1987
DOI: 10.1016/0014-4827(87)90023-1
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The incorporation of deoxyuridine monophosphate into DNA increases the sister-chromatid exchange yield

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1987
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Cited by 14 publications
(3 citation statements)
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“…It was confirmed that the SCE method using the incorporation of the 5-bromodeoxyuridine (BrdU) in combination with 2′deoxyuridine (dUrd) and 5-fluoro-2′-deoxyuridine (FdU) increases the sister chromatid exchange yield (Pardo et al, 1987). The application of BrdU can cause a distortion of the chromosome morphology, a lower proportion of metaphase cells per slide, and problems with poor sister chromatid differentiation as a result of an incorrect BrdU concentration (Gerster and Grant, 1989).…”
Section: Discussionmentioning
confidence: 95%
“…It was confirmed that the SCE method using the incorporation of the 5-bromodeoxyuridine (BrdU) in combination with 2′deoxyuridine (dUrd) and 5-fluoro-2′-deoxyuridine (FdU) increases the sister chromatid exchange yield (Pardo et al, 1987). The application of BrdU can cause a distortion of the chromosome morphology, a lower proportion of metaphase cells per slide, and problems with poor sister chromatid differentiation as a result of an incorrect BrdU concentration (Gerster and Grant, 1989).…”
Section: Discussionmentioning
confidence: 95%
“…This was virtually a black box, although it was known that replicative forms of geminiviruses were abundant in S-phase cells [ 24 ]. This side of the original project had deep roots into (i) my early work of cell proliferation kinetics and DNA repair in Allium cepa meristems [ 25 , 26 , 27 , 28 , 29 ], and (ii) my previous experience with SV40 T-ag interactions with the host cell. The identification in 1987 of the human homolog of the yeast p34Cdc2 protein [ 30 ], the main cyclin-dependent kinase (CDK) active during the cell cycle triggered the interest in several laboratories to ask whether plant cells would have a similar protein.…”
Section: Early Studiesmentioning
confidence: 99%
“…However, successfull attempts have beet? made to determine the presence of uracil in DNA both in animal (Richards et al, 1984) and plant cells (Pardo et a!, 1987),…”
Section: Introductionmentioning
confidence: 99%