subjects with type 2 diabetes status, whereas no exercise was superior to resistance and combined exercise for improving mental health status. The authors claimed insufficient statistical power and/or the effect of fatigue to explain the lack of improvement in the physical component summary measures with mixed training and attributed to a "reversion to the mean" phenomenon the improvement in the mental component summary measures in the control group, starting with a lower mean score at baseline than the exercise intervention groups.A possible limitation of this study, in addition to intrinsic limitation of the SF-36 survey, is the unblinded design, though blinding is not feasible in clinical trials using behavioral interventions. Strengths of this study are that it was multicenter, thus less dependent on local factors, and of larger size and longer duration than other exercise intervention trials in patients with type 2 diabetes, including those assessing QoL and well-being measures. [2][3][4] In conclusion, this large trial shows that the health benefits induced by supervised mixed exercise training on top of counseling include a significant improvement of physical and mental health-related QoL measures. Thus, this intervention strategy may be effective for promoting permanent lifestyle changes in subjects with sedentary habits, such as patients with type 2 diabetes.