impact of smoking on red blood cell morphology and buccal microflora: A case‐control study

Cited by 13 publications

References 10 publications

Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies

Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies

Long term effects of smoking and alcohol consumption on hematological parameters of Indian men: A cross sectional study

Baseline data and associations between urinary biomarkers of polycyclic aromatic hydrocarbons, blood pressure, hemogram, and lifestyle among wildland firefighters

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