The indirect antinociceptive mechanism of 15<scp>d</scp>‐<scp>PGJ</scp><sub>2</sub> on rheumatoid arthritis‐induced <scp>TMJ</scp> inflammatory pain in rats

Quinteiro, Mariana; Napimoga, Marcelo Henrique; Mesquita, K.P.; Clemente-Napimoga, Juliana Trindade

doi:10.1002/j.1532-2149.2012.00114.x

Cited by 26 publications

(43 citation statements)

References 46 publications

(62 reference statements)

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“…The arthritic rats showed no visible signs of evoked or spontaneous pain prior to formalin TMJ stimulation. However, low-dose formalin (0.5%), known not to induce pain-related behaviors in normal animals [ 27 ], induced a significant increase of facial grimacing, head flinching, facial rubbing, and bilateral mechanical allodynia ( Figure 2 and Figure 3 ), in accordance with previous studies [ 8 , 28 ]. This suggests that the mBSA-induced monoarthritis is nonpainful per se; however, it induces a profound chemical hypersensitivity to normally nonpainful concentrations of inflammatory substances such as formalin [ 12 ].…”

Section: Discussionsupporting

confidence: 89%

Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats

Muñoz-Lora

Okroša

Matak

et al. 2022

Toxins

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Botulinum neurotoxin type A1 (BoNT-A) reduces the peripheral peptide and cytokine upregulation in rats with antigen-evoked persistent immunogenic hypersensitivity (PIH) of the temporomandibular joint (TMJ). Herein, we examined the effects of two preparations of BoNT-A, abobotulinumtoxinA (aboBoNT-A; Dysport) and onabotulinumtoxinA (onaBoNT-A; Botox), on spontaneous and evoked nociceptive behaviors, as well as on central neuronal and astroglial activation. The antigen-evoked PIH was induced in rats via repeated systemic and unilateral intra-articular (i.a.) injections of methylated bovine serum albumin (mBSA). Rats were subsequently injected with unilateral i.a. aboBoNT-A (14 U/kg), onaBoNT-A (7 U/kg), or the vehicle (saline). After i.a. treatments, spontaneous and mechanically evoked nocifensive behaviors were assessed before and after the low-dose i.a. formalin (0.5%) challenge. The central effects of BoNT-A were assessed by an immunohistochemical analysis of cleaved synaptosomal-associated protein 25 (cSNAP-25) presence, c-Fos, GFAP, and CGRP expression in the trigeminal nucleus caudalis (TNC). Both BoNT-A preparations similarly reduced the formalin-induced spontaneous pain-related behaviors and mechanical allodynia of the hypernociceptive rats. Likewise, their effects were associated with the central occurrence of cSNAP-25 and reduction of c-Fos and GFAP upregulation in the TNC. BoNT-A antinociceptive activity on the PIH is associated with the toxin axonal transport to trigeminal sensory areas and reduction of neuronal and glial activation in central nociceptive regions.

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Section: Discussionsupporting

confidence: 89%

Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats

Muñoz-Lora

Okroša

Matak

et al. 2022

Toxins

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“…Clinical and experimental research on the pathogenesis and mediators involved in the pain process has been widely developed in the last 20 years. Although some mechanisms involved in this process have already been thoroughly described, others remain to be elucidated [ 16 – 19 ]. In this context, despite being considered of great relevance in the modulation of inflammatory events and studied in a considerable variety of human diseases [ 20 ], oxidative stress has not yet been investigated in clinical models of preemptive analgesia related to third molars surgery.…”

Section: Introductionmentioning

confidence: 99%

Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial

et al. 2022

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Objective The aim of this study is to compare the effect of photobiomodulation with low-level laser therapy (LLLT) and nimesulide on inflammatory parameters, biomarkers of oxidative stress and inflammation, and quality of life after lower third molar (L3M) surgery. Material and methods A randomized, two-factor, triple-blind, controlled, split-mouth clinical trial was performed with 40 volunteers who required bilateral L3M removal. Patients were allocated depending on the use or not of 100 mg nimesulide 1 hbefore surgery, as well as the use or not of LLLT in the preoperative period. Results Pain peaks occurred after 6 h (nimesulide-placebo [N-P] group) and 8 h (nimesulide group). In the N-P group, LLLT resulted in significantly lower mean pain scores than the subgroup without LLLT after 4 h ( p = 0.009) and 6 h ( p = 0.048). As for edema, a shorter distance between the mandibular angle and the outer canthus of the eyes after 7 days ( p = 0.037) and a smaller cumulative effect ( p = 0.036) were observed in the N-P group associated with LLLT. A direct effect between LLLT ( p = 0.047) and a reduction in the mean scores of overall dissatisfaction with quality of life was detected. Conclusions Preemptive use of nimesulide only delayed peak pain. LLLT reduced edema, trismus, and contributed to a better perception of quality of life. Nimesulide inhibits peroxidation by increasing GSH and stopping neutrophil migration. The benefit of the association of both strategies was not superior to the use of LLLT alone. Clinical relevance Translational study with impact on clinical-surgical protocols involving L3M surgery related to pharmacological and non-pharmacological methods.

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“…Certain mechanisms have been proposed to explain the inflammation that occurs as a result of surgical procedures, but a complete understanding of how these events are fully triggered remains unclear. Proinflammatory cytokines such as TNF-a and interleukin 1 beta (IL-1b) have often been described as important mediators in this process [10][11][12][13] . Experimental studies involving acute pain models suggest that IL-1b sensitizes nociceptors and causes hyperalgesia, therefore working actively in the pathophysiology of this type of pain [14][15][16] .…”

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confidence: 99%

Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study

Albuquerque

Fonteles

Val

et al. 2017

International Journal of Oral and Maxillofacial Surgery

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This study aimed to evaluate whether pre-emptive analgesia modifies the tissue expression of tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), and whether there is an association with postoperative surgical outcomes. A triple-blind, randomized, placebo-controlled study of patients undergoing mandibular third molar removal was performed. Volunteers were allocated randomly to receive etoricoxib 120 mg, ibuprofen 400 mg, or placebo 1h before surgery. Twenty-four surgical sites per group were required (95% confidence level and 80% statistical power). Pain scores differed significantly between groups (P<0.001). Etoricoxib and ibuprofen reduced pain scores compared to placebo (P<0.05). Pain scores peaked at 4h postoperative in the experimental groups, but at 2h postoperative in the placebo group (P<0.05). A significant reduction in TNF-α concentration from time 0' to time 30' was seen for ibuprofen (P=0.001) and etoricoxib (P=0.016). The ibuprofen group showed a significant reduction in IL-1β levels from time 0' to time 30' (P=0.038). In conclusion, TNF-α and IL-1β levels and the inflammatory events in third molar surgery were inversely associated with the degree of cyclooxygenase 2 selectivity of the non-steroidal anti-inflammatory drugs used pre-emptively. Patients given pre-emptive analgesia showed significant reductions in the clinical parameters pain, trismus, and oedema when compared to the placebo group.

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The indirect antinociceptive mechanism of 15d‐PGJ₂ on rheumatoid arthritis‐induced TMJ inflammatory pain in rats

Abstract: In the present study, we demonstrated that 15d-PGJ2 was able to reduce the RA-induced TMJ inflammatory hypernociception by an indirect mechanism. This antinociceptive effect is in part due to decrease of TNF-α, IL-1β and KC levels and PKA/PKCε expression in the TMJ.

Cited by 26 publications

References 46 publications

Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats

Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats

Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial

Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study

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The indirect antinociceptive mechanism of 15d‐PGJ2 on rheumatoid arthritis‐induced TMJ inflammatory pain in rats

Abstract: In the present study, we demonstrated that 15d-PGJ2 was able to reduce the RA-induced TMJ inflammatory hypernociception by an indirect mechanism. This antinociceptive effect is in part due to decrease of TNF-α, IL-1β and KC levels and PKA/PKCε expression in the TMJ.

Cited by 26 publications

References 46 publications

Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats

Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats

Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial

Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-α and IL-1β in third molar surgery: a triple-blind, randomized, placebo-controlled study

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The indirect antinociceptive mechanism of 15d‐PGJ₂ on rheumatoid arthritis‐induced TMJ inflammatory pain in rats