The Increasing Prevalence of Gastroschisis: Associated Factors, Possible Mechanisms, and Potential Mitigative Interventions

Hughes, Claude L.; Adibe, Obinna O.

doi:10.36316/gcatr.01.0002

Cited by 3 publications

(2 citation statements)

References 85 publications

(71 reference statements)

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“…Gastroschisis has increased globally over recent decades, and this increase is not explained by demographic changes in maternal age or other identified risk factors. The cause is believed to be multifactorial and primarily non-genetic/epigenetic, but its etiology remains unknown 3 – 6 . Lifestyle behaviours, environmental exposures, substance or alcohol use, tobacco smoking, poor nutrition, lower dietary intake of vitamin D and sociodemographic risk factors have been frequently or occasionally associated with an increase in gastroschisis 6 – 8 , young maternal age is the only confirmed risk factor, while the etiology remains obscure.…”

Section: Introductionmentioning

confidence: 99%

“…The cause is believed to be multifactorial and primarily non-genetic/epigenetic, but its etiology remains unknown 3 – 6 . Lifestyle behaviours, environmental exposures, substance or alcohol use, tobacco smoking, poor nutrition, lower dietary intake of vitamin D and sociodemographic risk factors have been frequently or occasionally associated with an increase in gastroschisis 6 – 8 , young maternal age is the only confirmed risk factor, while the etiology remains obscure. For example, a 7 times higher risk of gastroschisis is typically observed in women < 20 years of age than women aged 25–29 years.…”

Section: Introductionmentioning

confidence: 99%

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Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada

Liu,

Claude,

Yong

et al. 2023

Sci Rep

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Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004–2020. We used “winter” months (i.e., September through June) and northern areas of residence as indicators of less sunlight/less active lifestyle, while “summer” (i.e., July and August) and southern areas were considered as reference. Rate of gastroschisis for infants conceived in winter (3.4 per 10,000) was higher than for infants conceived in summer (2.2 per 10,000; p < 0.001). Exposure to winter, and northern area, hypothyroidism, substance or tobacco uses and depressive disorder were initially identified as risk factors for gastroschisis. There was a significant interaction between women < 24 years of age and 2-month conception intervals (rate ratio (RR): 1.42 (95% confidence interval [CI] 1.19–1.70). The association of maternal depression (mean ratio 2.19, 95% CI 0.87–3.50, p = 0.001) with infant gastroschisis was mediated by hypothyroidism (mean ratio 1.04, 95% CI 1.01–1.07, p < 0.001), whereas substance use, hypothyroidism, tobacco smoking and gestational diabetes showed 5.5-, 3.1-, 2.7-, and 1.2-fold associations, respectively, with maternal depression. In contrast to the summer conception interval of low gastroschisis risk, an elevated risk of gastroschisis spans the other ten months in association with higher levels of stress adaptation, thermoregulation and metabolism, reproduction, and growth effector hormones. Our findings suggest that periconception depression with mediation by hypothyroidism, may play a causal role in offspring gastroschisis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada

Liu,

Claude,

Yong

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

Association of maternal depression and hypothyroidism with infant gastroschisis: A population-based cohort study in Canada

Liu

Hughes

Yong

et al. 2023

Preprint

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Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004–2020. We used “winter” months (i.e., September through June) and northern areas of residence as indicators of less sunlight/less active lifestyle, while “summer” (i.e., July and August) and southern areas were considered as reference. Rate of gastroschisis for infants conceived in winter (3.4 per 10 000) was higher than for infants conceived in summer (2.2 per 10 000; p < 0.001). Exposure to winter, and northern area hypothyroidism, substance or tobacco uses and depressive disorder were initially identified as risk factors for gastroschisis. There was a significant interaction between women < 24 years of age and 2-month conception intervals (rate ratio (RR): 1.42 (95% confidence interval [CI] 1.19–1.70). The association of maternal depression (mean ratio 2.19, 95% CI 0.87–3.50, p = 0.001) with infant gastroschisis was mediated by hypothyroidism (mean ratio 1.04, 95%CI 1.01–1.07, p < 0.001), whereas substance use, hypothyroidism, tobacco smoking and gestational diabetes showed 5.5-, 3.1-, 2.7, and 1.2-fold associations, respectively, with maternal depression. In contrast to the summer conception interval of low gastroschisis risk, an elevated risk of gastroschisis spans the other ten months in association with higher levels of stress adaptation, thermoregulation and metabolism, reproduction, and growth effector hormones. Our findings suggest that periconception depression may play a causal role in offspring gastroschisis.

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Ecological Analysis of Gastroschisis Incidence Decline in Liaoning, China, 2006-2016

Zhang²,

Hughes

et al. 2020

Glob Clin Transl Res

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Background: A gastroschisis incidence decline has recently been reported in Liaoning, China, from 2006-2015; we suspect that this decline could be associated with the fall in industrial manufacturing activities. Methods: The outcome variable, gastroschisis incidence, was from a previous publication. The industrial manufacturing activities were measured by relative job participation and production in the primary and secondary economic sectors, and the corresponding data were collected in 14 cities from 2005 to 2015. The general linear model and a random-effect Poisson regression model were performed to assess the association and time-series trend of gastroschisis with the manufacturing activities. Results: The relative job participation in the first economic sector was marginally associated with gastroschisis incidence in 2006 (p=0.070), but more significantly associated (Beta=-0.040; p=0.014) in the cross-sectional and time-series analysis with one-year lag in the outcome variable. Conclusion: The gastroschisis incidence decline in Liaoning is likely due to the reduced job participation in manufacturing and heavy industry, which might be an indication of reduced risk exposure associated with the industrial manufacturing activities.

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The Increasing Prevalence of Gastroschisis: Associated Factors, Possible Mechanisms, and Potential Mitigative Interventions

Cited by 3 publications

References 85 publications

Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada

Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada

Association of maternal depression and hypothyroidism with infant gastroschisis: A population-based cohort study in Canada

Ecological Analysis of Gastroschisis Incidence Decline in Liaoning, China, 2006-2016

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