The inductive properties of epithelial established cell lines

A potential role for tetranectin in mineralization during osteogenesis.

“…Much less bone and cartilage were located in the more central part of the tumor. This morphologic pattern was as described previously for some epithelial cell lines inducing bone formation when injected into nude mice (1,43). By morphological examination tumors produced by PC12-tet cells appeared to contain significantly more bone material than those produced by the untransfected PC12 cells or by PC12-control cells, by several parameters that were quantitated by Mocha Image Analysis Software and LSM laserscan microscopy (Table I).…”

Expression of bone morphogenetic proteins in salivary pleomorphic adenomas

“…Others have also demonstrated that transplantation of several epithelial tumour cell lines leads to ectopic cartilage and bone formation [30,33]. These observations suggest that epithelial cells synthesize BMPs or BMP-like molecules which induce undifferential mesenchymal cells to differentiate into chondrocytes and osteoblasts.…”

Initiation and enhancement of bone formation: A review

“…Huggins (1930Huggins ( , 1931 demonstrated bone induction in classical experiments more than 50 years ago by transplantation of living transitional urinary epithelium into various connective tissues of dogs and rabbits. Subsequently, other living epithelial cells were found to have similar properties (Anderson 1976, Wlodarski 1969. A significant physiologic finding was that normal mouse bone synthesized and secreted a bone-inducing factor (Goldhaber 1961); later studies revealed a similar material in certain mouse and human osteosarcomas (Hanamura et al 1980, Amitani and Nakata 1974, Heiple et al 1968, Bauer and Urist 1981.…”