The increase in immunosuppression and its role in the development of malignant lesions

Cole, Warren H.

doi:10.1002/jso.2930300303

Cited by 36 publications

(3 citation statements)

References 21 publications

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“…Han et al [19] suggested that laparoscopic colorectal surgery at clinical stage III had an immunological advantage of preserved mhuman leukocyte antigen (HLA)-DR on postoperative day 5 even though oncologic benefit was not shown in those patients. Several reports have suggested a critical role for immunity in tumor progression and metastasis [20,21]. Further studies on the immunologic benefits are needed to draw a definitive conclusion regarding the benefits of LS.…”

Section: Discussionmentioning

confidence: 99%

Comparison of long-term oncologic outcomes of stage III colorectal cancer following laparoscopic versus open surgery

2015

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PurposeThe oncologic outcomes after performing laparoscopic surgery (LS) compared to open surgery (OS) are still under debate and a concern when treating patients with colon cancer. The aim of this study was to compare the long-term oncologic outcomes of LS and OS as treatment for stage III colorectal cancer patients.MethodsFrom January 2001 to December 2007, 230 patients with stage III colorectal cancer who had undergone LS or OS in this single center were assessed. Data were analyzed according to intention-to-treat. The primary endpoints were disease-free survival and overall survival.ResultsA total of 230 patients were entered into the study (114 patients had colon cancer-33 underwent LS and 81 underwent OS; 116 patients had rectal cancer-44 underwent LS and 72 underwent OS). The median follow-up periods for the colon and rectal cancer groups were 54 and 53 months, respectively. The overall conversion rate was 12.1% (n = 4) for colon cancer, and 4.5% (n = 2) for rectal cancer. Disease-free 5-year survival of colon cancer was 84.3% and 90% in LS group (LG) and OS group (OG), respectively, and that of rectal cancer was 83% and 74.6%, respectively (P > 0.05). Overall 5-year survival for colon cancer was 72.2% and 71.3% for LG and OG, respectively, and that for rectal cancer was 67.6% and 59.2%, respectively (P > 0.05).ConclusionThe long-term analyses for oncologic aspects of our study may confirm the safety of LS compared to OS in stage III colorectal cancer patients.

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Section: Discussionmentioning

confidence: 99%

Comparison of long-term oncologic outcomes of stage III colorectal cancer following laparoscopic versus open surgery

2015

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“…Tumor immunity, mainly defined as the cellular immune responses in the body against tumor, is believed to be critical for defense against cancer cells, especially during surgical interventions in CRC patients [33, 34]. The cellular immunity is mainly related to the function of antigen-presenting cells, including macrophages and dendritic cells which present tumor antigens and stimulate Th1 cells.…”

Section: Cellular Immunitymentioning

confidence: 99%

Immune response after laparoscopic colectomy for cancer: a review

Karanika

Karantanos

Theodoropoulos

2013

Gastroenterology Report

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Background and aim: Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide and laparoscopic colectomy has been established as equivalent to the open approach in terms of oncological results and patients’ safety. Survival benefits have been reported in favor of laparoscopic colectomy (LC) in stage III CRC patients. Different immune responses after surgery, in terms of innate and cellular immunity, may potentially explain some of the reported differences. This review summarizes the literature on differences in immune response after the laparoscopic and the open approach for CRC.Materials and Methods: A literature search of electronic databases was conducted and all studies published on ‘colorectal cancer’, ‘laparoscopic and open colectomy’ ‘immune response’ and ‘surgical stress laparoscopy versus open’ were collected. Among these, the ones referring to CRC and those that had any clinical relevance offering information on perioperative parameters were used.Results: Despite the heterogeneity of studies, they support the view that innate immune response is activated to a greater degree in open colectomy (OC), which may be related to the more extensive trauma and surgical stress. On the other hand, cellular immunity is better preserved after LC. These differences are more pronounced in the immediate postoperative period.Conclusions: LC has been related to decreased up-regulation of innate immunity and better-preserved cellular immunity. The latter may be related to better anti-tumor activity and may be beneficial in terms of oncological survival in a subgroup of LC patients.

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“…Successful outcomes of solid organ transplantation can be achieved by applying strong immunosuppressive drugs that are expected to decrease the incidence of acute graft rejection ( 6 ). Notably, solid organ transplant recipients under such treatment are at a higher risk of developing certain malignancies compared with the general population ( 7 ). The long duration of immunosuppression in solid organ recipients impairs the immunosurveillance of the body and results in the outgrowth of neoplastic cells ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

No significant association between immunosuppression in solid organ transplantation and prostate cancer risk: a meta-analysis of cohort studies

Bao¹,

Zhu²,

Yang³

et al. 2019

Transl. Cancer Res

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Background It is known that organ transplant recipients have a significantly higher risk for developing cancers, but the association between immunosuppression in organ transplantation and the risk for prostate cancer (PCa) remains unclear. We aimed to assess the evidence regarding the association of solid organ transplantation with PCa risk. Methods A literature search of the PubMed, Embase, and Web of Science databases was performed up to March 2019. Combined relative risks (RRs) and 95% confidence intervals (CIs) were calculated by using a fixed-effect or random-effect model. Results In total, 26 articles including 33 independent population-based cohort studies with 556,812 recipients and 2,438 PCa cases were identified and included in this meta-analysis. PCa risk in the solid organ transplant recipients did not increase compared with the general population (RR=1.04; 95% CI: 0.90–1.18). Independent analysis of different kinds of organ replacements further indicated immune inhibition in the transplantation of kidney, liver, heart, and lung, and was not associated with elevated PCa risk (RR=0.89; 95% CI: 0.83–0.95; RR=0.61, 95% CI: 0.21–1.02; RR=1.70, 95% CI: 0.88–2.52; RR=0.87, 95% CI: 0.57–1.16, respectively). Conclusions This study demonstrated that immunosuppression in solid organ transplant recipients was not associated with higher PCa risk.

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The increase in immunosuppression and its role in the development of malignant lesions

Cited by 36 publications

References 21 publications

Comparison of long-term oncologic outcomes of stage III colorectal cancer following laparoscopic versus open surgery

Comparison of long-term oncologic outcomes of stage III colorectal cancer following laparoscopic versus open surgery

Immune response after laparoscopic colectomy for cancer: a review

No significant association between immunosuppression in solid organ transplantation and prostate cancer risk: a meta-analysis of cohort studies

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