The increased coexistence of autoimmune thyroiditis (AIT) in children and adolescents with thyroid carcinoma (TC) in years 2001-2015 compared to years 1996-2000

Niedziela, Marek; Flader, Maciej; Harasymczuk, Jerzy; Trejster, E; Breborowicz, D; Rabska-Pietrzak, Barbara; Kurzawa, Paweł; Bręborowicz, J

doi:10.1530/endoabs.41.ep1105

Cited by 4 publications

(4 citation statements)

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“…The co-existence of AIT and PTC ranges between 6.3 and 43% depending on the patient population and continues to rise [18, 19, 21–25]. In paediatric patients with PTC, Niedziela et al found that the prevalence of autoimmune thyroiditis increased tenfold between 1996 and 2000 and 2001–2015 [26]. Increases in both the PTC incidence and the occurrence of PTC with AIT were noted in our centre [14, 18].…”

Section: Introductionmentioning

confidence: 78%

Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

Januś

Wójcik

Taczanowska

et al. 2018

J Endocrinol Invest

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Purpose To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal changes in the thyroid gland prior to the development of PTC. Methods A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327, 12.2%) presented nodular AIT variant with a normoechogenic background. Eleven patients (11/327, 3.4%, 11/40, 27.5%) presenting this variant were diagnosed with PTC (nine females-mean age 15.3 years; two males aged 11 and 13 years). In five of 11 patients, the suspicious nodule that was later confirmed to be PTC was detected on the initial US at presentation. For the remaining six females (6/11) who developed PTC during the follow-up, we retrospectively analysed their US thyroid scans and these patients were selected for analysis in this study. Results On admission, the US evaluation revealed an enlarged normoechogenic thyroid gland in three patients and a hypoechogenic thyroid gland with fibrosis as indicated by irregular, chaotic hyperechogenic layers in three patients. No thyroid nodules were identified. Ultrasound monitoring revealed increasing echogenicity of the thyroid parenchyma during the follow-up. PTC developed in a mean time of 4.6 years (1 9/12-7 4/12 years) since referral to the outpatient thyroid clinic and 2.9 years (6/12-6 9/12) since the last nodule-free US thyroid scan. Conclusions Sonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility in the paediatric population.

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Section: Introductionmentioning

confidence: 78%

Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

Januś

Wójcik

Taczanowska

et al. 2018

J Endocrinol Invest

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“…In their study they showed that the frequency of the co-existence of PTC and AIT in 2001-2015 was 41.4%, i.e. 10 times more than in 1996-2000 [20]. In the review performed by Resende de Paiva et al, comprising 36 studies (64,628 patients from 13 countries) and published in 1955-2016, they showed the relationship between PTC and AIT.…”

Section: Casementioning

confidence: 95%

Papillary thyroid cancer in three children

Szmit-Domagalska

Horodnicka‐Józwa

Petriczko

et al. 2019

pedm

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Introduction: Thyroid cancers (TC) are rare diseases in the pediatric population and represents 0.5-3% of all malignant tumors in children. Differentiated thyroid cancer (DTC) is a major TC in children. Every patient under 18 years of age diagnosed with a thyroid nodule should undergo a detailed medical examination. The screening test for children with an increased risk for DTC is ultrasound examination of the neck. Both ultrasound and clinical images of a tissue lesion are more important than its size. It should also be emphasized that autoimmune thyroiditis (AIT), a comorbid condition for TC, is increasingly often diagnosed in young patients. Because of the rare incidence of this kind of cancer, we present 3 case studies of patients with papillary thyroid carcinoma, hospitalized in the

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“…Oh et al [ 13 ] presented that in patients with PTC, the prevalence of chronic lymphocytic thyroiditis increased fourfold in men and twofold in women between 1999 and 2008. In pediatric patients with PTC, Niedziela et al [ 14 ] found that the prevalence of chronic lymphocytic thyroiditis increased tenfold between 1996–2000 and 2001–2015 years.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development

Januś

Wójcik

Drabik

et al. 2017

J Endocrinol Invest

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Background The prevalence of autoimmune thyroiditis (AIT) and papillary thyroid carcinoma (PTC) is rising in children and adolescents, and the coincidence of AIT and PTC is as high as 6.3–43%.ObjectiveTo investigate the ultrasound manifestation of AIT in relation to PTC development in paediatric patients.Patients179 paediatric patients (133 females), mean (SD) age: 13.9 (3.03) years diagnosed with AIT and referred for ultrasound evaluation. Eight patients were diagnosed with PTC (6 females). MethodsRetrospective analysis of thyroid ultrasound scans of patients diagnosed with AIT. Thyroid and autoimmune status was assessed based on TSH, fT4, fT3 and increased aTPO and/or aTG and/or TRAB levels. In patients with PTC, total thyroidectomy was performed.ResultsAnalysis of thyroid US scans revealed that the following five ultrasound variants of AIT were observed in 179 patients: the most common in 35.2%—diffuse thyroiditis with hypoechogenic background and normoechogenic parenchyma, in 30.2%—diffuse thyroiditis with irregular background, in 18.9% nodular variant with normoechogenic background, in 11.7%—micronodulations and in 3.9%—diffuse hypoechogenic background. Eight cases of PTC were diagnosed in nodular variant of AIT with normoechogenic irregular background.ConclusionPatients with AIT and nodular variant with normoechogenic irregular background of the thyroid gland on US scans are in the risk group of developing PTC and should be followed up with regular neck US assessment.

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The increased coexistence of autoimmune thyroiditis (AIT) in children and adolescents with thyroid carcinoma (TC) in years 2001-2015 compared to years 1996-2000

Cited by 4 publications

References 0 publications

Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

Papillary thyroid cancer in three children

Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development

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