The Incidence of Peripheral Nerve Injury in Extremity Trauma

Taylor, Christopher A.; Braza, Diane W.; Rice, J. Bradford; Dillingham, Timothy R.

doi:10.1097/phm.0b013e31815e6370

Cited by 444 publications

(304 citation statements)

References 7 publications

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“…[13] The high incidence of PNI in male patients is reflected in other sources in the literature. [9,10,[13][14][15][16] The exception for this rule can be seen in the study of Taylor et al, [6] which reported almost equal PNI in males and females. Additionally, Ahrari et al [9] reported 52% of male injury in the Bam earthquake, which may be due to almost similar involvement of both sexes in disasters.…”

Section: Length Of Hospital Stay and Expensesmentioning

confidence: 79%

“…[5][6][7] The Injury Severity Score (ISS) was computed by the sum of squares of the highest AIS score in the three body regions with the most injury. Statistical analysis was conducted consisting of Student's t test and non-parametric tests including the Mann-Whitney U test and Kruskal-Wallis test to compare means and chi-square testing, where appropriate.…”

Section: Methodsmentioning

confidence: 99%

“…17 Sayı -No. 6 541 Table 4. DISCUSSION This study showed that the incidence of PNI is 1.3% in trauma patients in trauma hospitals in Iran.…”

Section: Length Of Hospital Stay and Expensesmentioning

confidence: 99%

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The incidence of peripheral nerve injury in trauma patients in Iran

Saadat

Eslami²,

Rahimi‐Movaghar

2011

Ulus Travma Acil Cerrahi Derg

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AMAÇBir-34 yaşındaki hastalarda yaralanma önde gelen mortalite, sakatlık ve sağlık bakım gideri nedenidir. Birinci seviye travma hastalarının %2'si ile %3'ü periferik sinir hasarına (PSH) sahiptir. GEREÇ VE YÖNTEMVeriler Ağustos 1999'dan Şubat 2004'e kadar olan zaman aralığı içinde ICD9-kodlarına göre İran Ulusal Travma Kayıt veritabanından toplandı. Bilgiler demografi, PSH'ye ilişkin mekanizma, seviyeler ve bölgeler ile eşlik eden hasarlar, Kısaltılmış Hasar Skalası, hastanede kalma süresi ve hastane giderlerini içerdi. BULGULAR16,753 hastanın 219'u (%1,3) PSH'li ve 182'si (%83,1) erkek idi. PSH'li hastaların ortalama yaşı, sinir hasarı olmayan hastalarınkine göre daha düşük bulundu (28.6±14.45 ve 33±21,08 yaş; p<0,001). En yaygın PSH nedeni, keskin cisimden kaynaklanan direkt laserasyondu (%61) bunu karayolu trafik kazaları (%22) izledi. Penetran travma, penetran yaralanmalara göre daha yaygındı (%5,6 ve %0,4, p<0,001). En sık PSH, dirsek ile el bölge-sinde görüldü. (%10). Ulnar sinir, en sık olarak yaralanan sinirdi. Ulnar sinir yaralanmasına ilişkin en yaygın alan, ön kol oldu (%15,3). SONUÇKeskin laserasyon ve trafik kazası, genç yaş erkeklerde daha sık olan PSH'ye ilişkin en yüksek oranlara sahiptir. Dirsekten itibaren ele doğru olan açık yaralar, triyajda PSH'ye ilişkin kuşkuyu artırmalıdır. PSH'ye yol açan yaralanmalar nadir olmakla birlikte, bunların sonuçları ve sakatlıkları daha ileri araştırma gerektirmektedir.Anahtar Sözcükler: Ekstremite travması; insidans; periferik sinir yaralanması; karayolu trafik kazaları.

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Section: Length Of Hospital Stay and Expensesmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The incidence of peripheral nerve injury in trauma patients in Iran

Saadat

Eslami²,

Rahimi‐Movaghar

2011

Ulus Travma Acil Cerrahi Derg

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“…6,17,20,25 Most of these studies involve retrospective analyses of single-institution or regional experiences, 6,17,20,25 with limited generalization, given their inherent selection bias. Our national data demonstrate that this number likely underestimates the true incidence of PNIs in fall victims.…”

Section: Discussionmentioning

confidence: 99%

“…19 A similar incidence has been reported for all categories of PNIs in regional experiences, without a focus on fall-injured patients. 6,17,20,25 In children, PNIs are commonly associated with trauma during birth. Several authors 18 have shown the prevalence of birth-related PNIs to be around 0.1%.…”

mentioning

confidence: 99%

Falls and peripheral nerve injuries: an age-dependent relationship

Bekelis

Missios

Spinner

2015

JNS

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obJect Despite the growing epidemic of falls, the true incidence of peripheral nerve injuries (PNIs) in this patient population remains largely unknown. methods The authors performed a retrospective cohort study of 839,210 fall-injured patients who were registered in the National Trauma Data Bank (NTDB) between 2009 and 2011 and fulfilled the inclusion criteria. Regression techniques were used to investigate the association of demographic and socioeconomic factors with the rate of PNIs in this patient population. The association of age with the incidence of PNIs was also investigated. results Overall, 3151 fall-injured patients (mean age 39.1 years, 33.3% females) sustained a PNI (0.4% of all falls). The respective incidence of PNIs was 2.7 per 1000 patients for ground-level falls, 4.9 per 1000 patients for multilevel falls, and 4.5 per 1000 patients for falls involving force. This demonstrated a rapid increase in the first 2 decades of life, with a maximum rate of 1.1% of all falls in the 3rd decade, followed by a slower decline and eventual plateau in the 7th decade. In a multivariable analysis, the association of PNIs with age followed a similar pattern with patients 20-29 years of age, demonstrating the highest association (OR 2.34 [95% CI 2.0-2.74] in comparison with the first decade of life). Falls involving force (OR 1.25 [95% CI 1.14-1.37] in comparison with multilevel falls) were associated with a higher incidence of PNIs. On the contrary, female sex ) and ground-level falls ) were associated with a lower rate of PNIs. coNclusioNs Utilizing a comprehensive national database, the authors demonstrated that PNIs are more common than previously described in fall-injured patients and identified their age distribution. These injuries are associated with young adults and falls of high kinetic energy.

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Human Induced Pluripotent Stem Cell–Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury

Pepper

Wang

Hennes

et al. 2017

JAMA Facial Plast Surg

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IMPORTANCE Human motor neurons may be reliably derived from induced pluripotent stem cells (iPSCs). In vivo transplant studies of human iPSCs and their cellular derivatives are essential to gauging their clinical utility.OBJECTIVE To determine whether human iPSC-derived motor neurons can engraft in an immunodeficient mouse model of sciatic nerve injury. DESIGN, SETTING, AND SUBJECTSThis nonblinded interventional study with negative controls was performed at a biomedical research institute using an immunodeficient, transgenic mouse model. Induced pluripotent stem cell-derived motor neurons were cultured and differentiated. Cells were transplanted into 32 immunodeficient mice with sciatic nerve injury aged 6 to 15 weeks. Tissue analysis was performed at predetermined points after the mice were killed humanely. Animal experiments were performed from February 24, 2015, to May 2, 2016, and data were analyzed from April 7, 2015, to May 27, 2016.INTERVENTIONS Human iPSCs were used to derive motor neurons in vitro before transplant. MAIN OUTCOMES AND MEASURESEvidence of engraftment based on immunohistochemical analysis (primary outcome measure); evidence of neurite outgrowth and neuromuscular junction formation (secondary outcome measure); therapeutic effect based on wet muscle mass preservation and/or electrophysiological evidence of nerve and muscle function (exploratory end point).RESULTS In 13 of the 32 mice undergoing the experiment, human iPSC-derived motor neurons successfully engrafted and extended neurites to target denervated muscle. Human iPSC-derived motor neurons reduced denervation-induced muscular atrophy (mean [SD] muscle mass preservation, 54.2% [4.0%]) compared with negative controls (mean [SD] muscle mass preservation, 33.4% [2.3%]) (P = .04). No electrophysiological evidence of muscle recovery was found.CONCLUSIONS AND RELEVANCE Human iPSC-derived motor neurons may have future use in the treatment of peripheral motor nerve injury, including facial paralysis.LEVEL OF EVIDENCE NA.

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The Incidence of Peripheral Nerve Injury in Extremity Trauma

Abstract: When looking at the population sampled, rates for peripheral nerve injury in people incurring limb trauma are low. Crush injuries seem to have the highest rate of associated nerve injury. Further studies are needed to observe outcomes for people with nerve damage after trauma.

Cited by 444 publications

References 7 publications

The incidence of peripheral nerve injury in trauma patients in Iran

The incidence of peripheral nerve injury in trauma patients in Iran

Falls and peripheral nerve injuries: an age-dependent relationship

Human Induced Pluripotent Stem Cell–Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury

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