The inflammation theory of disease

Hunter, Philip

doi:10.1038/embor.2012.142

Cited by 249 publications

(135 citation statements)

References 11 publications

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“…Future studies will be needed to determine the biological significance of this interaction. However, these data raise the possibility of a MyD88-mediated negative feedback loop that ensures that innate immunity is self limiting (Figure 7); this could be relevant to sepsis, cancer, and the myriad of other diseases with an inflammatory component [84].…”

Section: Discussionmentioning

confidence: 99%

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

2013

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Controlling infectious disease without inducing unwanted inflammatory disease requires proper regulation of the innate immune response. Thus, innate immunity needs to be activated when needed during an infection, but must be limited to prevent damage. To accomplish this, negative regulators of innate immunity limit the response. Here we investigate one such negative regulator encoded by an alternative splice form of MyD88. MyD88 mRNA exists in two alternative splice forms: MyD88L, a long form that encodes a protein that activates innate immunity by transducing Toll-like receptor (TLR) signals; and a short form that encodes a different protein, MyD88S, that inhibits the response. We find that MyD88S levels regulate the extent of inflammatory cytokine production in murine macrophages. MyD88S mRNA levels are regulated by the SF3A and SF3B mRNA splicing complexes, and these mRNA splicing complexes function with TLR signaling to regulate MyD88S production. Thus, the SF3A mRNA splicing complex controls production of a negative regulator of TLR signaling that limits the extent of innate immune activation.

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Section: Discussionmentioning

confidence: 99%

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

2013

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“…Pada pasien ini tidak ada keluarga dengan keluhan yang serupa, namun bisa saja hal ini sesungguhnya tidak terperhatikan mengingat bahwa tumor ini jinak, dan jika berukuran kecil, dapat tumbuh tanpa gejala. 1,4,8,11,12,13 Pada pasien ini dilakukan tindakan timpanomastoidektomi dinding utuh. Saat operasi tumor ditemukan di telinga tengah bersamaan dengan jaringan granulasi dan saat itu dibersihkan seluruhnya.…”

Section: Pembahasanunclassified

Neurofibroma Telinga Tengah dengan Otitis Media Supuratif Kronis

Pramita¹,

Munilson²,

Edward³

2018

JKA

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AbstrakPendahuluan: Neurofibroma adalah tumor saraf yang cukup sering dijumpai, tetapi hanya beberapa kasus yang melibatkan telinga tengah yang pernah dilaporkan. Kasus: Dilaporkan seorang perempuan berusia 51 tahun dengan keluhan telinga kiri berair, hilang timbul sejak 30 tahun yang lalu. Pasien dilakukan tindakan timpanomastoidektomi dinding utuh telinga kiri, intraoperatif ditemukan jaringan granulasi beserta jaringan berpapilpapil di liang telinga. Hasil patologi anatomi adalah neurofibroma dengan kalsifikasi. Kesimpulan: Neurofibroma merupakan suatu tumor yang dapat muncul dimana saja di tubuh. Adanya neurofibroma bersamaan dengan OMSK diduga akibat peranan inflamasi yang mencetuskan timbulnya tumor. Tatalaksana dan follow up yang baik dapat memberikan hasil yang memuaskan. AbstractIntroduction: Neurofibroma are nerve tumors that relatively common, but only a few cases involving the middle ear have been reported. Case Report: Reported a 51 -year -old woman, with chief complain discharge coming out from her left ear since 30 years ago intermittently. We performend tympanomastoidectomy canal wall up to her, intraoperatif we found that granulation tissue with some papilomatous tissue. The results of anatomic pathology was neurofibroma with calcification. Conclusion: Neurofibroma is a tumor that can arise anywhere. We suggest there was a role of inflammation that casuse this neurofibroma accompanied with chronic suppurative otitis media A good treatment can bring a satisfactory result to this case.

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“…Inflammation has been implicated as a causative factor in nearly all chronic diseases. 22 From an evolutionary perspective, the body's inflammatory response was vital for survival before modern sanitation processes (water purification, sewage systems, and the recognition of hygiene issues such as hand washing). Today, we live longer, and thus inflammatory responses are more likely to confuse and overwhelm the body's defense systems.…”

Section: Inflammationmentioning

confidence: 99%

“…120 It is increasingly recognized that the real issue in health care-lifestyleshould become the primary prescription for the leading causes of disease that result in the highest rates of mortality. [4][5][6][7]9,22 The slow progress in decreasing mortality rates from CVD incriminates an unhealthy diet and a sedentary lifestyle as major contributing factors. 121 Ample evidence exists to support the avocation of a diet on the basis of the recommendations outlined in Table 1.…”

Section: Original Research and Contributionsmentioning

confidence: 99%

Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival

Bodai¹,

Nakata²,

Wong

et al. 2018

TPJ

149

106

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By ignoring the root causes of disease and neglecting to prioritize lifestyle measures for prevention, the medical community is placing people at harm. Advanced nations, influenced by a Western lifestyle, are in the midst of a health crisis, resulting largely from poor lifestyle choices. Epidemiologic, ecologic, and interventional studies have repeatedly indicated that most chronic illnesses, including cardiovascular disease, cancer, and type 2 diabetes, are the result of lifestyles fueled by poor nutrition and physical inactivity.In this article, we describe the practice of lifestyle medicine and its powerful effect on these modern instigators of premature disability and death. We address the economic benefits of prevention-based lifestyle medicine and its effect on our health care system: A system on the verge of bankruptcy. We recommend vital changes to a disastrous course. Many deaths and many causes of pain, suffering, and disability could be circumvented if the medical community could effectively implement and share the power of healthy lifestyle choices. We believe that lifestyle medicine should become the primary approach to the management of chronic conditions and, more importantly, their prevention. For future generations, for our own health, and for the Hippocratic Oath we swore to uphold ("First do no harm"), the medical community must take action. It is our hope that the information presented will inspire our colleagues to pursue lifestyle medicine research and incorporate such practices into their daily care of patients. The time to make this change is now.

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The inflammation theory of disease

Abstract: An increasing body of evidence shows that chronic inflammation causes and advances many common diseases. This opens new possibilities for treatment and therapy by blocking the inflammatory processes.

Cited by 249 publications

References 11 publications

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

Neurofibroma Telinga Tengah dengan Otitis Media Supuratif Kronis

Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival

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