The incorporation of drug molecules with poor water solubility into polypyrrole as dopants: Indomethacin and sulindac

Ryan, Eimear M.; Breslin, Carmel B.

doi:10.1016/j.electacta.2018.11.107

Cited by 14 publications

(9 citation statements)

References 24 publications

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“…As expected, a potential increase from 1 to 1.2 V (vs. Ag quasiref.) produces an increase in the charge required for anodic polymerization, in agreement with [45,46]. The recorded current-time plots at constant applied potentials showed a relatively similar behavior for the two investigated alloys.…”

Section: Electrochemical Preparation Of Ppy and Of The Ppy-indo Coatings Using Des Based Electrolytessupporting

confidence: 79%

“…The polymerization charge obtained for different Indo concentrations in the ILM-ACN based electrolytes is summarized in Table 2. Usually, from the gradient of the charge-time plot, the rate of polymer deposition can be estimated and any deviation from the linear trend would suggest a loss in the conductivity of the deposited polymer [46]. Therefore, rates of electrochemical polymerization were calculated for the investigated Indo doped PPy coatings, ranging between 2.16 and 3.54 mC s −1 (1.44-2.36 mC cm -2 s −1 ) and 2.0-4.83 mC s −1 (1.3-3.22 mC cm −2 s −1 ) for IB and ND substrates, respectively.…”

Section: Electrochemical Preparation Of Ppy and Of The Ppy-indo Coatings Using Des Based Electrolytesmentioning

confidence: 99%

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Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

Golgovici

Cârlan

Popescu

et al. 2020

Metals

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There is an increased interest in the use of the deep eutectic solvents (DESs) as electrolytic media for electrochemical synthesis of conducting polymers, which could influence their characteristics. Moreover, the polypyrrole layers represent an attractive route for pharmaceutical drug release. The paper presents several experimental results regarding the electrodeposition of polypyrrole and of polypyrrole-indomethacin coatings on nickel-chromium NiCr alloy substrates widely used in dentistry, involving DES-based electrolytes, namely eutectic mixtures of choline chloride and malonic acid. This type of electrolyte also allowed an enhanced dissolution of indomethacin as compared to aqueous ones. The electropolymerization process has been investigated by cyclic voltammetry and chronoamperometry. The obtained indomethacin containing polymeric coatings have been thoroughly characterized involving scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, contact angle measurements in simulated body fluid (SBF) and indomethacin release studies. Adherent and uniform polypyrrole-indomethacin layers have been obtained on NiCr alloy substrates. The release tests showed that the polypyrrole coatings containing indomethacin may deliver the drug molecules for longer periods of at least 17 days. The maximum released amount was around 99.6% suggesting these layers may act as an active reservoir for indomethacin. Kinetics analysis based on the Korsmeyer–Peppas model suggested the diffusion of the drug out of the polymer layer as the most probable mechanism governing the release.

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Section: Electrochemical Preparation Of Ppy and Of The Ppy-indo Coatings Using Des Based Electrolytessupporting

confidence: 79%

Section: Electrochemical Preparation Of Ppy and Of The Ppy-indo Coatings Using Des Based Electrolytesmentioning

confidence: 99%

Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

Golgovici

Cârlan

Popescu

et al. 2020

Metals

View full text Add to dashboard Cite

show abstract

“…Conducting polymers, and in particular polypyrrole, have been considered and investigated as membranes for the controlled delivery of drugs [1][2][3][4][5][6][7]. In addition to exhibiting biocompatible properties, polypyrrole films are responsive and they can be stimulated to uptake and release ions.…”

Section: Introductionmentioning

confidence: 99%

“…This uptake and release which maintains charge neutrality is associated with the redox switching between the oxidised and the reduced states, where the polymer backbone is positively charged when oxidised and neutral when reduced. A number of studies has been reported describing the uptake and release of anionic drug molecules [1][2][3][4][5]. During electrochemical polymerisation, the anionic drug molecules are incorporated into the polymer film as dopants to compensate the positive charge on the oxidised polypyrrole.…”

Section: Introductionmentioning

confidence: 99%

“…This makes these nanogel materials interesting in terms of delivery to cancer cells. While polypyrrole is responsive to pH changes and reducing agents, electrical stimulation is normally used to release molecules from the polypyrrole films [4,6]. However, polypyrrole is particularly suited to transdermal drug delivery applications, as an implant or as a scaffold material.…”

Section: Introductionmentioning

confidence: 99%

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The incorporation and controlled release of dopamine from a sulfonated β–cyclodextrin–doped conducting polymer

Hendy

Breslin

2019

J Polym Res

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Pyrrole was electropolymerised in the presence of sulfonated β-cyclodextrin to give a conducting polypyrrole film doped with the anionic cyclodextrin, PPy-sβ-CD. On reduction of the polymer film at −0.80 V vs SCE, high concentrations of dopamine (DA) were incorporated and the DA was subsequently released at a potential of 0.10 V vs SCE. Much higher levels of DA were incorporated and released at PPy-sβ-CD compared to polypyrrole films doped with smaller anions and doped with the larger para-toluene sulfonic acid. In addition to releasing higher concentrations of DA, the DA was less prone to oxidation and degradation in the presence of the sulfonated β-cyclodextrin. This was attributed to the formation of an inclusion complex between the protonated DA molecule and the anionic CD. The higher release rates were explained in terms of the immobile nature of the large CD and the high charge density with approximately 9 sulfonated groups attached to the rim of the CD cavity, which facilitated the uptake of high levels of DA. Approximately 6.0 μmol cm −2 of DA was released at 0.10 V vs SCE over 60 min on reducing the PPy-sβ-CD film for 30 min at −0.80 V vs SCE. Higher levels of 9.6 μmol cm −2 were obtained on increasing the reduction period to 60 min, while levels of 14.0 μmol cm −2 were achieved with thicker polymer films.

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Conducting Polymers as Drug Release Systems

Smith

2023

Advanced Clinical Pharmacy - Research, Development and Practical Applications

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The incorporation of drug molecules with poor water solubility into polypyrrole as dopants: Indomethacin and sulindac

Cited by 14 publications

References 24 publications

Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

Electrochemical Synthesis of Polypyrrole and Polypyrrole-Indomethacin Coatings on NiCr Alloys Involving Deep Eutectic Solvents

The incorporation and controlled release of dopamine from a sulfonated β–cyclodextrin–doped conducting polymer

Conducting Polymers as Drug Release Systems

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