The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease

Sugihara, Takahiko; Kobori, Ayako; Imaeda, Hirotsugu; Tsujikawa, Tomoyuki; Amagase, Kikuko; Takeuchi, Koji; Fujiyama, Yoshihide; Andoh, Akira

doi:10.1111/j.1365-2249.2010.04093.x

Cited by 106 publications

(74 citation statements)

References 54 publications

(86 reference statements)

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“…IBD can be classified into two major types, Crohn disease (CD) and ulcerative colitis (UC). IL-17A level was found to be upregulated in either CD or UC patients specimens [66,259]. The expression of IL-17F was also higher in CD patients compared with UC patients [241].…”

Section: Th17 Effector Cytokines In Autoimmune Diseasesmentioning

confidence: 84%

Th17 Differentiation and Their Pro-inflammation Function

Song

Gao

Qian

2014

Advances in Experimental Medicine and Biology

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CD4(+) T helper cells are classical but constantly reinterpreted T-cell subset, playing critical roles in a diverse range of inflammatory responses or diseases. Depending on the cytokines they release and the immune responses they mediate, CD4(+) T cells are classically divided into two major cell populations: Th1 and Th2 cells. However, recent studies challenged this Th1/Th2 paradigm by discovering several T-helper cell subsets with specific differentiation program and functions, including Th17 cells, Treg cells, and Tfh cells. In this chapter, we summarize the current understanding and recent progresses on the Th17 lineage differentiation and its effector impacts on variety of inflammatory responses or disease pathogenesis.

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Section: Th17 Effector Cytokines In Autoimmune Diseasesmentioning

confidence: 84%

Th17 Differentiation and Their Pro-inflammation Function

Song

Gao

Qian

2014

Advances in Experimental Medicine and Biology

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“…Clinically, the IL-17 level is elevated in both UC and CD patient specimens. 86,87 IL-17F expression is higher in CD patients than UC patients. 88 Several genome-wide association studies (GWASs) have shown that the genes critical for Th17 responses and IL-17 signaling (that is, STAT3, IL-23R, Functional mechanisms of IL-17 family cytokines X Song et al CCR6 and Act1) are associated with IBD pathogenesis in humans.…”

Section: Il-17dmentioning

confidence: 94%

The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity

et al. 2016

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The mucosal immune system serves as our front-line defense against pathogens. It also tightly maintains immune tolerance to self-symbiotic bacteria, which are usually called commensals. Sensing both types of microorganisms is modulated by signalling primarily through various pattern-recognition receptors (PRRs) on barrier epithelial cells or immune cells. After sensing, proinflammatory molecules such as cytokines are released by these cells to mediate either defensive or tolerant responses. The interleukin-17 (IL-17) family members belong to a newly characterized cytokine subset that is critical for the maintenance of mucosal homeostasis. In this review, we will summarize recent progress on the diverse functions and signals of this family of cytokines at different mucosal edges.

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“…In humans, the expression of IL-17 was found to be elevated in patients with either CD or UD compared with healthy subjects or to patients with infectious or ischaemic colitis [241][242][243]. However, CD and UC may differ in some aspects of their pathogenesis.…”

Section: Ibdmentioning

confidence: 95%

IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential

2012

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IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation, functional mechanisms and targeting strategies of IL-17 in the context of inflammatory autoimmune diseases. Evidence shows that IL-17 is highly up-regulated at sites of inflammatory tissues of autoimmune diseases and amplifies the inflammation through synergy with other cytokines, such as TNF (tumour necrosis factor) α. Although IL-17 was originally thought to be produced mainly by Th17 cells, a newly defined T-cell subset with a specific differentiation programme and tight regulation, several other cell types (especially innate immune cells) are also found as important sources for IL-17 production. Although IL-17 activates common downstream signalling, including NF-κB (nuclear factor κB), MAPKs (mitogen-activated protein kinases), C/EBPs (CCAAT/enhancer-binding proteins) and mRNA stability, the immediate receptor signalling has been shown to be quite unique and tightly regulated. Mouse genetic studies have demonstrated a critical role for IL-17 in the pathogenesis of variety of inflammatory autoimmune diseases, such as RA (rheumatoid arthritis) and MS (multiple sclerosis). Importantly, promising results have been shown in initial clinical trials of monoclonal antibodies against IL-17 or its receptor (IL-17R) to block IL-17-mediated function in treating autoimmune patients with psoriasis, RA and MS. Therefore targeting IL-17/IL-17R, IL-17-producing pathways or IL-17-mediated signalling pathways can be considered for future therapy in autoimmune diseases.

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The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease

Abstract: SummaryRecent studies have demonstrated that the complement system participates in the regulation of T cell functions. To address the local biosynthesis of complement components in inflammatory bowel disease (IBD) mucosa, we investi-

Cited by 106 publications

References 54 publications

Th17 Differentiation and Their Pro-inflammation Function

Th17 Differentiation and Their Pro-inflammation Function

The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity

IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential

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