The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) in prostate cancer patients undergoing androgen deprivation therapy: study protocol for a randomized controlled trial

Focht, Brian C.; Lucas, Alexander R.; Grainger, Elizabeth M.; Simpson, Christina; Thomas‐Ahner, Jennifer M.; Clinton, Steven K.

doi:10.1186/1745-6215-15-354

Cited by 15 publications

(24 citation statements)

References 55 publications

(60 reference statements)

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“…Only two randomized trials looked at this important facet; one showed a reduction in C-reactive protein after 12 weeks of exercise, but no differences in systolic blood pressure, blood glucose, or lipids was demonstrated. 75 A further prospective randomized trial of dietary and exercise intervention is underway, 76 but while these important studies may yield benefits to prostate cancer patients, they are unlikely to be able to demonstrate whether such interventions are capable of ameliorating the risks associated with ADT. 74 – 77 What is clear is that in the general population, cardiac rehabilitation programs that primarily utilize exercise produce compelling and consistent clinical results in men with preexisting cardiovascular disease.…”

Section: Basic Physiologymentioning

confidence: 99%

Cardiovascular effects of hormone therapy for prostate cancer

Lester¹,

Mason²

2015

DHPS

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Androgen deprivation therapy (ADT) has been the mainstay of treatment for advanced prostate cancer for decades, and has been shown to control disease and improve symptoms. In addition, for men with high-risk localized or locally advanced prostate cancer, short-course ADT in combination with radiotherapy improves survival. There is evidence that ADT increases cardiovascular risk, particularly in men with preexisting cardiovascular disease. This increased risk may apply even with short-course ADT. In an individual patient, the benefits of ADT should be balanced against the risk, and patients who require ADT should have risk factors for cardiovascular disease optimized. There is some evidence to suggest that more contemporary methods of delivering ADT may reduce cardiovascular risk.

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Section: Basic Physiologymentioning

confidence: 99%

Cardiovascular effects of hormone therapy for prostate cancer

Lester¹,

Mason²

2015

DHPS

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“…The Mindfulness in Motion and the Dietary counselling portions of the intervention have both been previously validated in research studies. 24 , 26 , 68 However, this was the first time they have been combined to target a unique population of cancer survivors in order to improve lifestyle behaviors and potentially relevant health outcomes. Most traditional approaches to weight loss (increasing PA and improving diet) may be seen as particularly challenging for women who are dealing with a diagnosis of cancer, obesity, and trying to manage multiple comorbidities.…”

Section: Discussionmentioning

confidence: 99%

A Mindfulness-Based Lifestyle Intervention for Obese, Inactive Endometrial Cancer Survivors: A Feasibility Study

et al. 2016

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Background: Mindfulness-based interventions (MBIs) to address self-regulation and lifestyle behaviors (diet, physical activity) may benefit endometrial cancer survivors (ECS), who are at increased risk for morbidity and mortality associated with obesity. However, the acceptability of mindfulness training and whether it can augment behavior change in ECS is unknown. We aimed to examine; 1) the feasibility of the Mindfulness in Motion + Diet (MIM+D) intervention and 2) the preliminary efficacy of MIM+D for improving mindfulness, diet, PA and health-related quality of life (HRQL). Methods: ECS (Mage=62.4, ±5yrs from diagnosis) completed assessments at baseline, 8 and 14 weeks. Feasibility was determined by intervention completion surveys, attendance and adherence data. We used repeated measures ANOVA’s (SPSS 22.0) and effect size estimates (Cohen’s d) to examine changes in mindfulness, diet, PA, and HRQL over time. Results: Thirteen ECS (76%) completed the MIM+D program and attendance (≥6/8 sessions) was 90%. Women reported favorably on the overall quality (mean of 4.75/5) and benefits of the MIM+D program; however, would have preferred receiving MIM+D closer to diagnosis. Intention to treat analyses found MIM+D did not significantly improve any outcomes. However, an intervention completers analysis showed significant change in mindfulness (p=.0039) and small to moderate estimates for change in fruits and vegetable intake (d=.23), MVPA (d=.45), RAND SF-36: MCS (d=.46), and sleep quality (d=.68). Conclusions: Integrating mindfulness training into behavioral interventions is feasible and ECS that adhere to these lifestyle programs may benefit. However, to future research should examine the-long term effects of mindfulness-based behavioral lifestyle interventions.

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“…Study support was provided by National Cancer Institute Grant #R03 CA16296901 (Trial Registration: NCT02050906 Registered; 24 January 2014). Detailed reports of the study design, trial procedures, and interventions have been published previously 34–36 . A brief summary of the relevant methods and procedures is provided here.…”

Section: Methodsmentioning

confidence: 99%

Effects of a Lifestyle Intervention on Change in Body Composition in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy

Chaplow

Focht

Lucas

et al. 2018

Medicine &Amp; Science in Sports &Amp; Exercise

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Background Exercise and dietary (EX+D) interventions could represent an optimal treatment for attenuating or reversing adverse effects of androgen deprivation therapy (ADT) in prostate cancer (PCa) patients. The Individualized Diet and Exercise Adherence-Pilot (IDEA-P) trial compared the effects of an EX+D intervention relative to standard-of-care (SC) treatment among PCa patients undergoing ADT. The present study evaluated the effects of the EX+D intervention on body composition (BC) obtained via dual-energy X-ray absorptiometry (DXA) in a subsample of IDEA-P patients. A secondary objective was to explore the association of adiposity and lean mass with mobility performance and strength. Methods Complete DXA data were acquired from a subsample of 22 PCa patients (EX+D: n = 13; SC: n = 9) at baseline and 3 month follow-up. Intention-to-treat analysis included data from 30 participants (M age = 66.28; SD = 7.79) with baseline DXA assessments.Results Intention-to-treat analysis revealed EX+D resulted in significant improvements in fat mass (P = 0.022), per cent fat mass (P = 0.028), trunk fat mass (P = 0.017), fat mass/lean mass (P = 0.040), and per cent lean mass (P = 0.026) vs. SC. EX +D also resulted in more favourable changes in appendicular lean mass/body mass (d = 0.59). Select BC outcomes were also significantly correlated with mobility performance and strength (P < 0.05) at 3 month follow-up. Conclusions Findings suggest the EX+D intervention resulted in superior preservation of lean tissue and improvement in adiposity relative to SC treatment. Results underscore the utility of implementing EX+D interventions for preserving muscle mass and reducing adiposity in PCa patients undergoing ADT.

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The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) in prostate cancer patients undergoing androgen deprivation therapy: study protocol for a randomized controlled trial

Cited by 15 publications

References 55 publications

Cardiovascular effects of hormone therapy for prostate cancer

Cardiovascular effects of hormone therapy for prostate cancer

A Mindfulness-Based Lifestyle Intervention for Obese, Inactive Endometrial Cancer Survivors: A Feasibility Study

Effects of a Lifestyle Intervention on Change in Body Composition in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy

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