The increasing importance of the novel Coronavirus

Mungroo, Mohammad Ridwane; Khan, Naveed Ahmed; Siddiqui, Ruqaiyyah

doi:10.1080/21548331.2020.1828888

Cited by 10 publications

(13 citation statements)

References 83 publications

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“…A large number of SARS-CoV-2-infected patients exhibit a mild-to-moderate illness, about 5-10% of the infections occur serious and life-threatening cases, and the mortality rate is about 2% [37]. The number of new confirmed patients continues to increase, highlighting the importance of the development of rapid and effective therapeutic strategies by the design of new specific drugs or the repurposing of existing drugs [38]. Herein, we summarize the therapeutic effects of the existing drugs and substances from three aspects based on potential targets: virus entry, virus replication, and the immune system (Figure 2).…”

Section: Potential Therapeutic Strategiesmentioning

confidence: 99%

A Review of Potential Therapeutic Strategies for COVID-19

Meng

Zhang

et al. 2022

Viruses

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Coronavirus disease 2019 is a rather heterogeneous disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat with increasing death tolls worldwide. SARS-CoV-2 belongs to lineage B β-CoV, a subgroup of Sarbecovirus. These enveloped, large, positive-sense single-stranded RNA viruses are easily spread among individuals, mainly via the respiratory system and droplets. Although the disease has been gradually controlled in many countries, once social restrictions are relaxed the virus may rebound, leading to a more severe and uncontrollable situation again, as occurred in Shanghai, China, in 2022. The current global health threat calls for the urgent development of effective therapeutic options for the treatment and prevention of SARS-CoV-2 infection. This systematic overview of possible SARS-CoV-2 therapeutic strategies from 2019 to 2022 indicates three potential targets: virus entry, virus replication, and the immune system. The information provided in this review will aid the development of more potent and specific antiviral compounds.

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Section: Potential Therapeutic Strategiesmentioning

confidence: 99%

A Review of Potential Therapeutic Strategies for COVID-19

Meng

Zhang

et al. 2022

Viruses

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“…Due to the anti-inflammatory properties of corticosteroids, it has been proposed that they could be used to treat or decrease COVID-19 infection complications [ 9 , 10 , 11 ]. Numerous studies revealed that the use of corticosteroids on non-cancer patients was associated with a 28-day reduction in mortality [ 9 ] and an increase in the number of days spent without the assistance of mechanical ventilation, particularly in patients who were critically ill [ 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Dexamethasone Corticosteroid Therapy’s Effect on COVID-19 Prognosis in Cancer Patients: A Retrospective Study

et al. 2023

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Background: Anti-inflammatory corticosteroids are used in cancer treatment and COVID-19 infections. Data on the impact of non-dexamethasone corticosteroids on COVID-19 infection severity in cancer patients are minimal. This study investigates if corticosteroid treatment affects the disease severity in adult cancer patients. Methods: A total of 116 COVID-19-infected cancer patients on hydrocortisone (H) or prednisone (P) were compared to 343 untreated patients. The study included patients who received corticosteroids before (B), after (A), or both before and after (B and A) COVID-19 infections. Ventilation support, hospitalization and mortality were investigated. Results: Our data showed that a significantly greater number of patients taking H or P required ventilation support and hospitalization and that mortality rates were higher than the control group. Patients who received H or P after COVID-19 infection had a significantly worse prognosis than the other sub-groups and the control group. Conclusion: Corticosteroids impacted cancer patients’ COVID-19 prognosis. Despite the limited sample size, H- and P-treated patients’ corticosteroids performed worse than the control, especially if treatments were received after COVID-19 infection. Hence, when a cancer patient already on H or P treatment is diagnosed with COVID-19, we recommend switching to a steroid treatment as suggested by international guidelines.

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“…The Discovery of COVID-19 is grounded on the virological discovery by RT-PCR using hearties (nasopharynx, oropharynx), foam, feces, and also other suggestive attestations seen on casket radiographs and dynamic monitoring of seditious intercessors(e.g., cytokines). Utmost standard patterns observed on casket CT were ground-glass nebulosity, ill-de ned perimeters, smooth or irregular interlobular septal thickening, air bronchogram, crazy-paving pattern, and thickening of the conterminous pleura ( 13,14).…”

Section: Introductionmentioning

confidence: 99%

Treatment outcomes of mechanically ventilated patients with COVID-19 and associated factors at the ICU of SPHMMC, Addis Ababa, Ethiopia

korbu,

Solomon,

Aklog

et al. 2023

Preprint

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Introduction: Coronavirus (CoV) is derived from the word ‘corona’ meaning ‘crown’ in Latin. Coronavirus causes a range of human respiratory tract infections varying from mild cold to severe respiratory distress syndrome. Nowadays, due to the limited number of ICU beds and ventilators and the increasing number of patients with COVID-19 infection requiring MV data on patient characteristics, and outcomes of critical illness from COVID-19 are needed to inform decision-making about resource allocation, critical care capacity, and treatment of patients. Objectives: To assess outcomes and associatedfactors of patients with COVID-19 on Mechanical ventilation at SPHMMC COVID ICU, Addis Ababa, Ethiopia, 2020 G.C. Methods: A single center cross-sectional study was used. All consecutive ICU admitted patients with RT-PCR confirmed COVID-19 and received mechanical ventilation support during the first 5 months were included. Data was collected from patient’s medical records using a structured questionnaireand the collected data was entered and analyzed using SPSS version 24. Results:A total of 104 ICU patients with COVID-19 were included. The majority, 73.1% were male; the median age was 60 (IQR; 45-70) years, with 36.5% patients having at least one chronic medical condition. Out of 165, 104 (63%) patients needed Mechanical Ventilation. Invasive and noninvasive ventilation were used in 93(89.4%) and 11(10.6%) patients, respectively. The most common treatments used by the patients were steroid (100%), antibiotics (99%) and vaso-pressors (57.7%). Experimental antiviral therapy was used in only 1% (n=1) of patients. Overall The ICU mortality was 14.6% and 88.5% among mechanically ventilated patients. Being fatigue (AOR=7.599 ; 95% CI: 1.65–35.12), IMV ((AOR=5.28; 95% CI: 1.01–27.71), and septic shock (AOR=12.83; 95% CI: 1.46-13.11) were a significant risk factors for the ICU outcomes of the patients Conclusion:The study showed high proportion of mortality among ICU patients who received mechanical ventilator support with low rate of discharge. Male patients and old age groups with co-morbidity were disproportionately affected by the disease condition.

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The increasing importance of the novel Coronavirus

Cited by 10 publications

References 83 publications

A Review of Potential Therapeutic Strategies for COVID-19

A Review of Potential Therapeutic Strategies for COVID-19

Non-Dexamethasone Corticosteroid Therapy’s Effect on COVID-19 Prognosis in Cancer Patients: A Retrospective Study

Treatment outcomes of mechanically ventilated patients with COVID-19 and associated factors at the ICU of SPHMMC, Addis Ababa, Ethiopia

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