The Increase in Serum Visfatin After Bariatric Surgery in Morbidly Obese Women is Modulated by Weight Loss, Waist Circumference, and Presence or Absence of Diabetes Before Surgery

Botella-Carretero, José I.; Luque‐Ramírez, Manuel; Álvarez‐Blasco, Francisco; Peromingo, Roberto; Millán, José L. San; Escobar-Morreale, Héctor F.

doi:10.1007/s11695-007-9369-7

Cited by 29 publications

(20 citation statements)

References 39 publications

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“…However, its levels did not correlate with weight loss. This supports other authors' observations that visfatin levels tend to be increased with weight loss [9,14]. We found a positive correlation of its levels with the adiponectin and omentin levels before and after therapy.…”

Section: Discussionsupporting

confidence: 92%

“…However, data are conflicting [6,9,14,15,25]. Visfatin is produced by visceral adipose tissue and is known as a pre-B cell colonyenhancing factor that mediates inflammatory response by induction of Il-6 and TNF-a, but its higher concentration augments the expression of anti-inflammatory cytokines such as Il-10 [6,9,27].…”

Section: Discussionmentioning

confidence: 99%

“…Despite studies showing that bariatric therapies decrease body weight, improve insulin resistance and glucose metabolism, and may reduce inflammation, the exact mechanism is not well understood [1,[9][10][11][12]. Several reports have described different plasma hormonal changes after bariatric surgery, but the data on the effect on the omentin and visfatin levels are sparse and conflicting [9][10][11][12][13][14][15][16][17]. Moreover, only a few studies have described hormonal changes, mainly ghrelin and leptin, after endoscopic placement of a balloon into the stomach (bioenterics intragastric balloon, BIB), which is a commonly used procedure, also as bridge therapy to surgery, due to its minimal invasiveness and good tolerability [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Variation in blood levels of hormones in obese patients following weight reduction induced by endoscopic and surgical bariatric therapies

et al. 2016

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Variation in blood levels of hormones in obese patients following weight reduction induced by endoscopic and surgical bariatric therapies

et al. 2016

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“…All samples were run in duplicate with quality controls, and inter- and intra-assay coefficients of variation for all analytes were <15%. In routine evaluation in our laboratory, as well as previously published data (21–24), suggest that long-term storage and freezing/thawing does not affect levels of the molecules of interest.…”

Section: Methodssupporting

confidence: 78%

Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans

Kang

Magkos

Sienkiewicz

et al. 2011

European Journal of Endocrinology

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Objective Animal and in vitro studies indicate that leptin alleviates starvation-induced reduction in circulating vaspin and stimulates the production of visfatin. We thus examined whether vaspin and visfatin are affected by short- and long-term energy deprivation and leptin administration in human subjects in vivo. Design and Methods We measured circulating levels of vaspin and visfatin 1) before and after 72-h of starvation (leading to severe hypoleptinemia) with or without leptin administration in replacement doses in 13 normal-weight subjects, 2) before and after 72-h of starvation with leptin administration in pharmacological doses in 13 lean and obese subjects, 3) during chronic energy deficiency in 8 women with hypothalamic amenorrhea on leptin replacement for 3 months, and 4) during chronic energy deficiency in 18 women with hypothalamic amenorrhea on leptin replacement or placebo for 3 months. Results Acute starvation decreased serum leptin (to 21% of baseline values, P=0.002) but had no significant effect on vaspin and visfatin concentrations (P>0.05). Nor did normalization of leptin levels affect the concentrations of these two adipokines (P>0.9). Leptin replacement in women with hypothalamic amenorrhea did not significantly alter vaspin and visfatin concentrations, whether relative to baseline (P>0.15) or relative to placebo administration (P>0.9). Pharmacological doses of leptin did not affect circulating vaspin and visfatin concentrations (P>0.9). Conclusions Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte-secreted hormonal regulators of metabolism are independently regulated in humans.

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“…All samples were run in duplicate with quality controls, and interand intra-assay coefficients of variation for all analytes were <15%. In routine evaluation in our laboratory, as well as previously published data (21)(22)(23)(24), suggest that long-term storage and freezing/thawing does not affect levels of the molecules of interest.…”

Section: Hormone Measurementssupporting

confidence: 74%

Circulating Vaspin and Visfatin Are Not Affected by Acute or Chronic Energy Deficiency or Leptin Administration in Humans

Kang¹,

Magkos²,

Sienkiewicz³

et al. 2011

BASIC/TRANSLATIONAL - Hypothalamic Signaling in Feeding Behavior &Amp; Metabolic Regulation

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Objective-Animal and in vitro studies indicate that leptin alleviates starvation-induced reduction in circulating vaspin and stimulates the production of visfatin. We thus examined whether vaspin and visfatin are affected by short-and long-term energy deprivation and leptin administration in human subjects in vivo.Design and Methods-We measured circulating levels of vaspin and visfatin 1) before and after 72-h of starvation (leading to severe hypoleptinemia) with or without leptin administration in replacement doses in 13 normal-weight subjects, 2) before and after 72-h of starvation with leptin administration in pharmacological doses in 13 lean and obese subjects, 3) during chronic energy deficiency in 8 women with hypothalamic amenorrhea on leptin replacement for 3 months, and 4) during chronic energy deficiency in 18 women with hypothalamic amenorrhea on leptin replacement or placebo for 3 months.Results-Acute starvation decreased serum leptin (to 21% of baseline values, P=0.002) but had no significant effect on vaspin and visfatin concentrations (P>0.05). Nor did normalization of leptin levels affect the concentrations of these two adipokines (P>0.9). Leptin replacement in women with hypothalamic amenorrhea did not significantly alter vaspin and visfatin concentrations, whether relative to baseline (P>0.15) or relative to placebo administration (P>0.9). Pharmacological doses of leptin did not affect circulating vaspin and visfatin concentrations (P>0.9).Conclusions-Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte-secreted hormonal regulators of metabolism are independently regulated in humans.

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The Increase in Serum Visfatin After Bariatric Surgery in Morbidly Obese Women is Modulated by Weight Loss, Waist Circumference, and Presence or Absence of Diabetes Before Surgery

Abstract: Serum visfatin increased after bariatric surgery in relation to the amount of weight lost and to the changes in waist circumference, and this increase was higher in diabetic patients.

Cited by 29 publications

References 39 publications

Variation in blood levels of hormones in obese patients following weight reduction induced by endoscopic and surgical bariatric therapies

Variation in blood levels of hormones in obese patients following weight reduction induced by endoscopic and surgical bariatric therapies

Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans

Circulating Vaspin and Visfatin Are Not Affected by Acute or Chronic Energy Deficiency or Leptin Administration in Humans

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