The Increase of Theta Power and Decrease of Alpha/Theta Ratio as a Manifestation of Cognitive Impairment in Parkinson’s Disease

Zawiślak-Fornagiel, Katarzyna; Ledwoń, Daniel; Bugdol, Monika; Romaniszyn-Kania, Patrycja; Małecki, Andrzej; Gorzkowska, Agnieszka; Mitas, Andrzej W.

doi:10.3390/jcm12041569

Cited by 10 publications

(7 citation statements)

References 61 publications

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“…To obtain additional insight into the effects of tau de ciency on neural activity, we also evaluated local eld potentials within the PFC by evaluating electroencephalogram (EEG) oscillations in the delta and theta bands, which are associated with cognitive and memory functions. Consistent with previous studies showing higher spectral powers in both delta and theta oscillations in patients with Alzheimer's or Parkinson's disease with dementia [59,60], we observed increased oscillation powers in both the delta and theta EEG in TKO mice relative to wild-type mice (Fig. 6G), implying that the absence of tau may have cognitive effects.…”

Section: Radiation Injury Impairs Spontaneous Ring Patterns and Spect...supporting

confidence: 92%

Subcellular functions of tau mediates repair response and synaptic homeostasis in injury

Grosshans,

Thomas,

Zhang

et al. 2024

Preprint

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Injury responses in terminally differentiated cells such as neurons is tightly regulated by pathways aiding homeostatic maintenance. Cancer patients subjected to neuronal injury in brain radiation experience cognitive declines similar to those seen in primary neurodegenerative diseases. Numerous studies have investigated the effect of radiation in proliferating cells of the brain, yet the impact in differentiated, post-mitotic neurons, especially the structural and functional alterations remain largely elusive. We identified that microtubule-associated tau is a critical player in neuronal injury response via compartmentalized functions in both repair-centric and synaptic regulatory pathways. Ionizing radiation-induced injury acutely induces increase in phosphorylated tau in the nucleus and directly interacts with histone 2AX (H2AX), a DNA damage repair (DDR) marker. Loss of tau significantly reduced H2AX after irradiation, indicating that tau may play an important role in neuronal DDR response. We also observed that loss of tau increases eukaryotic elongation factor levels after irradiation, the latter being a positive regulator of protein translation. This cascades into a significant increase in synaptic proteins, resulting in disrupted homeostasis. Consequently, novel object recognition test showed decrease in learning and memory in tau-knockout mice after irradiation, and electroencephalographic activity showed increase in delta and theta band oscillations, often seen in dementia patients. Our findings demonstrate tau’s previously undefined, multifunctional role in acute responses to injury, ranging from DDR response in the nucleus to synaptic function within a neuron. Such knowledge is vital to develop therapeutic strategies targeting neuronal injury in cognitive decline for at risk and vulnerable populations.

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Section: Radiation Injury Impairs Spontaneous Ring Patterns and Spect...supporting

confidence: 92%

Subcellular functions of tau mediates repair response and synaptic homeostasis in injury

Grosshans,

Thomas,

Zhang

et al. 2024

Preprint

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“…Meanwhile, the ATR is effective in diagnosing patients with dementia and cognitive decline (Baik et al, 2022;Jaramillo-Jimenez et al, 2021;Özbek et al, 2021;Schmidt et al, 2013;Zawiślak-Fornagiel et al, 2023); however, the results of this study suggest that depression may not be associated with this index. This difference might be attributed to a relatively lower degree of cognitive impairment in depression than in dementia.…”

Section: Discussioncontrasting

confidence: 62%

“…For instance, the alpha/beta (ABR) and theta/beta (TBR) ratios have been successfully applied to determine the degree of stress (Yi Wen & Mohd Aris, 2020 ). Meanwhile, the ATR or theta/alpha ratios can successfully differentiate patients with Alzheimer's, Parkinson's, and other Lewy body diseases from CTLs (Baik et al., 2022 ; Jaramillo‐Jimenez et al., 2021 ; Özbek et al., 2021 ; Schmidt et al., 2013 ; Zawiślak‐Fornagiel et al., 2023 ). Additionally, the TBR is useful for distinguishing Lewy body diseases from Alzheimer's disease (Baik et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Depression diagnosis based on electroencephalography power ratios

Chang

Choi

2023

Brain and Behavior

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BackgroundDepression is a common mental disorder that impacts millions of people across the world. However, its diagnosis is difficult due to the dependence on subjective testing. Although quantitative electroencephalography (EEG) has been investigated as a promising diagnostic tool for depression, the associated results have proven contradictory. The current study determines whether the alpha/beta (ABR), alpha/theta (ATR), and theta/beta (TBR) ratios can serve as biological markers of depression.MethodsWe used open‐access EEG data from OpenNeuro to investigate power ratios in the resting state of 46 patients with depression and 75 healthy controls. Spectral data were extracted by fast Fourier transform at the theta band (4–8 Hz), alpha band (8–13 Hz), and beta band (13–32 Hz). Neural network, logistic regression, and receiver operating characteristic (ROC) curves were used to assess the diagnostic accuracies of each suggested index. Additionally, the cutoff point, sensitivity, specificity, positive predictive value, and negative predictive value at the maximized Youden index were compared for each variable.ResultsDecreased anterior frontal, frontal, central, parietal, occipital, and temporal ABR and decreased central and parietal TBR were observed in the depression group. The area under the curve of the ROC curves further revealed that these ratios could all effectively differentiate depression. In particular, the central, frontal, and parietal ABR exhibited high discrimination scores. Multiple logistic regression analysis demonstrated that the Beck Depression Inventory and Spielberger Trait Anxiety Inventory scores, as well as the probability of depression, increased with a decrease in the central ABR. Moreover, neural network analysis revealed that the global ABR was the most effective index for diagnosing depression among the three global EEG power ratios.ConclusionsThe central, frontal, and parietal ABR represent potential biomarkers to differentiate patients with depression from healthy controls.

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“…In addition, the spectral ratios between frequency bands can be used to successfully evaluate cognition and detect dementia, including Alzheimer's disease, Parkinson's disease, and Lewy body dementia [23][24][25][26][27][28]. However, the EEG spectral ratios of frontal frequency power/temporal frequency power have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Electroencephalography Markers for an Accurate Diagnosis of Frontotemporal Dementia: A Spectral Power Ratio Approach

Chang,

Chang

2023

Medicina

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Background and Objectives: Frontotemporal dementia (FTD) is the second most common form of presenile dementia; however, its diagnosis has been poorly investigated. Previous attempts to diagnose FTD using quantitative electroencephalography (qEEG) have yielded inconsistent results in both spectral and functional connectivity analyses. This study aimed to introduce an accurate qEEG marker that could be used to diagnose FTD and other neurological abnormalities. Materials and Methods: We used open-access electroencephalography data from OpenNeuro to investigate the power ratio between the frontal and temporal lobes in the resting state of 23 patients with FTD and 29 healthy controls. Spectral data were extracted using a fast Fourier transform in the delta (0.5 ≤ 4 Hz), theta (4 ≤ 8 Hz), alpha (8–13 Hz), beta (>13–30 Hz), and gamma (>30–45 Hz) bands. Results: We found that the spectral power ratio between the frontal and temporal lobes is a promising qEEG marker of FTD. Frontal (F)-theta/temporal (T)-alpha, F-alpha/T-theta, F-theta/F-alpha, and T-beta/T-gamma showed a consistently high discrimination score for the diagnosis of FTD for different parameters and referencing methods. Conclusions: The study findings can serve as reference for future research focused on diagnosing FTD and other neurological anomalies.

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The Increase of Theta Power and Decrease of Alpha/Theta Ratio as a Manifestation of Cognitive Impairment in Parkinson’s Disease

Cited by 10 publications

References 61 publications

Subcellular functions of tau mediates repair response and synaptic homeostasis in injury

Subcellular functions of tau mediates repair response and synaptic homeostasis in injury

Depression diagnosis based on electroencephalography power ratios

Quantitative Electroencephalography Markers for an Accurate Diagnosis of Frontotemporal Dementia: A Spectral Power Ratio Approach

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