The Incidence of Retinal Vein Occlusion in Patients with Pseudoexfoliation Glaucoma: A Retrospective Cohort Study

Abstract

Purpose: The aim of this study was to evaluate pseudoexfoliation (PXF) as an independent risk factor for the occurrence of retinal vein occlusion (RVO). Methods: This is a retrospective cohort study on the records of 300 PXF glaucoma patients (PXF group), 300 non-PXF glaucoma patients, and 599 nonglaucoma non-PXF (nGnP group) patients. Results: Multivariate analysis resulted in a significant probability for RVO in the PXF (p = 0.005; OR 2.29 [1.13–4.68]) and non-PXF glaucoma groups (p = 0.005; OR 3.03 [1.55–5.94]) compared to the nGnP group. There was a much higher probability for central RVO (CRVO) in the PXF (p = 0.013; OR 3.64 [1.39–9.49]) and non-PXF glaucoma groups (p = 0.013; OR 3.78 [1.48–9.65]) compared to the nGnP group. After matching and excluding neovascular glaucoma, no significant difference was found between the PXF and non-PXF glaucoma groups regarding RVO (p = 0.541), CRVO (p = 0.092), and branch RVO (p = 0.774). Conclusions: PXF and other types of glaucoma are associated with RVOs, mainly CRVO. PXF was not found to be an independent risk factor for CRVO.

Review: The Development of Risk Factors and Cytokines in Retinal Vein Occlusion

“…Regular review of CSCR patients may be the main approach to prevent the occurrence of RVO. Pseudoexfoliation syndrome (PXF) is the dominating risk factor of glaucoma and has a relationship with RVO but whether PXF is an independent risk factor of RVO requires more evidence ( 127 ). Autoimmune diseases such as psoriasis and systemic lupus erythematosus can also increase the risk of RVO ( 128 , 129 ).…”

Pseudoexfoliationssyndrom und Glaukom

“…Venöse Gefäßverschlüsse scheinen bei PEX-Syndrom gehäuft aufzutreten. Das Risiko, einen retinalen Venenverschluss zu erleiden, ist für Patienten mit PEX-Glaukom im Vergleich mit Kontrollpatienten 2,3-fach erhöht [11]. Ein höheres Risiko im Vergleich zu anderen Glaukomformen konnte nicht beobachtet werden [11].…”

“…Das Risiko, einen retinalen Venenverschluss zu erleiden, ist für Patienten mit PEX-Glaukom im Vergleich mit Kontrollpatienten 2,3-fach erhöht [11]. Ein höheres Risiko im Vergleich zu anderen Glaukomformen konnte nicht beobachtet werden [11]. Bei der Konversion zum PEX-Glaukom zeigt die Papille die klassischen glaukomatösen Veränderungen.…”