The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults

Assmann, Karen E.; Adjibade, Moufidath; Shivappa, Nitin; Hébert, James R.; Wirth, Michael D.; Touvier, Mathilde; Akbaraly, Tasnime; Herçberg, Serge; Galán, Pilar; Julia, Chantal; Kesse‐Guyot, Emmanuelle

doi:10.1093/jn/nxx061

Cited by 18 publications

(12 citation statements)

References 48 publications

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“…The DII has been previously validated with several inflammatory markers such as C-reactive protein, interleukin-6, and homocysteine [28][29][30]. Previous studies have suggested that a high DII, which represents a pro-inflammatory diet, may increase the incidence of age-related chronic diseases and all-cause mortality [7,31].…”

Section: Discussionmentioning

confidence: 99%

Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

2020

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Background: Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Methods: 73 middle-aged sedentary adults (40–65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: a weak positive association was observed between DII and S-Klotho plasma levels (β = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057). Conclusions: A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults.

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Section: Discussionmentioning

confidence: 99%

Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

2020

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“…Some neurodevelopmental abnormalities including autism spectrum disorders (ASD) and cognitive impairment have been linked to early life immune activation and inflammation [231]. The DII has been associated with cognitive disorders such as Parkinson’s disease [238,239] as well as normal cognitive decline in aging populations [238,239,240,241,242,243], but there is still a lack of research in relation to child neurodevelopment.…”

Section: DII and Neurodevelopmentmentioning

confidence: 99%

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

et al. 2019

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There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children’s DII (C-DII) scores and new avenues of investigation in this field of nutritional research.

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“…Alpha-tocopherol is the most active form of vitamin E and has been shown to be cardioprotective in numerous cell culture, animal model and human studies [34][35][36]. Daily supplementation with antioxidant vitamins (ascorbic acid and α-tocopherol) may help prevent myocardial infarctions [37] and increase the probability of healthy aging [38]. Some studies suggest that low concentration of vitamin E was significantly associated with CAS [39].…”

Section: Discussionmentioning

confidence: 99%

Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

Liu¹,

Liu²,

Chen³

et al. 2020

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Background: The beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) and tocopherols remain controversial. This study was conducted to examine the plasma levels of different analogues of omega-3 PUFAs and tocopherols, and to evaluate their relationships with aging-related diseases. Methods: 136 consecutive men with the median age of 70 (ranging from 50 to 97) years old were recruited. Plasma eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-, γ-, and δ-tocopherol were measured by liquid chromatography mass spectrometry. Results: Plasma omega-3 PUFAs were positively correlated with α- and γ-tocopherol (p<0.01), while the relationships between omega-3 PUFAs and δ-tocopherol were not significant (p>0.05). Increasing age was the most profound risk factor for coronary artery disease (CAD), carotid atherosclerosis (CAS), hypertension and these comorbidities (p<0.01). Age had positive associations with certain atherosclerotic parameters, including carotid intima-media thickness (p=0.046), carotid artery plague area (p<0.001) and brachial-ankle pulse wave velocity (p<0.001). In these observed isoforms, only γ-tocopherol had a mild inverse correlation with age (p=0.002). High plasma α-tocopherol concentration served as a potential protective factor for CAD (odds ratio [OR] 0.65; 95% CI 0.48-0.89; p=0.006), and was inversely associated with maximum systolic internal carotid artery (ICA) velocity (p=0.011). Plasma DHA concentration was negatively associated with carotid artery plague area (p=0.028) and ICA velocity (p=0.006), while its correlations with atherosclerosis diseases, including CAD and CAS, were not significant (p>0.05). Conclusions: Age is positively correlated with atherosclerosis, hypertension and comorbidities. Alpha-tocopherol may be a protective factor for atherosclerosis, while the correlations between omega-3 PUFAs and atherosclerosis were not significant.

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The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults

Abstract: This study suggests that a proinflammatory diet may lower the probability of overall HA. The SU.VI.MAX trial was registered at www.clinicaltrials.gov as NCT00272428.

Cited by 18 publications

References 48 publications

Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review

Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

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