The increase in the proportion of nervous animals bred for catatonia: The participation of central adrenoreceptors in catatonic reactions

Ryazanova, M. A.; Igonina, T. N.; Алехина, Т. А.; Prokudina, O. I.

doi:10.1134/s1022795412100092

Cited by 8 publications

(9 citation statements)

References 13 publications

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“…Moreover, the same rat could react with either freezing or hyperexcitation responses during consecutive tests. This observation confirms the validity of GC rats as an adequate model of catatonia because the same symptoms are observed in patients with Although the selection was performed to enhance cataleptic freezing, individuals appeared in the population of the selected rats in which hyperkinetic reactions predominated, i.e., an increased defensive reaction, nondirectional locomotor agitation, and vocaliza-tion [85,86]. Moreover, the same rat could react with either freezing or hyperexcitation responses during consecutive tests.…”

Section: A Short History Of the Gc Rat Strainsupporting

confidence: 73%

“…A rat was considered to be cataleptic if it kept the given posture for at least 10 s in three out of five trials [84]. Although the selection was performed to enhance cataleptic freezing, individuals appeared in the population of the selected rats in which hyperkinetic reactions predominated, i.e., an increased defensive reaction, nondirectional locomotor agitation, and vocalization [85,86]. Moreover, the same rat could react with either freezing or hyperexcitation responses during consecutive tests.…”

Section: A Short History Of the Gc Rat Strainmentioning

confidence: 99%

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Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Ryazanova,

Plekanchuk,

Prokudina

et al. 2023

Biomedicines

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Research into genetic and physiological mechanisms of widespread disorders such as arterial hypertension as well as neuropsychiatric and other human diseases is urgently needed in academic and practical medicine and in the field of biology. Nevertheless, such studies have many limitations and pose difficulties that can be overcome by using animal models. To date, for the purposes of creating animal models of human pathologies, several approaches have been used: pharmacological/chemical intervention; surgical procedures; genetic technologies for creating transgenic animals, knockouts, or knockdowns; and breeding. Although some of these approaches are good for certain research aims, they have many drawbacks, the greatest being a strong perturbation (in a biological system) that, along with the expected effect, exerts side effects in the study. Therefore, for investigating the pathogenesis of a disease, models obtained using genetic selection for a target trait are of high value as this approach allows for the creation of a model with a “natural” manifestation of the pathology. In this review, three rat models are described: ISIAH rats (arterial hypertension), GC rats (catatonia), and PM rats (audiogenic epilepsy), which are developed by breeding in the Laboratory of Evolutionary Genetics at the Institute of Cytology and Genetics (the Siberian Branch of the Russian Academy of Sciences).

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Section: A Short History Of the Gc Rat Strainsupporting

confidence: 73%

Section: A Short History Of the Gc Rat Strainmentioning

confidence: 99%

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Ryazanova,

Plekanchuk,

Prokudina

et al. 2023

Biomedicines

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“…The strains were obtained by selection for intensification of such catatonic reactions as freezing or catalepsy (GC strain) and stereotyped pendulum movements (PM strain). The GC rats demonstrate occasional freezing or, instead, hyperkinetic behavioral reactions that resemble the manifestations of the catatonic syndrome (Ryazanova et al, 2012). These reactions can be spontaneous, as well as in response to a weak stressful stimulus, such as in a special test for catatonic freezing (Fig.…”

Section: Introductionmentioning

confidence: 98%

Social behavior and spatial orientation in rat strains with genetic predisposition to catatonia (GC) and stereotypes (PM)

2022

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Various psychopathologies, including schizophrenia, bipolar disorder and major depression, are associated with abnormalities in social behavior and learning. One of the syndromes that may also take place in these disorders is catatonia. Catatonia is a psychomotor syndrome in which motor excitement, stereotypy, stuporous state, including the phenomenon of “waxy flexibility” (catalepsy), can be observed. Rats with genetic catatonia (GC) and pendulum-like movements (PM) of the anterior half of the body have physiological and behavioral changes similar to those observed in schizophrenia and depression in humans and can be considered as incomplete experimental models of these pathologies. The social behavior of the GC and PM rats has not been previously studied, and the cognitive abilities of animals of these strains are also insufficiently studied. To determine whether the GC and PM rats have changes in social behavior and spatial learning, behavioral phenotyping was performed in the residentintruder test, three-chamber test, Barnes maze test. Some deviations in social behavior, such as increased offensive aggression in PM rats in the resident-intruder test, increased or decreased social interactions depending on the environment in different tests in GC, were shown. In addition, principal component analysis revealed a negative association between catatonic freezing and the socialization index in the three-chamber test. Decreased locomotor activity of GС rats can adversely affect the performance of tasks on spatial memory. It has been shown that PM rats do not use a spatial strategy in the Barnes maze, which may indicate impairment of learning and spatial memory.

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“…GC animals exhibit all range of catatonic reactions (from catatonic stupor to catatonic excitation). Hyperkinetic behavior of these rats refl ects the state of increased nervous excitability [1,2,5]. The signs of insuffi ciency and destabilization of reproductive functions were previously revealed in GC females with catatonic deviations [3,4].…”

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confidence: 94%

Synchronization of the Estrous Cycle against the Background of Increased Excitability in Rats Selected for Catatonic Type of Reaction

et al. 2015

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Selection for the elevation of catatonic type of reaction in female GC rats ("genetic" and "catatonia") was followed by an increase in the number of intense running episodes in response to acoustic stimulation. The observed changes are typical of increased general excitability in these animals. The phenomenon of estrous cycle synchronization was confirmed by variations in the concentrations of estradiol and progesterone in groups of Wistar and GC rats differing by the degree of synchronization. Some differences were found in the concentration of main sex hormones in the blood from female GC and Wistar rats.

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The increase in the proportion of nervous animals bred for catatonia: The participation of central adrenoreceptors in catatonic reactions

Cited by 8 publications

References 13 publications

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by Breeding

Social behavior and spatial orientation in rat strains with genetic predisposition to catatonia (GC) and stereotypes (PM)

Synchronization of the Estrous Cycle against the Background of Increased Excitability in Rats Selected for Catatonic Type of Reaction

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