The incidence of severe chronic ileitis after abdominal and/or pelvic external irradiation with high energy photon beams

Daly, N; Izar, F.; Bachaud, Jean-Marc; Delannes, M.

doi:10.1016/0167-8140(89)90140-0

Cited by 35 publications

(7 citation statements)

References 20 publications

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“…It is reasonable that the relative field size is important but we could not characterize that relationship, nor was it significant in a prior study 6 . However, the overall impact of treatment volume of the human gastrointestinal tract on development of late complications is controversial 7–13 . In rectal radiation in the rat, when 50% of the circumference of the rectum was irradiated, the frequency of rectal obstruction was less than if the entire circumference was irradiated.…”

Section: Discussionmentioning

confidence: 92%

“…6 However, the overall impact of treatment volume of the human gastrointestinal tract on development of late complications is controversial. [7][8][9][10][11][12][13] In rectal radiation in the rat, when 50% of the circumference of the rectum was irradiated, the frequency of rectal obstruction was less than if the entire circumference was irradiated. In the present study, the circumference and percent portion of the colon and/or rectum irradiated was not obtainable due to lack of 3D computer planning in all of the patients.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of Normal Tissue Complications in 51 Dogs Undergoing Definitive Pelvic Region Irradiation

Arthur

Kleiter

Thrall

et al. 2008

Vet Radiology Ultrasound

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Our objective was to further characterize the late normal tissue complications developing after definitive irradiation of pelvic region tumors in dogs, and to search for prognostic factors. The medical records of dogs receiving definitive irradiation of the pelvic region between 1987 and 2005 were reviewed. The following criteria were established for inclusion: total dose > or =45 Gy, a portion of colon in the primary field, and a minimum of 6 months follow-up. Fifty-one dogs were identified. Prognostic factors evaluated included multiple descriptors of the patient, tumor and radiation treatment. One or more late complications were documented in 20 of 51 patients (39%). Complications were necrotic drainage/ulceration in the skin and subcutaneous tissues within the radiation field (n=7), chronic colitis (n=4), strictures (n=4), osteopenia (n=2), and one each rectal perforation, urinary bladder thickening, iliosacral osteosarcoma, pelvic limb edema, and perianal pain. Two prognostic factors were identified. There was an increase in complications in dogs with perineal tumors compared with other pelvic region sites (P = 0.04), and also in dogs with larger radiation fields (P = 0.04). The finding of an association of tumor site to complications may be a spurious finding and the association between field size and complications is not unexpected although absolute difference in field size between dogs with and without complications was small. There was no association between development of complications and survival. Based on the observed complication rate, consideration can be given to reducing dose per fraction in dogs receiving definitive pelvic region irradiation to <3 Gy.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Characterization of Normal Tissue Complications in 51 Dogs Undergoing Definitive Pelvic Region Irradiation

Arthur

Kleiter

Thrall

et al. 2008

Vet Radiology Ultrasound

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“…Within the combinatorial radiochemotherapy treatment regimen, the administered dose of capecitabine was lower than in other cases, leading the authors to speculate that pelvic irradiation may increase the risk of developing ileitis in patients receiving neoadjuvant capecitabine. In a retrospective review of 188 patients who received abdominal or pelvic radiotherapy, Daly et al found the incidence of chronic ileitis to range from 2.2% to 14.3%, possibly due to radiation enteritis [ 14 ]. In order to mitigate this rare complication, meticulous identification and constrained contouring of organs at risk is especially critical to ensure both safety and efficacy of treatment delivery.…”

Section: Discussionmentioning

confidence: 99%

Capecitabine-Induced Terminal Ileitis: Case Report and Literature Review

Klimko¹,

Tieranu²,

Olteanu³

et al. 2021

Cureus

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Capecitabine is a well-established agent for adjuvant chemotherapy in breast and colorectal cancers. However, one of the limiting adverse events of this therapy is severe diarrhea, which is reported with increasing frequency as of late. Capecitabine-induced ileitis should be suspected in cases with severe, treatment-refractory diarrhea. We present a case of capecitabine-induced terminal ileitis in a patient who received the medication as adjuvant therapy for previously resected colon adenocarcinoma. Capecitabine-induced diarrhea secondary to ileitis is a severe adverse drug event, which occurs during adjuvant chemotherapy and does not respond to conservative treatment with antidiarrheals, often necessitating permanent drug withdrawal. A high index of suspicion is critical as the complications, such as dehydration and the associated electrolyte derangements, may be life-threatening if diagnosis and cause-specific treatment are delayed.

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“…Finally, a growing rate of surgery for CDD was observed in northern China over the past decade. In the context of an aging population, the prevalence of spine surgery will continue to increase owing to the progressive nature of CDD [37,41,54]. A study in the southeast United States reported that the highest annual incidence of cervical disc herniation between 1976 and 1990 was among individuals in their 60s [55].…”

Section: Principal Findingsmentioning

confidence: 99%

Identifying the Characteristics of Patients With Cervical Degenerative Disease for Surgical Treatment From 17-Year Real-World Data: Retrospective Study

Zheng¹,

Wu²,

Wang³

et al. 2020

JMIR Med Inform

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Background Real-world data (RWD) play important roles in evaluating treatment effectiveness in clinical research. In recent decades, with the development of more accurate diagnoses and better treatment options, inpatient surgery for cervical degenerative disease (CDD) has become increasingly more common, yet little is known about the variations in patient demographic characteristics associated with surgical treatment. Objective This study aimed to identify the characteristics of surgical patients with CDD using RWD collected from electronic medical records. Methods This study included 20,288 inpatient surgeries registered from January 1, 2000, to December 31, 2016, among patients aged 18 years or older, and demographic data (eg, age, sex, admission time, surgery type, treatment, discharge diagnosis, and discharge time) were collected at baseline. Regression modeling and time series analysis were conducted to analyze the trend in each variable (total number of inpatient surgeries, mean age at surgery, sex, and average length of stay). A P value <.01 was considered statistically significant. The RWD in this study were collected from the Orthopedic Department at Peking University Third Hospital, and the study was approved by the institutional review board. Results Over the last 17 years, the number of inpatient surgeries increased annually by an average of 11.13%, with some fluctuations. In total, 76.4% (15,496/20,288) of the surgeries were performed in patients with CDD aged 41 to 65 years, and there was no significant change in the mean age at surgery. More male patients were observed, and the proportions of male and female patients who underwent surgery were 64.7% (13,126/20,288) and 35.3% (7162/20,288), respectively. However, interestingly, the proportion of surgeries performed among female patients showed an increasing trend (P<.001), leading to a narrowing sex gap. The average length of stay for surgical treatment decreased from 21 days to 6 days and showed a steady decline from 2012 onward. Conclusions The RWD showed its capability in supporting clinical research. The mean age at surgery for CDD was consistent in the real-world population, the proportion of female patients increased, and the average length of stay decreased over time. These results may be valuable to guide resource allocation for the early prevention and diagnosis, as well as surgical treatment of CDD.

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The incidence of severe chronic ileitis after abdominal and/or pelvic external irradiation with high energy photon beams

Cited by 35 publications

References 20 publications

Characterization of Normal Tissue Complications in 51 Dogs Undergoing Definitive Pelvic Region Irradiation

Characterization of Normal Tissue Complications in 51 Dogs Undergoing Definitive Pelvic Region Irradiation

Capecitabine-Induced Terminal Ileitis: Case Report and Literature Review

Identifying the Characteristics of Patients With Cervical Degenerative Disease for Surgical Treatment From 17-Year Real-World Data: Retrospective Study

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