The infectious etiology of the antiphospholipid syndrome: links between infection and autoimmunity

Harel, Michal; Aron-Maor, Anabel; Sherer, Yaniv; Blank, Miri; Shoenfeld, Yehuda

doi:10.1016/j.imbio.2005.10.004

Cited by 50 publications

(43 citation statements)

References 36 publications

(57 reference statements)

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“…2). Selection of the serum to be used as the hantavirus antibody source was not a minor issue, as circulating ApoH antibodies have been identified in the sera of patients with different infectious conditions (6,9,13,16,20,55). Based on these observations, we next sought to challenge our findings by using monoclonal antibodies developed against the ANDV Gc glycoprotein, a protein found at the surface of the viral particle.…”

Section: Resultsmentioning

confidence: 99%

Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome

Godoy

Marsac

Stefas³

et al. 2009

J Virol

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Hantavirus cardiopulmonary syndrome (HCPS) is a highly pathogenic emerging disease (40% case fatality rate) caused by New World hantaviruses. Hantavirus infections are transmitted to humans mainly by inhalation of virus-contaminated aerosol particles of rodent excreta and secretions. At present, there are no antiviral drugs or immunotherapeutic agents available for the treatment of hantaviral infection, and the survival rates for infected patients hinge largely on early virus recognition and hospital admission and aggressive pulmonary and hemodynamic support. In this study, we show that Andes virus (ANDV) interacts with human apolipoprotein H (ApoH) and that ApoH-coated magnetic beads or ApoH-coated enzyme-linked immunosorbent assay plates can be used to capture and concentrate the virus from complex biological mixtures, such as serum and urine, allowing it to be detected by both immunological and molecular approaches. In addition, we report that ANDV-antigens and infectious virus are shed in urine of HCPS patients.

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Section: Resultsmentioning

confidence: 99%

Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome

Godoy

Marsac

Stefas³

et al. 2009

J Virol

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“…Lipid disturbances consequent on antiretroviral treatment in AIDS may be prime causes of these complications. Other viral infections, including Epstein-Barr virus, varicella, cytomegalovirus, rubella virus were reported [2,8]. However, in these cases, propensity for IgM-aPL is usually shown with low titer and presence of aPL is often transient and disappears after the treatment of the infection [1,8].…”

Section: Case Reportmentioning

confidence: 99%

“…Recently, the infectious origin of APS was proven to be one of the explanations for the generation of anti-beta-2-glycoprotien I (β2GPI) antibodies by sharing molecular mimicry with common bacteria [2,[8][9][10][11]. The human β2GPI molecule, a plasma protein, has anticoagulant properties in vitro which are inhibition of prothrombinase activity, ADP-induced platelet aggregation, and platelet factor IX production [8].…”

Section: Case Reportmentioning

confidence: 99%

“…Also hematological malignancies and other hypercoagulable states are rarely related with portal vein thrombosis and portal hypertension. Antiphospholipid syndrome (APS) is a clinical syndrome consists of the presence of antiphospholipid antibodies (aPL) and a status of hypercoagulability [1,2]. Intravascular thrombosis can arise in vessels of any size in any organ.…”

Section: Introductionmentioning

confidence: 99%

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Antiphospholipid Syndrome Presenting Variceal Bleeding in Patient with Systemic Anaerobic Bacterial Infection

et al. 2013

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“…Antiphospholipid antibody is the only autoantibody that induces blood into hypercoagulability state, just like one bridge between two physiology systems, immunity and coagulation, which may cause formulation of arterial and venous thrombosis with unknown reasons [11][12][13][14][15] . b2GPⅠ is known as a target antigen of antiphospholipid antibody [16][17][18][19] . Although ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with unknown reasons, it is closely related to immunity, thrombosis formulation and blood hypercoagulability state [20][21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Relationship and significance between anti-beta2-glycoprotein I antibodies and platelet activation state in patients with ulcerative colitis

Gao

Gao²,

Wang³

et al. 2008

WJG

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AIM:To study the relationship between anti-b2-glycoprotein Ⅰ (ab2GPⅠ) antibodies and platelet activation state in patients with ulcerative colitis (UC) and its significance. METHODS:Peripheral blood samples were collected from 56 UC patients (34 males and 22 females, aged 43.5 years, range 21-66 years), including 36 at active stage and 20 at remission stage, and 25 sex-and agematched controls. The level of ab2GPⅠ was measured by ELISA. The platelet activation markers, platelet activation complex-Ⅰ (PAC-Ⅰ) and P-selectin (CD62P) were detected by flow cytometry. RESULTS:The A value for IgG ab2GPⅠ in the active UC group was 0.61 ± 0.13, significantly higher than that in the remittent UC and control groups (0.50 ± 0.13 and 0.22 ± 0.14, P < 0.01). There was a significant difference between the two groups (P < 0.01). The A value for IgM ab2GPⅠ in the active and remittent UC groups was 0.43 ± 0.13 and 0.38 ± 0.12, significantly higher than that in the control group (0.20 ± 0.12, P < 0.01). However, there was no significant difference between the two groups (P > 0.05). The PAC-Ⅰ positive rate for the active and remittent UC groups was 30.6% ± 7.6% and 19.6% ± 7.8% respectively, significantly higher than that for the control group (6.3% ± 1.7%, P < 0.01). There was a significant difference between the two groups (P < 0.01). The CD62P positive rate for the active and remittent UC groups was 45.0% ± 8.8% and 31.9% ± 7.8% respectively, significantly higher than that for the control group (9.2% ± 2.7%, P < 0.01). There was a significant difference between the two groups (P < 0.01). In the active UC group, the more severe the state of illness was, the higher the A value for IgG ab2GPⅠ was, and the positive rate for PAC-I and CD62P was positively correlated with the state of illness (Fab2GPⅠ = 3.679, P < 0.05; FPAC-I (%) = 5.346, P < 0.01; and FCD62P (%) = 5. 418, P < 0.01). Meanwhile, in the same state of illness, the A value for IgG ab2GPⅠ was positively correlated to the positive rates for PAC-I and CD62P.CONCLUSION: ab2GPⅠ level, platelet activation state and their relationship of them are closely correlated with the pathogenesis and development of UC.

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The infectious etiology of the antiphospholipid syndrome: links between infection and autoimmunity

Cited by 50 publications

References 36 publications

Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome

Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome

Antiphospholipid Syndrome Presenting Variceal Bleeding in Patient with Systemic Anaerobic Bacterial Infection

Relationship and significance between anti-beta2-glycoprotein I antibodies and platelet activation state in patients with ulcerative colitis

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