1960
DOI: 10.1016/0003-9969(60)90091-1
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The infectious and transmissible nature of experimental dental caries

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Cited by 389 publications
(192 citation statements)
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“…These micro-organisms harbor themselves onto tooth structure in form of bio-film, thus leading of formation of the dental plaque [1]. WHO defined dental plaque as a specific but highly variable structural entity, resulting from sequential colonization of microorganisms on tooth surfaces, restorations & other parts of oral cavity, composed of salivary components like mucin, desquamated epithelial cells, debris & microorganisms, all embedded in extracellular gelatinous matrix [2].…”
Section: Introductionmentioning
confidence: 99%
“…These micro-organisms harbor themselves onto tooth structure in form of bio-film, thus leading of formation of the dental plaque [1]. WHO defined dental plaque as a specific but highly variable structural entity, resulting from sequential colonization of microorganisms on tooth surfaces, restorations & other parts of oral cavity, composed of salivary components like mucin, desquamated epithelial cells, debris & microorganisms, all embedded in extracellular gelatinous matrix [2].…”
Section: Introductionmentioning
confidence: 99%
“…1 This view of the disease was the basis for the proposal of many preventive philosophies still in use nowadays, based on the treatment of the disease itself, and not of the sequelae of the disease (the cavities). Although the concepts brought up by pioneer studies on the multiple factors involved in caries disease changed the paradigm of caries and moved Dentistry to a higher level of quality in patient care, in order to understand how fluoride could interfere with the caries disease, we must leave the prominent "Keyes diagram" behind and move forward to a deeper understanding of the biological and social factors involved in the disease.…”
mentioning
confidence: 99%
“…Classical studies have elegantly demonstrated that caries is not only a bacterial infection but also a transmissible disease [45][46][47][48]. Although caries has a primary bacterial etiology, it is a multifactorial disease, and important modulating factors, including diet, host (teeth, saliva, mucosal immunity), social-economic conditions, and time, play a role in the initiation and progression of the disease [49].…”
Section: Cariogenic Biofilmmentioning
confidence: 99%