The increasing threat of Pseudomonas aeruginosa high-risk clones

Oliver, Antonio; Mulet, Xavier; López-Causapé, Carla

doi:10.1016/j.drup.2015.08.002

Cited by 523 publications

(596 citation statements)

References 203 publications

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“…® /E-test negative which was susceptible to CAZ, but resistant to TIC, TIM, TPZ, FEP could suffer a mutation that causes Mex-EF-OprN hyperproduction combined with OprD downregulation, a mechanism more rarely seen, which primarily affects fluoroquinolones (20). MBLs hydrolyse all β-lactams, except monobactams, whose representative is ATM (23).…”

Section: Genotypic Detection Of Genes Encoding Mbls (Blaimp Blavmentioning

confidence: 99%

“…All the blaVIM+ strains were resistant to ciprofloxacin while 2 out of 4 blaIMP+ strains were susceptible to ciprofloxacin. It could be explained by presence of multiple mechanisms of resistance, such as the MBL synthesis associated with the expression of efflux pumps MexAB-OprM or MexXY, responsible for associated resistance to fluoroquinolones (20). It is possible that a strain produces more types of carbapenemases.…”

Section: Genotypic Detection Of Genes Encoding Mbls (Blaimp Blavmentioning

confidence: 99%

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Phenotypic and genotypic study of carbapenem-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients

Matros

Krausz

Pandrea

et al. 2016

Revista Romana De Medicina De Laborator

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Introduction: Nosocomial infections caused by Pseudomonas aeruginosa producing carbapenemases represent an important cause of morbidity and mortality among immunosuppressed patients. The aim of our study was to detect the production of metallo-carbapenemases (MBLs) by phenotypic methods and to detect the presence of the MBLs encoding genes (blaIMP and blaVIM) by PCR in P. aeruginosa strains isolated from hospitalized patients to the

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Section: Genotypic Detection Of Genes Encoding Mbls (Blaimp Blavmentioning

confidence: 99%

Section: Genotypic Detection Of Genes Encoding Mbls (Blaimp Blavmentioning

confidence: 99%

Phenotypic and genotypic study of carbapenem-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients

Matros

Krausz

Pandrea

et al. 2016

Revista Romana De Medicina De Laborator

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“…It particularly affects immunocompromised patients or those admitted to the intensive care unit (ICU). P. aeruginosa is the primary pathogenic agent in burn wound infections and ventilator associated pneumonia, both of which are associated with a considerably high (> 30%) mortality rate (1). The bacterium is also responsible for a variety of nosocomial infections, such as urinary tract or wound infections, endocarditis, and bacteremia (2).…”

Section: Introductionmentioning

confidence: 99%

“…Because of the adaptability of P. aeruginosa and its exceptionally good capacity to evade the activity of antimicrobial drugs, this bacterium is one of the most feared pathogens. Today, the increased prevalence of nosocomial infections caused by extreme drug-resistant and multidrug-resistant P. aeruginosa strains considerably limits the selection of proper antibiotics and therefore increases the morbidity and mortality of patients (1,4,5).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Effects of Ferula persica Gum Extract and Gold Nanoparticles on Pseudomonas aeruginosa

Nejad¹,

Bamzadeh²,

Hejazi³

2016

Avicenna J Clin Microbiol Infect

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Background: In the treatment of bacterial infections, drug resistance is a global problem; Pseudomonas aeruginosa is no exception. This bacterium is among the important causes of nosocomial infections, especially burn wound infections, and it is resistant to most applicable antibiotics. Objectives: The present study aimed to evaluate the anti-bacterial effects of Ferula persica gum extract and gold nanoparticles on P. aeruginosa strains isolated from burn wound infections in Isfahan in 2012. Materials and Methods: In this experimental study, 150 P. aeruginosa strains carrying the blaSPM-1 gene were isolated from burn wound infections and were confirmed by biochemical tests. The anti-microbial activities of Ferula persica gum extract and gold nanoparticles were evaluated by agar well-diffusion assay and microdilution antimicrobial susceptibility tests. The results were compared to ciprofloxacin. Results: The highest mean zone of inhibition (18 mm) was observed in a concentration of 250 mg/mL of F. persica extract, which was equal to that of ciprofloxacin. In the gold nanoparticles, the highest mean growth inhibition zone (10.18 mm) was observed in the dilution of 50 ppm. The highest zone of inhibition of nanoparticle-extract synergy was observed in the dilution of 125 mg/mL

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Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess

Lewis

Cluck

Tharp

et al. 2018

Clinical Case Reports

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Key Clinical MessageTreatment of Pseudomonas aeruginosa remains challenging, despite the availability ceftolozane‐tazobactam. We report a treatment failure with ceftolozane‐tazobactam salvage therapy for pneumonia complicated by lung abscess. Drug resistance, dose selection, and source control are possible contributing factors. Ceftolozane‐tazobactam susceptibility testing should precede therapy and consideration should be given to dosing selection.

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The increasing threat of Pseudomonas aeruginosa high-risk clones

Cited by 523 publications

References 203 publications

Phenotypic and genotypic study of carbapenem-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients

Phenotypic and genotypic study of carbapenem-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients

Antimicrobial Effects of Ferula persica Gum Extract and Gold Nanoparticles on Pseudomonas aeruginosa

Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess

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