The incidence of osteoarthritic change on computed tomography of Korean temporomandibular disorder patients diagnosed by RDC/TMD; a retrospective study

Kim, Kilyong; Wojczyńska, Aleksandra Zumbrunn; Lee, Jeong-Yun

doi:10.3109/00016357.2015.1136678

Cited by 33 publications

(35 citation statements)

References 24 publications

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“…Fourthly, only female subjects were included in this study. Although female predominance of TMJ OA has been well established , the absence of male subjects could limit the understandings of the pathophysiology of TMD in adolescents. Future prospective studies with larger samples, and different cephalometric analysis methods should be conducted to further elucidate relationships among dental and skeletal maturation, occurrence of TMD, particularly TMJ OA, and facial profiles.…”

Section: Discussionmentioning

confidence: 99%

“…OA of the temporomandibular joint (TMJ) might be different epidemiologically from OA of the hip or knee joints, occurrence of which is strongly associated with ageing . Early onset of diseases particularly in the circumpubertal phases, as well as female predominance, has already been described very well in previous epidemiological studies of TMJ OA . Moreover, in certain cases, TMJ OA during adolescence shows different patterns from those of adult TMJ OA.…”

Section: Introductionmentioning

confidence: 99%

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Dental and skeletal maturation in female adolescents with temporomandibular joint osteoarthritis

Kang

Yang

Hyun

et al. 2017

J of Oral Rehabilitation

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Occurrence of temporomandibular disorders (TMDs) and temporomandibular joint (TMJ) osteoarthritis (OA) during adolescence may have interactions with mandibular and dental development. The aim of the present study was to investigate relationships between occurrence of TMD and TMJ OA and extents of dental and skeletal development in juvenile female patients. In total, 95 female adolescents (age range, 11-15 years) were selected. Among them, 15 subjects (control) had no signs of TMD, 39 TMD patients did not have OA (TMDnoOA), 17 TMD patients were at initial stage of TMJ OA (TMJOA), and 27 patients showed progressive stage of TMJ OA (TMJOA). Dental age was estimated by Demirjian's stages used in a previous study with Korean adolescents. Craniofacial parameters and cervical vertebrae maturation (CVM) stages, representing skeletal maturity levels, were measured using lateral cephalograms. The estimated dental age was significantly lower than chronological age in all groups, but CVM differences were not statistically significant. Dental age was the lowest, and differences between the chronological age and estimated dental age were the highest among initial stage of TMJOAs followed by progressive stage of TMJOAs, TMDnoOAs and control and were not associated with CVM stages. Cephalometric parameters revealed significant clockwise rotation of the mandible among the TMJOAs compared with controls and TMDnoOAs and were not associated with CVM stages as well. The juvenile female patients with TMD, particularly TMJ OA, showed retarded dental development, mandibular backward positioning and hyperdivergent facial profiles. The TMJ OA may be associated with retarded dental development but not with skeletal maturations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dental and skeletal maturation in female adolescents with temporomandibular joint osteoarthritis

Kang

Yang

Hyun

et al. 2017

J of Oral Rehabilitation

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“…Severe cases of OA may lead to muscle atrophy and joint deformity with an unclear pathophysiological mechanism [Zhang and Jordan, 2010]. According to the World Health Organization (WHO) OA is mainly seen in elder people and its incidence rate is second only to cardiovascular disease worldwide [Collins et al, 2016;Kim et al, 2016]. Mechanical damage, age, obesity, congenital joint abnormalities, joint deformity, inflammation, and other factors have all been linked to the degeneration of articular cartilage, hyperostosis, and osteocyte abnormality, all of which is able to progress to of OA development [Zhang and Jordan, 2010].…”

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confidence: 99%

Retracted: Cyclin D1 Gene Silencing Promotes IL‐1β‐Induced Apoptosis in Rat Chondrocytes

Zan

Yao

et al. 2017

J of Cellular Biochemistry

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This study investigated the effects of cyclin D1 gene silencing on cell proliferation and apoptosis of interleukin-1b (IL-1b)-induced osteoarthritis (OA) chondrocytes. Chondrocytes from healthy sprague-dawley rats were divided into blank, OA model (chondrocytes underwent IL-1b inducement), OA trial (chondrocytes underwent IL-1b inducement with cyclin D1-shRNA treatment), and negative control (NC; chondrocytes underwent IL-1b inducement and control-shRNA treatment) groups. Cell proliferation was assessed by CCK-8 assay, and cell cycle and apoptosis by flow cytometry. qRT-PCR and Western blotting were performed to detect cyclin D1 and apoptosisrelated factors expression levels. Chondrocyte proliferation increased after 72-96 h after incubation. The OA trial group exhibited reduced cell proliferation at 48, 72, and 96 h after treatment. The OA model, OA trial, and NC groups all contained more cells arrested in G1 phase and had higher apoptosis rates than the blank group. Additionally, the OA trial group contained more cells arrested in G1 phase, with increased apoptosis rates compared to the OA model and NC groups. The OA model group had lowest expression of cyclin D1 whereas the blank group contained the highest among the four groups. qRT-PCR also showed that the OA model, OA trial, and NC groups all had increased expression levels of Bax and reduced expression levels of Bcl-2 and P53 compared to the blank group, whereby by the OA group had the most significant change. The combined evidence in our study shows that cyclin D1 gene silencing suppresses proliferation and induces apoptosis of rat chondrocytes in IL-1b-induced OA.

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“…TMJ OA is epidemiologically different from OA of the hip, hand or knee joints, the development of which is closely related to ageing . Early onset of condition, especially during the pubertal phases has already been described in previous reports . The exact pathophysiology of TMJ OA in adolescents, however, has not been clearly revealed.…”

Section: Introductionmentioning

confidence: 96%

Skeletal maturation and predicted adult height in adolescents with temporomandibular joint osteoarthritis

Hong

Lee

Kang

2019

J of Oral Rehabilitation

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| BACKG ROU N DTemporomandibular disorders (TMDs) encompass a collection of musculoskeletal and neuromuscular conditions which affect the temporomandibular joint (TMJ), the masticatory muscles and associated structures. 1 Osteoarthritis (OA) of the TMJ is the most severe type of manifestation of TMD and featured by deterioration and abrasion of the articular cartilage and concomitant remodelling of the underlying subchondral bone. 2 TMJ OA is epidemiologically different from OA of the hip, hand or knee joints, the development of which is closely related to ageing. 3 Early onset of condition, especially during the pubertal phases has already been described in previous reports. 4,5 The exact pathophysiology of TMJ OA in adolescents, however, has not been clearly revealed.Adolescence is a unique life stage during which an individual undergoes a biopsychological transition from childhood to adulthood, SummaryBackground: The occurrence of osteoarthritis (OA) of the temporomandibular joint (TMJ) in juveniles could be associated with fluctuating levels of oestrogen and growth hormone (GH) during adolescence.Objective: To investigate extent of skeletal maturation and predicted adult height in adolescents with TMJ OA. Method:In total, 155 adolescents (54 males, 101 females; mean age, 14.1 ± 2.0 years) were enrolled. Among them, 19 adolescents (CON) showed no sign of TMD, 50 adolescents exhibited signs of disc displacement but did not have TMJ OA (TMDnoOA), 23 adolescents exhibited the initial stage of TMJ OA (TMJOAini) and 63 adolescents exhibited the severe stage of TMJ OA (TMJOApro). TMJ OA was diagnosed based on the Research Diagnostic Criteria axis I and bone age was estimated using the Greulich-Pyle method. The height, weight and body mass index of participated adolescents were measured and statistically converted to z-scores. The predicted adult height and age of peak height velocity (APHV) were calculated using the BoneXpert® software. Results:In female adolescents, the differences between the chronological and bone ages were significantly higher and the z-score for height was significantly lower in the TMJOApro. Female adolescents with TMJOA exhibited a significantly shorter predicted adult height and earlier APHV than those in the CON and TMDnoOA. Conclusion:The adolescents with TMJ OA exhibited premature skeletal maturations and short predicted adult stature, particularly the female adolescents. K E Y W O R D Sadolescent, female, growth, height, osteoarthritis, temporomandibular joint disorders

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The incidence of osteoarthritic change on computed tomography of Korean temporomandibular disorder patients diagnosed by RDC/TMD; a retrospective study

Cited by 33 publications

References 24 publications

Dental and skeletal maturation in female adolescents with temporomandibular joint osteoarthritis

Dental and skeletal maturation in female adolescents with temporomandibular joint osteoarthritis

Retracted: Cyclin D1 Gene Silencing Promotes IL‐1β‐Induced Apoptosis in Rat Chondrocytes

Skeletal maturation and predicted adult height in adolescents with temporomandibular joint osteoarthritis

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