The induction of lymphoid follicle-like structures in the ovine teat duct following experimental infection with Mannheimia haemolytica

Fragkou, I.A.; Dagleish, Mark P.; Papaioannou, N.; Cripps, Peter; Boscos, C.; Ververidis, H.N.; Orfanou, D.C.; Σολωμάκος, Νικόλαος; Finlayson, J.; Govaris, Α.; Kyriazakis, Ι.; Fthenakis, George C.

doi:10.1016/j.tvjl.2009.01.025

Cited by 25 publications

(24 citation statements)

References 37 publications

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“…Candidate genes implicated in innate immunity and thus resistance to mastitis included SOCS2 , CTLA4 , C6 , C7 , C9 , PTGER4 , DAB2 , CARD6 , OSMR , PLXNC1 , IDH1 , ICOS , FYB and LYFR in Chios breed (Banos et al, ). Fragkou et al () have attributed the breed differences in susceptibility of mastitis to differences in lymphocyte activity and proposed a potential genetic background to the infection, given that in cattle, the genetics of bovine leucocyte antigen ( BoLA ) has been linked to resistance to mastitis (Takeshima & Aida, ).…”

Section: Animal‐related Predisposing Factorsmentioning

confidence: 99%

Predisposing factors for bacterial mastitis in ewes

Vasileiou

Mavrogianni

Petinaki

et al. 2019

Reprod Domestic Animals

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Objective of this review paper is the appraisal of predisposing factors for bacterial mastitis in ewes. Factors that predispose ewes to mastitis can be classified into non‐animal‐related factors (environmental and climatological factors, housing, nutrition, milking practices) and animal‐related factors (anatomic, genetic, litter size—ethological factors, number and stage of lactation period, health problems). There are clear management—environment—animal interactions in mastitis development in ewes, which underline its multifactorial nature. Research and studies regarding risk factors are important, in order to develop strategies for their elimination, control or correction. Control measures for bacterial mastitis, which attempt to eliminate predisposing factors for infection, can thus be developed and implemented.

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Section: Animal‐related Predisposing Factorsmentioning

confidence: 99%

Predisposing factors for bacterial mastitis in ewes

Vasileiou

Mavrogianni

Petinaki

et al. 2019

Reprod Domestic Animals

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“…Lymphoid hyperplasia identified in the lamina propria at the junction between the teat duct and teat cistern is considered to have a clear protective role to that structure (Mavrogianni et al, 2005). These focal lymphoid accumulations were later characterised and found to contain CD79 + , CD3 + , gd T cells, CD68 + and MHC-II + cells Fragkou et al, 2010). However, in cases of Orf Virus infection in the teats, these structures could not be observed (Mavrogianni et al, 2006a), as was also the case in chapped teats (Fragkou et al, 2007a).…”

Section: Pathogenetic Processesmentioning

confidence: 99%

“…There appeared to be a genetic background in the development of these lymphoid accumulations, as differences have been identified between breeds of dairy sheep in their presence and function (Fragkou et al, 2007b). It has been suggested that these lymphoepithelial structures develop following bacterial invasion and result from recruitment and expansion of antigen-specific lymphocytes in situ (Mavrogianni et al, 2005;Fragkou et al, 2010).…”

Section: Pathogenetic Processesmentioning

confidence: 99%

Mastitis in sheep – The last 10 years and the future of research

Gelasakis

Mavrogianni

Petridis

et al. 2015

Veterinary Microbiology

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144

126

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“…of S. chromogenes, as determined by the method of Miles and Misra [22]. The validity of these challenge models for inducing mastitis has been confirmed in many previous experimental studies [5,20,21,[23][24][25][26][27] by using clinical, bacteriological, cytological, ultrasonographic, proteomics and histological methods [6].…”

Section: Inoculation Proceduresmentioning

confidence: 75%

Detection of Cathelicidin-1 in the Milk as an Early Indicator of Mastitis in Ewes

et al. 2019

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The objective of the study was the investigation of the behaviour of cathelicidin-1 in the milk after experimental infection with two prominent bacterial pathogens (experiment 1: Mannheimia haemolytica, experiment 2: M. haemolytica and Staphylococcus chromogenes) as a potential early indicator for diagnosis of mastitis in sheep. In two experiments, after bacterial inoculation into the udder of ewes, bacteriological and cytological examinations of milk samples as well as proteomics examinations [two-dimensional gel electrophoresis analysis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI-TOF MS) analysis] were performed sequentially. Cathelicidin-1 was detected and spot densities obtained from PDQuest v.8.0 were recorded. Associations were calculated between cell content and spot densities as well as between presence of mastitis in a mammary gland at a given time-point and detection of cathelicidin-1 in the respective milk sample. All inoculated mammary glands developed mastitis, confirmed by the consistent bacterial isolation from mammary secretion and increased leucocyte content therein. Spot density of cathelicidin-1 in samples from inoculated glands increased 3 h post-inoculation; spot density of cathelicidin-1 in samples from inoculated glands was higher than in samples from uninoculated controls. There was clear evidence of correlation between cell content and cathelicidin-1 spot densities in milk samples. There was significant association between presence of mastitis in the mammary gland and detection of cathelicidin-1 in the respective milk sample; overall accuracy was 0.818—this was significantly greater during the first 24 h post-challenge (0.903) than after the first day (0.704). In conclusion, detection of cathelicidin-1 in milk was significantly associated with presence of mastitis in ewes. The associations were stronger during the first 24 h post-infection than after the first day. Cathelicidin-1 has the advantage that it can be a non-specific biomarker, as simply a “positive”/“negative” assessment would be sufficient.

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The induction of lymphoid follicle-like structures in the ovine teat duct following experimental infection with Mannheimia haemolytica

Cited by 25 publications

References 37 publications

Predisposing factors for bacterial mastitis in ewes

Predisposing factors for bacterial mastitis in ewes

Mastitis in sheep – The last 10 years and the future of research

Detection of Cathelicidin-1 in the Milk as an Early Indicator of Mastitis in Ewes

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