The inferior parathyroid glands preserved in site recover faster than the superior parathyroid glands preserved in site after thyroid surgery for carcinoma

Wang, Bin; Zhu, Chunhua; Liu, Hong; Yao, Xiaoxi; Wu, Jian

doi:10.1097/md.0000000000020886

Cited by 1 publication

(1 citation statement)

References 34 publications

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“…Several studies have shown that the incidence of hypocalcemia was reduced with preservation of at least one parathyroid gland with intact blood supply (8). Some scholars have suggested that the functional recovery of superior and inferior parathyroids preserved in situ is different (9). In addition, some scholars have indicated that parathyroid autotransplantation is another effective strategy to preserve parathyroid function (10).…”

Section: Introductionmentioning

confidence: 99%

Relationship between the extent of central node dissection and parathyroid function preservation in thyroid cancer surgery

Sun¹,

Sheng²,

Zhou³

et al. 2021

Gland Surg

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Background: The risk and effect of hypocalcemia following surgery of different magnitudes remains unclear. Thus, we assessed whether different extents of central lymph node dissection (CLND) and status of preserved parathyroid glands can influence parathyroid function in differentiated thyroid carcinoma (DTC) patients with initial surgical resection.Methods: Participants were categorized into 6 groups based on the extent of the surgical procedures, number of parathyroid glands preserved in situ, and parathyroid autotransplantation. The frequencies of hypocalcemia, serum calcium (Ca) levels, and parathyroid hormone (PTH) levels among the different groups were analyzed.Results: The prevalence of hypocalcemia, number and status of parathyroid glands preserved in situ, and parathyroid autotransplantation were inversely related to extensive CLND (r=−0.18; P<0.05). The decrease of serum Ca and PTH was most severe on postoperative days (POD) 1-7. The incidence of hypocalcemia was higher in Group C than in Group B and A (P<0.05). The average postoperative serum Ca and PTH levels in Group C were significantly lower than group A on POD 1-7 (P<0.05). The incidence of hypocalcemia was obviously increased in Group D compared to Groups E and F (P<0.05). The mean serum Ca and PTH levels in Group D were significantly lower than in Group F (P<0.05), and the same results could be observed between Groups D and E (P<0.05). However, through parathyroid autotransplantation, there was no significant difference that could be found between Groups E and F on POD 1-7 (P>0.05).Conclusions: With the expansion of CLND scope, postoperative parathyroid function will be affected, increasing the risk of postoperative hypocalcemia. When at least 1-2 parathyroid glands were reserved in situ plus at least 1 parathyroid gland autotransplantation, there was little effect on postoperative parathyroid function.

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Section: Introductionmentioning

confidence: 99%