The Incidence of Transfusion-Associated Hepatitis G Virus Infection and Its Relation to Liver Disease

Alter, Harvey J.; Nakatsuji, Yoshiyuki; Melpolder, Jacqueline C.; Wages, John; Wesley, Robert; Shih, Jennifer; Kim, J. P.

doi:10.1056/nejm199703133361102

Cited by 567 publications

(392 citation statements)

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“…History of heavy alcohol intake was to several years, 4 and clearance is usually followed by detection of also found in 51 of the 107 patients (47.7%) with HBV, HCV, anti-E2 in serum. 12-14 Therefore, we also investigated the presence or HGV infections.…”

Section: Pothesis Of An Association Between Hgv Infection and Hccmentioning

confidence: 99%

“…25 On the other hand, HGV prevalence among controls partments of Ophthalmology, Dermatology, Urology, Cardiis in agreement with the 1%-2% value reported among healthy ology, and Internal Medicine at the ''Spedali Civili'' and ''S.Orsubjects and blood donors around the world. 1,4,6,[22][23][24] sola'' Hospitals in Brescia for their help in recruiting the The lower HGV RNA prevalence among HCC cases found controls. The cooperation of the ''Center for the Study of in this study than in others is probably attributable to the Surgical Liver Diseases'' of the University of Brescia, funded different study design.…”

Section: Aid Hepa 0035mentioning

confidence: 99%

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A case-control study on GB virus C/hepatitis G virus infection and hepatocellular carcinoma.

et al. 1997

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A new hepatitis-associated RNA virus of the Flaviviridae products, intravenous drug use, hemodialysis, and maybe sexual contacts and from mothers to infants. 4-11 HGV RNA family has been identified and named GB virus C/ hepatitis G virus (HGV). We carried out a case-control study to evaluate has been found in patients with acute or chronic hepatic diseases and in subjects without liver diseases by use of RTthe association of HGV infection with hepatocellular carcinoma (HCC). We recruited 170 patients hospitalized for HCC PCR. 1,2 A test was developed recently to detect the presence of antibodies against HGV envelope 2 protein in human sera, (143 male and 27 female, mean age 64 years) and 306 patients hospitalized for nonliver diseases (controls) in Brescia, Italy. the HGV E2 antigen (anti-E2). 12-14 Anti-E2 has been associated with loss of detectable HGV viremia, and therefore it is HGV RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and antibodies against HGV E2 pro-considered a marker for recovery from infection. Data on its seroprevalence suggest that the number of people infected tein (anti-E2) by an immunoassay test. HGV RNA was found in 8 cases (4.7%) and 4 controls (1.3%). The relative risk by the virus is higher than was estimated on the basis of HGV RNA seroprevalence. (RR) for HGV RNA positivity adjusted for demographic variables and hepatitis B surface antigen (HBsAg), hepatitis CIn spite of the large number of studies carried out on HGV so far, it is still unknown whether the virus can determine virus (HCV) RNA, and alcohol was 7.3 (95% confidence interval, 1.7-30.6; P Å .009). No HGV RNA-positive subject was liver disease in humans. 15 In fact, most information on HGV prevalence comes from case series, in which selection bias also positive for anti-E2. Anti-E2 prevalence did not differ significantly between cases (20%) and controls (15.3%), and cannot be excluded, thus making comparisons difficult. The case-control study design has been suggested to investigate no RR increase was found by this marker. Among subjects with HGV exposure (HGV RNA plus anti-E2 positive), a whether HGV is associated with liver disease. 5 To assess the association of hepatocellular carcinoma (HCC) with HGV greater proportion of cases (40%) than controls (14%) had transfusion history. The possible role of HGV in HCC etiology infection, we carried out a hospital-based case-control study in the province of Brescia, an area in northern Italy with one seems modest because the population-attributable risk is lower (4%) than those for HBsAg (22%), HCV RNA (36%), of the highest incidence rates of HCC in Europe. 16 and heavy alcohol intake (52%). This study supports the hy- PATIENTS AND METHODS pothesis of an association between HGV infection and HCC,This study is part of a large case-control study carried out to although at present there are insufficient data on the causality A new hepatitis-associated RNA virus of the Flaviviridae (HCV) and its genotypes, and alcohol drinking have been reported family...

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Section: Pothesis Of An Association Between Hgv Infection and Hccmentioning

confidence: 99%

Section: Aid Hepa 0035mentioning

confidence: 99%

A case-control study on GB virus C/hepatitis G virus infection and hepatocellular carcinoma.

et al. 1997

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“…Among the 7 patients in our current series with posttransplantation-acquired HCV infec- To date, no consistent relationship between HGV and acute or chronic liver disease has been shown. 5,9 Although HGV was prevalent among transplant recipients (52% were HGV RNA positive after transplantation), it was not associated with the presence of posttransplantation liver disease. This is consistent with other reports of HGV in transplant recipients.…”

Section: Discussionmentioning

confidence: 97%

“…HCV infection was shown in 63 patients (80%), but hepatitis remained unexplained in a proportion. 5 This study examines the presence and severity of posttransplantation liver disease in patients undergoing liver transplantation for chronic liver disease of nonviral cause and investigates the relationship between viruses known to be associated with chronic hepatitis (HBV, HCV) and the clinical course and severity of posttransplantation liver disease.…”

mentioning

confidence: 99%

Hepatitis after liver transplantation: The role of the known and unknown viruses

et al. 1998

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“…18 Reassurance that HGV is not clinically relevant was shown by a low prevalence of HGV RNA in patients with endstage liver disease. 19,20 A novel DNA virus, transfusion transmitted virus (TTV), which has a high incidence in blood donors and patients with chronic liver disease, also appears to have no clear disease association. 21,22 …”

Section: Viruses Not Relevant To Immunoglobulinmentioning

confidence: 99%

Safety and availability of immunoglobulin replacement therapy in relation to potentially transmissable agents

Chapel¹

1999

Clinical and Experimental Immunology

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The Incidence of Transfusion-Associated Hepatitis G Virus Infection and Its Relation to Liver Disease

Abstract: HGV was common in a group of volunteer blood donors, and it can be transmitted by transfusion. Most HGV infections were not associated with hepatitis. HGV did not worsen the course of concurrent HCV infection. No causal relation between HGV and hepatitis has been established.

Cited by 567 publications

References 10 publications

A case-control study on GB virus C/hepatitis G virus infection and hepatocellular carcinoma.

A case-control study on GB virus C/hepatitis G virus infection and hepatocellular carcinoma.

Hepatitis after liver transplantation: The role of the known and unknown viruses

Safety and availability of immunoglobulin replacement therapy in relation to potentially transmissable agents

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