The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

Geller, Anne E; Shrestha, Rejeena; Woeste, Matthew R; Guo, Haixun; Hu, Xiaoling; Ding, Chuan‐Fan; Andreeva, Kalina; Chariker, Julia H.; Zhou, Meijun; Tieri, David; Watson, Corey T.; Mitchell, Robert A.; Zhang, Huang‐Ge; Li, Yan; Martin, Robert C.G.; Rouchka, Eric C.; Yan, Jun

doi:10.1038/s41467-022-28407-4

Cited by 41 publications

(54 citation statements)

References 84 publications

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“… 106 In addition, β‐glucan treatment induced a CCR2‐dependent influx of monocytes to the pancreas that display trained immunity profile, and β‐glucan‐treated mice showed reduced tumor burden and prolonged survival in orthotopic models of pancreatic cancer. 107 …”

Section: The Yin‐yang Balance Of Trained Immunitymentioning

confidence: 99%

“…The research may have broader implications for cancer therapy since a 60‐year follow‐up retrospective clinical trial showed that childhood BCG vaccination was associated with a lower risk of lung cancer development in the United States 106 . In addition, β‐glucan treatment induced a CCR2‐dependent influx of monocytes to the pancreas that display trained immunity profile, and β‐glucan‐treated mice showed reduced tumor burden and prolonged survival in orthotopic models of pancreatic cancer 107 …”

Section: The Yin‐yang Balance Of Trained Immunitymentioning

confidence: 99%

“…106 In addition, β-glucan treatment induced a CCR2-dependent influx of monocytes to the pancreas that display trained immunity profile, and β-glucan-treated mice showed reduced tumor burden and prolonged survival in orthotopic models of pancreatic cancer. 107 To sum up, optimal induction of trained immunity can lead to enhanced protection against infections and cancer. Through further research, novel therapeutic targets may become available to harness trained immunity to improve immune responses to vaccines and resistance to infections.…”

Section: The Amicable (Yang) Effects Of Trained Immunitymentioning

confidence: 99%

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Trained immunity: A Yin‐Yang balance

Lowrie

et al. 2022

MedComm

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Traditionally, immune memory is regarded as an exclusive hallmark of adaptive immunity. However, a growing body of evidence suggesting that innate immune cells show adaptive characteristics has challenged this dogma. In the past decade, trained immunity, a de facto innate immune memory, has been defined as a long‐term functional reprogramming of cells of the innate immune system: the reprogramming is evoked by endogenous or exogenous insults, the cells return to a nonactivated state and subsequently show altered inflammatory responses against a second challenge. Trained immunity became regarded as a mechanism selected in evolution to protect against infection; however, a maladaptive effect might result in hyperinflammation. This dual effect is consistent with the Yin‐Yang theory in traditional Chinese philosophy, in which Yang represents active, positive, and aggressive factors, whereas Yin represents passive, negative, and inhibitory factors. In this review, we give a brief overview of history and latest progress about trained immunity, including experimental models, inductors, molecular mechanisms, clinical application and so on. Moreover, this is the first time to put forward the theory of Yin‐Yang balance to understand trained immunity. We envision that more efforts will be focused on developing novel immunotherapies targeting trained immunity in the coming years.

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Section: The Yin‐yang Balance Of Trained Immunitymentioning

confidence: 99%

Section: The Yin‐yang Balance Of Trained Immunitymentioning

confidence: 99%

Section: The Amicable (Yang) Effects Of Trained Immunitymentioning

confidence: 99%

See 1 more Smart Citation

Trained immunity: A Yin‐Yang balance

Lowrie

et al. 2022

MedComm

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“…Similarly, Yan et al induced the activation and infiltration of monocytes and macrophages utilising β-glucan treatment, thereby reducing the tumour burden. 109 Mulder et al constructed a nano-biologic platform loaded with peptidoglycans, stearoyl fatty acid-modified 6- O -acyl muramyl dipeptide, and muramyl tripeptide phosphatidylethanolamine. 110 Given its high bone marrow avidity, this nano-platform could more effectively induce trained immunity.…”

Section: Chemical Strategies For Modulating the Tmementioning

confidence: 99%

New opportunities for immunomodulation of the tumour microenvironment using chemical tools

2022

Chem. Soc. Rev.

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“…Additionally, the remarkable LAMP3 gene expression in human regDCs was dismissed in the mouse (56). A similar situation occurred in the CRC/GC mouse model, in which the classification of DC cells was too broad (57,58). Additionally, DC gene expression in esophageal squamous cell carcinoma mouse models mostly does not match that in human tumors (59).…”

Section: The Difference Between Clinical Samples and Tumors From Mous...mentioning

confidence: 99%

Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond

et al. 2022

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Gastrointestinal (GI) cancers occur in the alimentary tract and accessory organs. They exert a global burden with high morbidity and mortality. Inside the tumor microenvironment, dendritic cells (DCs) are the most efficient antigen-presenting cells and are necessary for adaptive immune responses such as T and B-cell maturation. However, the subsets of DCs revealed before were mostly based on flow cytometry and bulk sequencing. With the development of single-cell RNA sequencing (scRNA-seq), the tumor and microenvironment heterogeneity of GI cancer has been illustrated. In this review, we summarize the classification and development trajectory of dendritic cells at the single-cell level in GI cancer. Additionally, we focused on the interaction of DCs with T cells and their effect on the response to immunotherapy. Specifically, we focused on the newly identified tumor-infiltrating dendritic cells and discuss their potential function in antitumor immunity.

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The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

Cited by 41 publications

References 84 publications

Trained immunity: A Yin‐Yang balance

Trained immunity: A Yin‐Yang balance

New opportunities for immunomodulation of the tumour microenvironment using chemical tools

Cell atlas of the immune microenvironment in gastrointestinal cancers: Dendritic cells and beyond

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