The increased cortisol levels with preserved rhythmicity in aging and its relationship with dementia and metabolic syndrome

Martocchia, Antonio; Gallucci, Maurizio; Noale, Marianna; Maggi, Stefania; Cassol, M; Stefanelli, Manuela; Postacchini, Demetrio; Proietti, A.; Barbagallo, Mario; Domínguez, Ligia J.; Ferri, Claudio; Desideri, Giovambattista; Toussan, Lavinia; Pastore, Francesca; Falaschi, Giulia Maria; Paolisso, Giuseppe; Falaschi, P.

doi:10.1007/s40520-022-02262-1

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…(5) Mitochondrial respiration derived from the maximal respiratory capacity and in vitro force generation of types 1 and 2 fibres assessed on muscle fibres obtained from the muscle biopsy. 35 (6) Targeted metabolomics of chocolate PP and vitamin E by GC-MS and LC.…”

Section: Muscle Biopsymentioning

confidence: 99%

“…Cognitive decline and dementia are commonly linked to a decrease in muscle mass and physical function in older adults. This may be caused by an abnormal regulation of the hypothalamic–pituitary–adrenal (HPA) axis, leading to an alteration of glucose production, and the reduction in energy supply to the muscles6; the chronically elevated cortisol level7 8; and impaired energy and tissue anabolism pathways, cellular redox and reactive oxygen species (ROS) signalling, accumulatively increasing tissue degeneration in older people 9. Other possible mechanisms of tissue damage are defective modulation of genes involved in immunoinflammatory pathways causing low-grade inflammation10 and hypercortisolism 8…”

Section: Introductionmentioning

confidence: 99%

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Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age

Pedrinolla,

Isanejad,

Antognelli

et al. 2023

BMJ Open

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ObjectiveProtein–energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols (PP), in combination with muscle anabolic effect of adequate dietary protein intake and physical exercise to prevent the age-dependent decline of muscle mass and its key underpinning mechanisms including mitochondrial function, and nutrient metabolism in muscle in the elderly.Methods and analysisIn 2020, a 6-month double-blind randomised controlled trial in 75 predementia older people was launched to prevent muscle mass loss, in respond to the ‘Joint Programming Initiative A healthy diet for a healthy life’. In the run-in phase, participants will be stabilised on a protein-rich diet (0.9–1.0 g protein/kg ideal body weight/day) and physical exercise programme (high-intensity interval training specifically developed for these subjects). Subsequently, they will be randomised into three groups (1:1:1). The study arms will have a similar isocaloric diet and follow a similar physical exercise programme. Control group (n=25) will maintain the baseline diet; intervention groups will consume either 30 g/day of dark chocolate containing 500 mg total PP (corresponding to 60 mg epicatechin) and 100 mg vitamin E (as RRR-alpha-tocopherol) (n=25); or the high polyphenol chocolate without additional vitamin E (n=25). Muscle mass will be the primary endpoint. Other outcomes are neurocognitive status and previously identified biomolecular indices of frailty in predementia patients. Muscle biopsies will be collected to assess myocyte contraction and mitochondrial metabolism. Blood and plasma samples will be analysed for laboratory endpoints including nutrition metabolism and omics.Ethics and disseminationAll the ethical and regulatory approvals have been obtained by the ethical committees of the Azienda Ospedaliera Universitaria Integrata of Verona with respect to scientific content and compliance with applicable research and human subjects’ regulation. Given the broader interest of the society toward undernutrition in the elderly, we identify four main target audiences for our research activity: national and local health systems, both internal and external to the project; targeted population (the elderly); general public; and academia. These activities include scientific workshops, public health awareness campaigns, project dedicated website and publication is scientific peer-review journals.Trial registration numberNCT05343611.

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Section: Muscle Biopsymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age

Pedrinolla,

Isanejad,

Antognelli

et al. 2023

BMJ Open

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Sexuality Across Lifespan: Focus on Women’s Vulnerabilities

Graziottin,

Cuccarollo

2024

Trends in Andrology and Sexual Medicine

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Increased nocturnal urinary cortisol levels in the elderly patients with depression, coexisting major geriatric syndromes and combined pathogenetic mechanisms

Martocchia,

Stefanelli,

Gallucci

et al. 2024

Aging Clin Exp Res

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Background The mechanisms at the basis of depression are still matter of debate, but several studies in the literature suggest common pathways with dementia (genetic predispositions, metabolic and inflammatory mechanisms, neuropathological changes) and other geriatric syndromes. Aims To evaluate the role of cortisol (as marker of the HPA, hypothalamus–pituitary–adrenal axis hyperactivity) in elderly subjects with depressive symptoms (by the means of the AGICO, AGIng and COrtisol, study), in relationship to the presence of the major geriatric syndromes. Methods The AGICO study enrolled patients from ten Geriatric Units in Italy. Every subject received a comprehensive geriatric assessment or CGA (including the Mini Mental State Examination or MMSE, Geriatric Depression Scale or GDS and Cornell Scale for Depression in Dementia or CSDD), the neurological examination (with a computed tomography scan or magnetic resonance imaging of the brain), the assessment of the metabolic syndrome (MetS), the evaluation of the cortisol activity by two consecutive urine collections (diurnal and nocturnal), a CGA-derived frailty index (FI) and a modified measure of allostatic load (AL). Results The MMSE scores were significantly and inversely related to the values of GDS (p < 0.001) and CSDD (p < 0.05), respectively. The patients with depressive symptoms (GDS/CSDD > 8) showed significantly increased disability, MetS, inflammation, FI and AL and significantly reduced MMSE and renal function. The diurnal and nocturnal urinary cortisol levels in the patients with depressive symptoms (GDS/CSDD > 8) were higher with respects to controls (p < 0.05 for nocturnal difference). Discussion The AGICO study showed that the stress response is activated in the patients with depression. Conclusion The depression in elderly patient should be reconsidered as a systemic disease, with coexisting major geriatric syndromes (disability, dementia, frailty) and combined pathogenetic mechanisms (metabolic syndrome, impaired renal function, low-grade inflammation, and allostatic load). Cortisol confirmed its role as principal mediator of the aging process in both dementia and metabolic syndrome.

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The increased cortisol levels with preserved rhythmicity in aging and its relationship with dementia and metabolic syndrome

Cited by 3 publications

References 42 publications

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein–energy malnutrition in predementia aged people: study protocol for Choko-Age

Sexuality Across Lifespan: Focus on Women’s Vulnerabilities

Increased nocturnal urinary cortisol levels in the elderly patients with depression, coexisting major geriatric syndromes and combined pathogenetic mechanisms

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