The induction of rat bladder cancer by 2-naphthylamine

Hicks, Rodney W.; Wright, Reba K.; Wakefield, J. St. J.

doi:10.1038/bjc.1982.250

Cited by 27 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, the rat has for many years been considered resistant to the bladder carcinogen 2-naphthylamine (6). But Hicks and her colleagues (7) showed that using test conditions that favored the production of the active metabolite (i.e., high doses given at less frequent intervals rather than low doses given continuously), 2-naphthylamine is an effective rat bladder carcinogen. Overall, metabolism per se has not been shown to be a key factor in identifying agents active in animals but inactive in humans.…”

Section: Nonrelevant Animal Carcinogensmentioning

confidence: 99%

Needs for biological risk assessment in interspecies extrapolation.

Clayson

1988

Environ Health Perspect

View full text Add to dashboard Cite

This paper suggests that not all chemicals shown to be carcinogenic in animals may exert this effect in humans exposed to much lower amounts of the chemical. It is possible that agents which differ in their effects in humans and animals may be identified through the application of Biological Risk Assessment to the experimental results. Chemicals tested in systems in which untreated animals develop high background yields of tumors or in which high-dose toxicity may be a critical factor in the induction of carcinogenesis are suggested as candidates requiring very careful consideration before their carcinogenicity in humans is assumed.

show abstract

Section: Nonrelevant Animal Carcinogensmentioning

confidence: 99%

Needs for biological risk assessment in interspecies extrapolation.

Clayson

1988

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…Some of these compounds are able to induce tumours, particularly in the urinary bladder of humans and animals 1,2) . Among them, benzidine, 2-naphthylamine, and 4-amino-biphenyl, are the most important carcinogenic substances which are also present in tobacco smoke.…”

mentioning

confidence: 99%

Urinary Mutagenicity, CYP1A2 and NAT2 Activity in Textile Industry Workers

Fanlo¹,

Sinués²,

Mayayo³

et al. 2004

Journal of Occupational Health

View full text Add to dashboard Cite

Urinary Mutagenicity, CYP1A2 and NAT2 Activity in Textile Industry Workers: Ana FANLO, et al. Department of Pharmacology and Physiology, University of Zaragoza, Spain-The two major causes of bladder cancer have been recognised to be cigarette smoke and occupational exposure to arylamines. These compounds are present both in tobacco smoke and in the dyes used in textile production. Aromatic amines suffer oxidative metabolism via P450 cytochrome CYP1A2, and detoxification by the polymorphic NAT2. The aim of the present work was to assess the association between occupational-derived exposure to mutagens and CYP1A2 or NAT2 activity. This cross-sectional study included 117 textile workers exposed to dyes and 117 healthy controls. The urinary mutagenicity was determined in 24 h urine using TA98 Salmonella typhimurium strain with microsomal activation S9 (MIS9) or incubation with β-glucuronidase (MIβ). Urinary caffeine metabolite ratios: AFMU+1X+1U/17U, and AFMU/AFMU+1X+1U were calculated to assess CYP1A2 and NAT2 activities, respectively. The results show that workers present a strikingly higher urine mutagenicity than controls (p<0.0001), despite the implementation of the new restrictive norms forbidding the industrial use of the most carcinogenic arylamines. Neither NAT2 nor CYP1A2 activity had any effect on the markers of internal exposure to mutagens, since no significant differences were observed when the urinary mutagenicity of slow and fast acetylators (p>0.05) was compared, and the urinary mutagenicity was not significantly associated with the CYP1A2 activity marker (r=0.04 and r=-0.01 for MIS9 and MIβ, respectively). This study clearly indicates the need for further protective policies to minimise exposure to the Received May 10, 2004; Accepted Sep 6, 2004 Correspondence to: B. Sinués, Department of Pharmacology, Medicine School, University of Zaragoza, Domingo Miral s/n, 50009 Zaragoza, Spain (e-mail: bsinues@posta.unizar.es) lowest feasible limit in order to avoid unnecessary risks.

show abstract

“…Wistar rats (20 females) were exposed to 2-NA at a dose of 300 mg/kg b.w. once a week for 57 weeks via gavage (in arachis oil) [101], with 20 rats serving as the control group. One moribund animal was killed.…”

Section: Oral Administrationmentioning

confidence: 99%

2-naphthylamine toxicity

Czubacka

Czerczak

2020

Med Pr

View full text Add to dashboard Cite

In the past, 2-naphthylamine (2-NA) was used for the production of azo dyes, as an antioxidant in the cable industry and in the rubber industry. Despite the fact that 2-NA is not produced on an industrial scale, it is still used in small quantities as a model bladder carcinogen in laboratories, and also for sewage control, water analysis and oxytocinase assays. In addition, it is detected in the air in coke ovens, where it is formed as one of the pyrolysis products. The main aim of this work is to provide an actual literature review for health risk assessments related to 2-NA which is still used in laboratories. Occupational exposure to 2-NA is important for the respiratory tract, mucous membranes and the skin, and, to a lesser extent, for absorption from the gastrointestinal tract. It is absorbed into the body through the skin and by inhalation, and then undergoes metabolic changes. Most of the absorbed 2-NA dose is excreted in the urine, in the form of metabolites, metabolites conjugated to acids, and even in an unchanged form. Based on literature data, the effects of 2-NA toxicity in sub-chronic and chronic exposure include contact dermatitis, chronic cystitis and bladder cancer. The authors have concluded that it is recommended to determine the occupational exposure limit which will allow preparing the exposure assessment of people at work.

show abstract

The induction of rat bladder cancer by 2-naphthylamine

Cited by 27 publications

References 24 publications

Needs for biological risk assessment in interspecies extrapolation.

Needs for biological risk assessment in interspecies extrapolation.

Urinary Mutagenicity, CYP1A2 and NAT2 Activity in Textile Industry Workers

2-naphthylamine toxicity

Contact Info

Product

Resources

About