The incidence of non iatrogenic human anti-mouse antibodies and their possible clinical relevance

Lipp, Rainer W.; Passath, A; Leb, G.

doi:10.1007/bf00180423

Cited by 9 publications

(4 citation statements)

References 2 publications

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“…This is the first published interference screening of samples from animals. There are several studies on the prevalence of interfering antibodies in people using different methods and study populations and with varying results (numbers range from <1% to 80%) . It is important to note that the presence of interfering antibodies in a sample does not automatically lead to interference in an immunoassay used for clinical diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of interfering antibodies in dogs and cats evaluated using a species‐independent assay

Bergman

Larsson

Hansson-Hamlin

et al. 2018

Veterinary Clinical Pathol

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Section: Discussionmentioning

confidence: 99%

Prevalence of interfering antibodies in dogs and cats evaluated using a species‐independent assay

Bergman

Larsson

Hansson-Hamlin

et al. 2018

Veterinary Clinical Pathol

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“…Heterophile antibody production may be stimulated by exposure to a variety of antigens including transfused blood,5 vaccinations,6 exposure to mice7 and rabbits,8 therapeutic use of mouse monoclonal antibodies,9 and even dietary antigens 10. Autoimmune diseases may also give rise to antibodies with heterophile activity, for example, rheumatoid factor 11…”

Section: Discussionmentioning

confidence: 99%

False positive cardiac troponin elevation due to heterophile antibodies: more common than we recognise?

Zaidi

Cowell²

2010

Case Reports

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SummaryA 53-year-old woman was admitted with non-exertional chest pain and elevated cardiac troponin I (cTnI) without dynamic changes of ischaemia on the ECG. She had recently undergone coronary angiography which had shown normal coronary vessels. Repeat angiography on this admission was again unremarkable. Samples of blood were sent for analysis using different troponin assays and demonstrated chronic basal elevation of cTnI while simultaneous assay for troponin T (cTnT) remained normal. Subsequent testing revealed the presence of heterophile antibodies interfering with the troponin I assay leading to a false positive result. BACKGROUND

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“…Daten verschiedener Arbeiten deuten vielmehr darauf hin, dass nur eine Minderheit von derartigen Antikörpern relevante Interferenzen verursacht [28,34]. Daten verschiedener Arbeiten deuten vielmehr darauf hin, dass nur eine Minderheit von derartigen Antikörpern relevante Interferenzen verursacht [28,34].…”

Section: Heterophilic Antibodies Lack Of Communication and The Diagnunclassified

Heterophile Antikörper, fehlende Kommunikation und das diagnostische Dilemma

Dietrich¹,

Stiegler

Gressner

et al. 2001

Med Klin

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In this review for clinicians, we explain formation of heterophilic antibodies, mechanisms of interference and present clinical data about affected markers and "side effects" from the literature. Furthermore we discuss possible alternatives and measures against this phenomenon. We consider broad awareness of this problem among clinicians the most important action to avoid further harm to patients.

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The incidence of non iatrogenic human anti-mouse antibodies and their possible clinical relevance

Cited by 9 publications

References 2 publications

Prevalence of interfering antibodies in dogs and cats evaluated using a species‐independent assay

Prevalence of interfering antibodies in dogs and cats evaluated using a species‐independent assay

False positive cardiac troponin elevation due to heterophile antibodies: more common than we recognise?

Heterophile Antikörper, fehlende Kommunikation und das diagnostische Dilemma

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