The inferior colliculus of the rat: A quantitative analysis of monaural frequency response areas

Hernández, Ó.; Espinosa, Nelson; Pérez-González, David; Malmierca, Manuel S.

doi:10.1016/j.neuroscience.2005.01.001

Cited by 74 publications

(91 citation statements)

References 55 publications

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“…First, although our responses were sampled throughout the rostrocaudal extent of the TLC, no tonotopic organization was evident; this observation clearly contrasts with the well known tonotopic map of the IC (Kelly et al, 1991). Moreover, tuning curves and frequency response areas were in general somewhat wider in the TLC than in the IC (Kelly et al, 1991;Hernández et al, 2005), which indicates that TLC neurons are less selective to sound frequency. This is particularly true for neurons sensitive to high frequency sounds, whose outstanding frequency selectivity in the IC (Kelly et al, 1991;Hernández et al, 2005) was not matched by the corresponding neurons in the TLC.…”

Section: The Tlc Is Electrophysiologically Distinctmentioning

confidence: 64%

“…Moreover, tuning curves and frequency response areas were in general somewhat wider in the TLC than in the IC (Kelly et al, 1991;Hernández et al, 2005), which indicates that TLC neurons are less selective to sound frequency. This is particularly true for neurons sensitive to high frequency sounds, whose outstanding frequency selectivity in the IC (Kelly et al, 1991;Hernández et al, 2005) was not matched by the corresponding neurons in the TLC. Furthermore, sustained responses were more common in the TLC than in the IC.…”

Section: The Tlc Is Electrophysiologically Distinctmentioning

confidence: 92%

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The TLC: A Novel Auditory Nucleus of the Mammalian Brain

Saldaña¹,

Viñuela²,

Marshall³

et al. 2007

J. Neurosci.

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We have identified a novel nucleus of the mammalian brain and termed it the tectal longitudinal column (TLC). Basic histologic stains, tract-tracing techniques and three-dimensional reconstructions reveal that the rat TLC is a narrow, elongated structure spanning the midbrain tectum longitudinally. This paired nucleus is located close to the midline, immediately dorsal to the periaqueductal gray matter. It occupies what has traditionally been considered the most medial region of the deep superior colliculus and the most medial region of the inferior colliculus. The TLC differs from the neighboring nuclei of the superior and inferior colliculi and the periaqueductal gray by its distinct connections and cytoarchitecture. Extracellular electrophysiological recordings show that TLC neurons respond to auditory stimuli with physiologic properties that differ from those of neurons in the inferior or superior colliculi. We have identified the TLC in rodents, lagomorphs, carnivores, nonhuman primates, and humans, which indicates that the nucleus is conserved across mammals. The discovery of the TLC reveals an unexpected level of longitudinal organization in the mammalian tectum and raises questions as to the participation of this mesencephalic region in essential, yet completely unexplored, aspects of multisensory and/or sensorimotor integration.

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Section: The Tlc Is Electrophysiologically Distinctmentioning

confidence: 64%

Section: The Tlc Is Electrophysiologically Distinctmentioning

confidence: 92%

The TLC: A Novel Auditory Nucleus of the Mammalian Brain

Saldaña¹,

Viñuela²,

Marshall³

et al. 2007

J. Neurosci.

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“…Extracellular single-unit or multiunit activity was recorded from the IC in 137 pigmented rats (Rattus norvergicus, Rj:Long-Evans; body weight, 109 -420 g) of both sexes. The methods have been described in previous studies (Hernández et al, 2005;Pérez-González et al, 2005, so only the essential details are given here. Animals were anesthetized with urethane (1.5 g/kg, 20% solution, i.p.…”

Section: Methodsmentioning

confidence: 99%

“…The animal was placed inside a double-walled sound attenuation room. A local anesthetic (lidocaine) was applied to the ears, and the rat's head was immobilized and placed in a stereotaxic frame with the ear bars replaced by hollow specula that accommodated a sound delivery system (Rees et al, 1997;Hernández et al, 2005). The animal's body temperature was monitored with a rectal probe and maintained at 38°C by a thermostatically controlled electric blanket.…”

Section: Methodsmentioning

confidence: 99%

“…A total of 604 FRAs were obtained from 125 rats. Some (n ϭ 400) of the units were used for other studies (n ϭ 237 from Hernández et al, 2005; n ϭ 163 from Pérez-González et al, 2005. Of the 604, 237 units were recorded from 67 rats in a laboratory where stimuli were generated with a waveform generator (8904A multifunction synthesizer; Hewlett Packard, Palo Alto, CA) controlled by a computer (Hernández et al, 2005).…”

Section: Methodsmentioning

confidence: 99%

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A Discontinuous Tonotopic Organization in the Inferior Colliculus of the Rat

et al. 2008

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Audible frequencies of sound are encoded in a continuous manner along the length of the cochlea, and frequency is transmitted to the brain as a representation of place on the basilar membrane. The resulting tonotopic map has been assumed to be a continuous smooth progression from low to high frequency throughout the central auditory system. Here, physiological and anatomical data show that best frequency is represented in a discontinuous manner in the inferior colliculus, the major auditory structure of the midbrain. Multiunit maps demonstrate a distinct stepwise organization in the order of best frequency progression. Furthermore, independent data from single neurons show that best frequencies at octave intervals of approximately one-third are more prevalent than others. These data suggest that, in the inferior colliculus, there is a defined space of tissue devoted to a given frequency, and input within this frequency band may be pooled for higher-level processing.

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Organization of the inferior colliculus of the gerbil (Meriones unguiculatus): Differences in distribution of projections from the cochlear nuclei and the superior olivary complex

2006

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The inferior colliculus (IC) receives its major ascending input from the cochlear nuclei, the superior olivary complex and the nuclei of the lateral lemniscus. In order to better understand the terminal distribution of the inputs from these sources relative to one another, we made focal injections of a retrograde tracer, biotinylated dextran amine, in different parts of the IC in 74 gerbils (Meriones unguiculatus). Based on counts of labeled cells in brainstem auditory nuclei, the cases could be divided into three groups. Group 1 cases had labeled cells in both the cochlear nuclei and in the lateral and medial superior olivary nuclei. Group 2 cases had labeled cells in the cochlear nuclei but few or none in the lateral and medial superior olivary nuclei. Both groups had labeled cells in the nuclei of the lateral lemniscus and the superior paraolivary nucleus. Group 3 cases had few labeled cells in any of the ascending auditory pathways. The group to which a case belonged was strongly related to the location of the injection site in the IC. The injection sites for both Groups 1 and 2 were located in the central nucleus, but those for Group 1 tended to be located laterally relative to those for Group 2, which were located more medially and caudally. The injection sites for Group 3 cases lay outside the central nucleus of the IC. The two regions of the central nucleus of the IC, distinguished on the basis of connectivity, are likely to subserve different functions.Keywords auditory system; biotinylated dextran amine; cytochrome oxidase; neuroanatomy; nuclei of the lateral lemniscus

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The inferior colliculus of the rat: A quantitative analysis of monaural frequency response areas

Cited by 74 publications

References 55 publications

The TLC: A Novel Auditory Nucleus of the Mammalian Brain

The TLC: A Novel Auditory Nucleus of the Mammalian Brain

A Discontinuous Tonotopic Organization in the Inferior Colliculus of the Rat

Organization of the inferior colliculus of the gerbil (Meriones unguiculatus): Differences in distribution of projections from the cochlear nuclei and the superior olivary complex

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