The incidence rates of endometrial hyperplasia and endometrial cancer: a four-year population-based study

Yuk, Jin‐Sung

doi:10.7717/peerj.2374

Cited by 12 publications

(12 citation statements)

References 20 publications

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“…It is estimated, however, that the incidence of endometrial hyperplasia is at least three times higher than endometrial cancer. Current estimates report incidence of endometrial hyperplasia to be around 133-208 per 100,000 woman-years in Western countries [3] and 37/100,000 woman-years in Korea [12]. The incidence rates of the endometrial hyperplasia subtypes are 121 per 100,000 woman-years for non-atypical hyperplasia and 16.8 per 100,000 woman-years for atypical hyperplasia [3,13].…”

Section: Introductionmentioning

confidence: 99%

The value of MRI in management of endometrial hyperplasia with atypia

et al. 2020

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Background: The value of the magnetic resonance imaging (MRI) in the assessment of women with endometrial hyperplasia and its role in diagnosis of myometrial invasion or coexistence of cancer is not known. This study aimed to evaluate the accuracy and usefulness of MRI in the management of patients diagnosed on endometrial biopsy with complex endometrial hyperplasia with atypia (CEHA). Methods: A retrospective study of 86 cases diagnosed with endometrial hyperplasia with atypia on the initial endometrial biopsy in a tertiary university teaching hospital between 2010 and 2015 was carried out. The MRI accuracy in predicting malignant changes and influence the clinical management was compared among women who had either pelvic MRI, transvaginal ultrasound (TVUS), or no additional imagistic studies. Results: MRI was performed in 24 (28%) and TVUS in 11 (13%)cases, while 51 (59%) women had no additional imagistic studies. In the group of women with no imaging studies, 26/51 (51%) were surgically treated and 8/26 (31%) were diagnosed with endometrial cancer (EEC) stage 1a. In the group of women who had TVUS, 5/11 (45%) were surgically treated and none was diagnosed with EEC. In the group of women who underwent an MRI examination, 20/24 (83%) were surgically treated. Among these, 11/20 (55%) were diagnosed with EEC, 7 had EEC stage 1a, and 4 had EEC stage 1b. Although MRI was able to identify malignant changes with a good sensitivity (91.7%), it had a low specificity in characterisation of malignant transformation (8%). MRI correctly identified 31% of the stage 1a and 33% of the stage 1b endometrial cancer. Conclusion: In this study, we found a potential diagnostic value of MRI for identifying malignant transformation in patients with CEHA. However, pelvic MRI has a rather weak predictive value of myometrial invasion in women with CEHA and concurrent EEC. The diagnostic and therapeutic benefits of MRI assessment in patients with CEHA need further validation.

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Section: Introductionmentioning

confidence: 99%

The value of MRI in management of endometrial hyperplasia with atypia

et al. 2020

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“…The peak incidence of age at diagnosis was between; 55 to 64 years, the same as in Korea [20], Taiwan [21] and Turkey [23], but lower than Romania [22], and Tunisia [26]. The peak incidence in these age groups was mainly in postmenopausal women, and the year of birth was between; 1945 and 1960 (Fig.…”

Section: Discussionmentioning

confidence: 90%

“…5) [19]. The ASR of endometrial cancer, from a population-based study in the Songkhla Province, was lower than in Korea [20] Taiwan [21], Romania [22], Turkey [23], Croatia [24], and Netherland [25], which were 7.0, 7.5, 8.2, 10.4, 11.4, and 20.1 per 100,000 women-years, respectively, but higher than in; Tunisia [26] and mainland China [27], which were 3.1 and 5.0 per 100,000 women-years, respectively. The annual percentage change of uterine cancer within the Songkhla Province was; 4.6% per year, which was lower than Tunisia [26] (7.1% per year), but higher than Turkey [23] and the Netherlands [25] (2.4% and 3.4% per year, respectively).…”

Section: Discussionmentioning

confidence: 99%

Trends in incidence of uterine cancer in Songkhla, Southern Thailand

et al. 2019

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Objective To define the present incidence of uterine cancer and the trends of incidence in the future. Additional, subgroup analysis in religion and socio-demographic factors will be analyzed. Methods The data of uterine cancer from The Songkhla Cancer Registry between; 1989 and 2016, was extracted. The population denominators of Songkhla Province were referred from the information of the population censuses surveyed by the National Statistical Office. The incidence was estimate by; the age specific rate, and analyzed in trend incidence using Jointpoint and Age-period-cohort; APC regression models and trend projection in 2017–2030 using by Jointpoint, the NordPred and APC model. The comparison of incidence according to habitat and religion were unpaired t-test. Results The incidence of uterine cancer in Songkhla Province increased from 1.5, to 5.3 per 100,000 women-years in 2016, and 8 per 100,000 women-years in 2030. The incidence was more in urban areas and in Buddhists. Conclusion The incidence of uterine cancer is increasing. The policy, which promotes protective factors and control risk factors, would decrease incidence of endometrial cancer, and other estrogen dependent cancers additional to chronic diseases from the cardiovascular system.

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“…From the histopathological findings, D&C revealed 3.1% of endometrial hyperplasia and 1.6% of endometrial cancer in patients. In reproductive‐aged women, the total incidence of endometrial hyperplasia and cancer is <0.1% 29,30 ; therefore, antibiotic‐ineffective CE must be a risk factor for endometrial cancer. A chronic inflammation‐mediated condition triggers the onset of neoplastic transformation and the development of cancer in the female reproductive tract 31,32 .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of gentle endometrial curettage on antibiotic‐resistant chronic endometritis in infertile women

Kuroda

Ishiyama²,

Shiobara³

et al. 2023

Reprod Medicine & Biology

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PurposeTo identify the efficacy of endometrial curettage on antibiotic‐resistant chronic endometritis (CE) in infertile women.MethodsOf 1580 women with CE, 87 with antibiotic‐resistant CE after two to five cycles of antibiotic treatment were recruited between 2019 and 2021. The women who underwent endometrial curettage without applying any force and, in the subsequent menstrual cycle, endometrial sampling for CD138 immunostaining without antibiotic use. Pregnancy outcomes after in vitro fertilization treatment were analyzed in women who did not desire endometrial curettage and in those with cured and persistent CE after endometrial curettage.ResultsIn 64 women who underwent endometrial curettage, the number of CD138‐positive cells decreased from 28.0 ± 35.3 to 7.7 ± 14.0 (p < 0.0001), and CE in 41 women (64.1%) was cured (<5 CD138‐positive cells). The pathological findings detected 3.1% of endometrial hyperplasia and 1.6% of endometrial cancer. The ongoing pregnancy rates in women aged ≤42 without endometrial curettage were significantly lower than those of women with cured and persistent CE (26.7%, 67.6%, and 57.1%, respectively, p = 0.03).ConclusionsGentle endometrial curettage for antibiotic‐resistant CE significantly decreased the number of CD138‐positive cells, resulting in improved pregnancy outcomes regardless of remaining CE. Endometrial curettage is also important as a screening for endometrial malignancy.

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The incidence rates of endometrial hyperplasia and endometrial cancer: a four-year population-based study

Cited by 12 publications

References 20 publications

The value of MRI in management of endometrial hyperplasia with atypia

The value of MRI in management of endometrial hyperplasia with atypia

Trends in incidence of uterine cancer in Songkhla, Southern Thailand

Therapeutic efficacy of gentle endometrial curettage on antibiotic‐resistant chronic endometritis in infertile women

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