“…However, owing to the inherent nature of the segmented RNA virus to mutate and undergo reassortment, the danger of HPAI viruses gaining the ability to efficiently transmit horizontally between humans, like that of seasonal influenza A virus strains, while retaining high virulence cannot be ignored (5). A commonly cited complication of influenza virus infections in humans is the rapid development of a hyperacute dysregulation of proinflammatory cytokines and chemokines, described as hypercytokinemia or a cytokine storm, which is a self-destructive and often fatal syndrome despite supportive medical interventions (41)(42)(43). Prevention by vaccination and treatment by antineuraminidase drugs are the mainstays of influenza management, but they are not without major shortcomings, namely, a long lead vaccine production time and the development of drug resistance (11,13,23).…”