The incidence of spontaneous movements (myoclonus) in dogs undergoing total intravenous anaesthesia with propofol

Cattai, Andrea; Rabozzi, Roberto; Natale, V. Di; Franci, Paolo

doi:10.1111/vaa.12160

Cited by 19 publications

(14 citation statements)

References 11 publications

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“…In this study, neither apnoea, nor other anaesthetic-related adverse effects were observed during induction and in the following minutes, despite these reported to be possible after propofol administration in other studies [ 42 , 43 ]. Observing HR trend at the different time points a second peak at 150 s can be notice.…”

Section: Discussioncontrasting

confidence: 74%

Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring

Cattai¹,

Rabozzi²,

Ferasin³

et al. 2018

BMC Vet Res

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BackgroundPropofol is one of the most widely used injectable anaesthetic agents in veterinary practice. Cardiovascular effects related to propofol use in dogs remain less well defined. The main objective of this study was to evaluate the haemodynamic changes during induction of general anaesthesia with propofol in healthy dogs, by a beat-to-beat continuous monitoring. All dogs were premedicated with intramuscular acepromazine (0.015 mg/kg) and methadone (0.15 mg/kg). Transthoracic echocardiography was used to measure the velocity time integral (VTI) of the left ventricular outflow tract. A syringe driver, programmed to deliver propofol 5 mg/kg over 30 s followed by a continuous infusion of 25 mg/kg/h, was used to induce and maintain anaesthesia. From the initiation of propofol administration, heart rate (HR) and mean invasive arterial blood pressure (MAP) were recorded every 5 s for 300 s, while aortic blood flow was continuously recorded and stored for 300 S. maximum cardiovascular depression was defined the lowest MAP (MAP_Tpeak) recorded during the monitored interval. VTI and VTI*HR were calculated at 0, 30, 90, 120, 150 and 300 s post administration of propofol, and at MAP_Tpeak. Haemodynamic effects of propofol in relation to plasma and biophase concentrations were also evaluated by pharmacokinetics simulation.ResultsThe median (range) HR was significantly higher (p = 0.006) at the moment of maximum hemodynamic depression (Tpeak) [105(70–148) bpm] compared with pre-induction values (T0) [65(50–120) bpm]. The median (range) MAP was significantly lower (p < 0.001) at Tpeak [61(51–69) mmHg] compared with T0 [88(72–97) mmHg]. The median (range) VTI and VTI*HR were similar at the two time points [11.9(8.1–17.3) vs 13,3(9,4-16,5) cm, and 1172(806–1554) vs 1002(630–1159) cm*bpm, respectively].ConclusionsInduction of anaesthesia with propofol causes a drop of arterial pressure in healthy dogs, however cardiac output is well maintained by compensatory chronotropic response. The magnitude of MAP_Tpeak may be strictly related with propofol plasma concentration.

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Section: Discussioncontrasting

confidence: 74%

Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring

Cattai¹,

Rabozzi²,

Ferasin³

et al. 2018

BMC Vet Res

Self Cite

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“…Neuroexcitation is an uncommon side effect associated with propofol use in human beings and can be observed during induction and maintenance of, or emergence from, anaesthesia (Walder and others 2002). Such signs have also been reported in dogs (Cattai and others 2015) but to the authors’ knowledge, this is the first case describing persistent seizure‐like phenomena (SLP) after administration of propofol.…”

Section: Introductionsupporting

confidence: 59%

“…In dogs, the incidence of involuntary movements observed with propofol use has been established at 1.2 per cent (1/82 cases) (Cattai and others 2015), which is far lower than the 7.5 per cent incidence previously reported (Davies and others 1991). This discrepancy may be partly explained by the difficulty in classifying involuntary movements and disorders (Mitek and others 2013).…”

Section: Discussionmentioning

confidence: 65%

“…Midazolam was given with a fentanyl infusion because it is common in the hospital ICU to keep patients sedated with a combination of benzodiazepines and opioids, which facilitates assisted ventilation (if required) without affecting oxygen delivery and global tissue perfusion (Ethier and others 2008). It has been reported that benzodiazepines fail to control SLP in the long term (Hyung Won and others 2007, Mitek and others 2013, Cattai and others 2015), possibly because of the complexity of GABA A R and the action of propofol on glycine receptors (San-juan and others 2010). …”

Section: Discussionmentioning

confidence: 99%

“…Neuromuscular blocking agents have also been used to treat SLP (Cattai and others 2015), although the use of these drugs should be contraindicated if EEG to detect ongoing epileptiform activity is unavailable. In addition, residual neuromuscular block is a possible complication and may result in laryngeal dysfunction, increased risk of aspiration, reduction in upper airway dimensions and function, and increased incidence of postoperative hypoxaemia (Murphy and others 2008).…”

Section: Discussionmentioning

confidence: 99%

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Prolonged seizure‐like phenomena in an English springer spaniel after total intravenous anaesthesia with propofol

Monticelli

Seymour

2015

Vet Record Case Reports

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Propofol is an anaesthetic agent commonly used for both induction and maintenance of general anaesthesia and has been associated with seizure-like phenomena (SLP) in both veterinary and human medicine. This case report describes an English springer spaniel with no previous history of neurological symptoms, which exhibited SLP after propofol anaesthesia for bronchoscopy. The SLP were refractory to treatment for 13 hours, but steadily improved after administration of phenobarbital and levetiracetam. To the authors’ knowledge, this is the first report of their use to manage SLP.

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Induction Drugs

Carter

2024

Pharmacology in Veterinary Anesthesia and Analgesia

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The incidence of spontaneous movements (myoclonus) in dogs undergoing total intravenous anaesthesia with propofol

Cited by 19 publications

References 11 publications

Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring

Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring

Prolonged seizure‐like phenomena in an English springer spaniel after total intravenous anaesthesia with propofol

Induction Drugs

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